Objective To observe the safety and effect of magnetotherapy on rabbits with cerebral hemorrhage. Methods Fifty rabbits was used to establish the model of cerebral hemorrhage by perforating the mid artery of brain. CT and dissection were used to observe the hemorrhage. Forty five rabbits were divided into control group, 0.4T magnetic group and 0.8T magnetic group. Observation of the hemorrhage before magnetotherapy and the hemorrhagic absorption after magnetotherapy was conducted with CT scan. Results All of the 50 rabbits manifested such symptoms as weakness, low tension, and low or absent reflex on the contralateral hind limb of the operation side. Cerebral hemorrhage was proved by CT scan and dissection. There was no difference in hemorrhage between magnetotherapy and control group before magnetotherapy. After magnetotherapy, there was significant difference between the magnetotherapy and the control groups, with regard to the hemorrhagic absorption, but no difference between the 0.4T and 0.8T groups was observed. Conclusion Magnetotherapy could improve the intracranial hemorrhagic absorption in rabbit without resulting in secondary hemorrhage.

Objective To investigate the expression of RECK gene in placentas of patients with preeclampsia and its correlation with MMP-2 activation,and explore the possible roles of RECK gene in the placental trophoblast invasion mechanism.Methods RT-PCR and Western blot were used to detect the expression of RECK mRNA and protein respectively in the placental tissues of normal late pregnant women (normal pregnant group,22 cases) and pre-eclamptic patients(22 mild cases and 20 severe cases).Gelatinase zymography was used to determine MMP-2 activation ratio.Results The expression levels of RECK mRNA and protein from placenta tissues in mild,severe pre-eclamptic group were both significantly higher than those in nomal pregnant group.Moreover,the expression levels of RECK mRNA and protein in severe pre-eclamptic group were obviously increased as compared with those in mild pre-eclamptic group.There was significant difference among the three groups (all P<0.01).MMP-2 activation ratio in mild,severe pre-eclamptic group was significantly lower than that in normal pregnant group.MMP-2 activation ratio in severe pre-eclamptie groups was obviously reduced as compared with mild pre-eclamptic group.There was significant difference among the three groups(all P<0.01).The expression leVels of RECK mRNA and protein were significantly negatively correlated with MMP-2 activation ratio (both P<0.01).Conclusion The abnormal high expression of RECK and inhibition of MMP-2 activation in placentas of pre-eclamptic patients may participate in the process of placental trophoblast shallow invasion.