Objective To investigate the association between thromboxane A2 receptor(TXA2R)gene C795T, T924C,G1686A,rs2271875,rs768963 polymorphisms and aspirin resistance(AR)in Chinese Han population. Methods 168 in-patients with cerebral infarction who had been given aspirin from Zhejiang Provincial Taizhou Central Hospital from October 2009 to May 2013 were enrolled. The platelet aggregation rate was conducted by optical method. The inspections of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C)were conducted by enzymatic colorimetry,whereas blood glucose was tested by hexokinase method. The genotypes of three exons loci C795T,T924C,G1686A and two promoters loci rs2271875,rs768963 polymorphisms in TXA2R gene were detected by the polymerase chain reaction-ligase detection reaction(PCR-LDR)technique. The patients were divided into aspirin sensitive group(AS group,139 cases) and AR group(39 cases)according to the aspirin sensitive degree. The differences between two groups in age, smoking,serum TG,TC,HDL-C,LDL-C,concentration of blood glucose and blood pressure(systolic pressure, diastolic pressure)were compared,and in the mean time,the differences between two groups of TXA2R C795T, T924C,G1686A,rs2271875,rs768963 genotype distribution were also compared. Results AR group had higher incidences of cigarette smoking〔89.7%(35/39)vs. 69.8%(90/129)〕and high blood sugar(mmol/L:8.086±2.785 vs 5.631±1.662,P<0.05 and P<0.01)than those in the AS group. There were no statistical significant differences between the two groups in age,serum TG,TC,HDL-C,LDL-C and blood pressure,gender,cases with carotid artery plaque(all P>0.05). It was shown that there was no correlation between TXA2R gene polymorphism and AR. Conclusion The patients with smoking,high concentration of blood glucose have a higher incidence of AR,no correlation between TXA2R gene polymorphism and AR is found.

This paper reflected Physician-Patient Relationship from the "Jing Liang-affair" and concluded four views:Part of medical professionals also belong to vulnerable groups,medical organizations belong to strong groups;compared to those reasonless patients who have over expectations on medicine,medical professionals belong to vulnerable groups too;The medical system should be the root of the deterioration of Physician-Patient Relationship;The burnout of medical professionals is very serious.

After the Statute on Disposing Medical Accident was put in practice,doctors in China are faced with tremendous stress that never faced before.Doctors begin to evade risks with defensive medicine under the stress.There are two types of defensive medicine,one is positive defensive medicine,which will induce to excessive medical treatment for evading risks,another is negative defensive medicine which will lead to nonfeasance in the presence of intensive patients or dangerous diagnosis and treat procedure.Defensive medicine results in inefficiency of medical service and influences patients' safety.How to lessen doctors' defensive medicine will be an important social problem.

Osteoporosis is characterized by reduced bone mass and impaired micro-architectural structure, leading to an increased susceptibility to fractures. It is a complex, multifactorial disorder resulting from genetic factors, environmental factors and gene-environment interactions. Currently there are three opinions on the main pathogenesis of primary osteoporosis in traditional Chinese medicine: kidney deficiency, spleen deficiency, and spleen-kidney deficiency, in which disagreement remains. In this paper, the authors combine the modern etiology of osteoporosis to explain scientific connotation of the three opinions, aiming to comprehend the pathogenesis of primary osteoporosis and strengthen the communication between traditional Chinese medicine and Western medicine, and trying to evaluate the clinical curative effect on osteoporosis.

Through analyzing medical personnel's duty under Bio-psycho-social Medical Mode, this paper states that medical personnel's duty should be emphasized not only on preventing and curing diseases, but also on solving patients' psychological problems.Therefore it states that death education, first, to medical professionals themselves,second,to the patients and their family,is very important,at last it also inquires into the mode of death education.

Limited Price Charge for Single Disease means that hospitals limit price for the patient who has only single disease in the diagnosis and treats process. The charge includes the process from the time when he had been diagnosed and been in hospital to the time when he had been charmed off. Limited Price Charge for Single Disease could solve many ethical problems which exist in current medicine realm, so it means too much in Medical Ethics, and it gives Hospital Administration and Health Care Administration new inspiration.

As a new service model,clinical pathway has been applied in many areas.But there is no study on it from prospective of medical ethics.The author holds that the clinical pathway can enhance help achieving the objective of serving people's health,implementing the principle of informed consent,embody the human-center thinking,and eventually realize the goal of justice.

Objective To investigate the syndrome elements of stable angina pectoris(SAP) to provide objective evidence for syndrome differentiation and treatment.Methods A prospective observation was done on 251 SAP patients confirmed by coronary angiography.The characteristics of TCM symptoms and syndrome distribution were summarized with factor analysis to abstract the syndrome element.Results There were 6 common factors(syndrome element) picked up by the factor analysis.The distribution of syndrome element among the 251 patients were as follows: blood stasis occupying 37.8%,qi deficiency occupying 33.1%,phlegm occupying 16.7%,and yin deficiency occupying 12.4%.Conclusion The major syndrome elements of SAP were blood stasis and qi deficiency.The secondary ones were phlegm and yin deficiency.The location of disease was in heart,mainly with kidney and spleen involved.

Objective To investigate the value of dual-source CT perfusion imaging in evaluation of liver fibrosis stage.Methods Liver fibrosis models were established with 35 rabbits (experimental group)which were intraperitoneally injected with carbon tetra-chloride.Meanwhile,other 5 rabbits were regarded as control group which were intraperitoneally inj eced with physiological saline.7 rabbits of experimental group and 1 of control group were undergone dual-source CT perfusion scan at 4,6,8,10,12 weeks respec-tively.Arterial liver perfusion (ALP),portal venous perfusion (PVP),total hepatic perfusion (THP),hepatic perfusion index (HPI)were recorded,and staging of liver fibrosis were assessed by pathological method.Results With the increase of liver fibrosis degree,HPI showed an upward trend,whereas PVP was opposite.HPIs of S2,S3 and S4 stage were significantly different com-pared to that of control group respectively.The differences of HPI between S3,S4 stage to S0 and S1 stage were significant.PVP between S2,S3,S4 stage to S0 stage and S1 stage were also significant different.Conclusion HPI and PVP can reflect the perfu-sion changes of liver fibrosis stages.Combination of HPI and PVP may help the diagnosis of S2,S3 or S4 stage of liver fibrosis.