Purpose To investigate the clinical effect of a combined treatment on anxiety neurosis. Method Eighty cases of anxiety neurosis were treated by acupuncture-moxibustion plus systematic desensitization.The result was compared with simple acupuncture-moxibustion or simple systematic desensitization. Results and conclusion The cure rate was 52.5% in acupuncturemoxibustion plus systematic desensitization, which was significantly different from that in simple acupuncturemoxibustion or in simple systematic desensitization ( P <0. 05).