Objective To investigate the clinical features of neonatal lower respiratory tract infection (LRTI)with respiratory syncytial virus(RSV),and to explore the relationship between clinical features and recurrcnt cough or wheezing after discharge.Methods From May 2008 to May 2013,the data of 41 neonates diagnosed as LRTI with RSV infection in New Century International Children's Hospital were analyzed retrospectively.The clinical features and follow-up results were observed.Results All the neonates had cough,92.7％ (38/41 cases) had choking,85.4％ (35/41 cases) had runny nose and nasal obstruction,31.7％ (13/41 cases) had fever,65.9％ (27/41 cases) had wheezing sound during physical examination,29.3％ (12/41 cases)of the neonates were accompanied with bacterial infection(n=29),in which 50.0％ (6/12 cases) were infected by staphylococcus aureus.Compared to the neonates only with RSV infection,the proportion of fever was higher in those with RSV combined with bacterial infection (n =12)(x2 =6.034,P ＜ 0.05),and there were no statistical differences between the neonates with or without bacterial infection in white blood cell count and with or without shadow in chest X-ray(x2 =0.859,2.064,P =0.485,0.202).Compared with the neonates without family history of atopy,the neonates with the family history of atopy were more likely to get wheezing (88.2％ vs 57.1％,x2 =4.871,P ＜ 0.05) during primary infection.During the follow-up,there was higher proportion of children with family history of atopy in the group with subsequent recurrent cough and/or wheezing than in the group without subsequent recurrent cough and/or wheezing (71.4％ vs 26.3％,x2 =6.388,P ＜ 0.05).Conclusions Cough,choking are most common symptoms in neonatal LRTI with RSV,and there is no wheezing sound during phy-sical examination in some neonates.LRTI with RSV is likely combined with bacterial infection.Wheezing is more common in the neonates with family history of atopy.The RSV LTRI neonates with family history of atopy incline to get subsequent recurrent cough or wheeze after discharge.

Objective:To explore influence of health education on quality of life and compliance in community pa‐tients with coronary heart disease (CHD) .Methods :A total of 83 community CHD patients were selected and ran‐domly divided into routine treatment group (n=38 ,received routine treatment of CHD ) and health education group (n=45 ,received CHD health education based on routine treatment ) .Score of Seattle angina questionnaire (SAQ) after intervention ,therapeutic compliance and incidence rate of major adverse cardiovascular events (MACE) with‐in six months were compared between two groups .Results:Compared with routine treatment group after interven‐tion ,there were significant rise in each item score and total score of SAQ [total score ,(54.3 ± 7.2) scores vs .(65.4 ± 7.5) scores] ,P<0.05 all;and therapeutic compliance also significantly rose (good rate ,52.6% vs .77.8% ) in health education group , P< 0.05. After six‐month follow‐up ,total incidence rate of MACE in health education group was significantly lower than that of routine treatment group (8.9% vs .26.3% ) , P< 0.05. Conclusion:Health education can significantly improve quality of life ,compliance and prognosis in community patients with cor‐onary heart disease ,which is worth clinical extending and use .

Objective To analyze the malnutrition status among children and adolescents of Wa ethnicity in Lincang prefecture,Yunnan province from 2005 to 2014,and to provide evidence for the improvement of the situation.Methods From 2005 to 2014,children and adolescents aged 7 to 18,from 19 primary and secondary schools in Cangyuan county of Lincang prefecture,Yunnan province,were chosen,using the multistage-stratified-random cluster sampling method,to receive physic examination.WHO-2006 standard was used.Situation related to the rate of growth retardation and malnutrition among students was analyzed,from 2005 to 2014.Data was from the National Student Physical Health Research Project.From 2000 to 2014,trends on nutrition development among these students were also studied.Results The rates related to growth retardation among 7-18 years-old Wa boys in 2005,2010 and 2014 were 45.61％,52.36％ and 35.85％,with the rates of thinness as 1.44％,0.76％ and 1.36％,respectively.Rates on malnutrition were 52.35％,56.01％ and 41.13％,respectively.Rates related to growth retardation among 7-18 years-old Wa girls were 42.03％,47.41％ and 33.06％,respectively,with rates of thinness as 0.91％,0.68％ and 0.83％,respectively.The rates on malnutrition were 46.13％,49.77％ and 35.56％,respectively.From year 2005 to 2014,spurt on height growth of boys and girls were among the 13-14 years-old and 9-10 years-old,respectively.Girls were 4 years earlier,entering the sudden increase in the peak age than boys.Sex difference on height among the 18 years-old Wa youngsters were 11.99,9.34 and 11.38 cm in 2005,2010 and 2014,respectively.Conclusion Malnutrition status of retardation on growth among Wa children and adolescents remained quite serious.

AIM: To study the characterization of thyrotropin receptor (TSHR) and its active fragment TSHR aa352-366 as immunogens in BALB/c mice. METHODS: BALB/c mice were injected peritoneally with TSHR aa352-366-KLH (hemocyanin from keyhole limpets) and the mixture of TSHR aa352-366-KLH and guinea pig TSHR every 15 days, respectively. The levels of thyroid hormones and TSHR antibodies and TSHR mRNA were measured, and the pathological changes of thyroid tissue were observed. RESULTS: In the group injected with TSHR aa352-366-KLH, the serum levels of TT_3 and TT_4 decreased (P