Objective To observe the clinical effect of locking compression plate(LCP)to treat proximal humeral fractures.Methods From October.2006 to May.2008,22 proximal humeral fractures were treated with LCP (WEGO Co.Ltd,SANDONG).Results All of 22 patients were followed up for 8-22 monthes postoperatively.All fractures healed within the period of follow up without looseness of internal fixators.The average healing time was 12.6 weeks.According to Neer' s score,12 cases were excellent,8 cases were good,the other two were fair.The excellent and good rate put together was 90.9%.Conclusion Locking compression plate fixation is a simple and reliable procedure to treat proximal humeral fractures with satisfactory effects.

OBJECTIVE:To observe the clinical efficacy of pegylated interferon α-2a(Peg-INFα-2a)combined with adefovir (ADV)in the treatment of HBeAg-positive chronic hepatitis B (CHB). METHODS:An open randomized controlled clinical trial was performed. According to random number table,70 patients with HBeAg-positive chronic hepatitis B were divided into observa-tion group and control group,with 35 cases in each group. Observation group received Peg-INF α-2a combined with ADV,and control group was treated with Peg-INF α-2a only. Therapeutic efficacy and safety evaluation were evaluated after 24 and 48 weeks of treatment. RESULTS:After 24 weeks of treatment,ALT normalization rate of observation group and control group were 51.43%and 25.71%,and HBV-DNA negative rate of 2 groups were 68.57% and 37.14% respectively,with statistical significance (P<0.05). There was no statistical significance between HBsAg negative rate and HBeAg negative rate (P>0.05). After 48 weeks of treatment,ALT normalization rate of observation group and control group were 77.14% and 54.29%,and HBeAg negative rate 54.29% and 31.43%,and HBV-DNA negative rate 82.86% and 42.86% respectively,with statistical significance(P<0.05).There was no statistical significance in HBsAg negative rate and ADR (P>0.05). CONCLUSIONS:Peg-INFα-2a combined with ADV have good clinical efficacy in the treatment of HBeAg-positive CHB,and it is better than Peg-INFα-2a monotherapy and has less ADR.

Posttraumatic stress disorder (PTSD) is a psychiatric condition that can occur in anyone who has experienced a life-threatening or violent event.Research into the underlying neurobiology has implicated dysregulation in multiple neurotransmitter systems including norepinephrine,serotonin and glutamate as well as the hypothalamic-pituitary axis.Although there was a tremendous growth in the understanding of PTSD in the past few years,the specific neurobiological underpinnings of PTSD wait for more explorations.

Down-regulation of adult hippocampal neurogenesis has been regarded as one of the important biological and cellular basis of depression. Recent studies have shown that there is a close correlation between neurogenesis and angiogenesis. Several angiogenesis factors, especially vascular endothelial growth factor (VEGF), play a vital role on angiogenesis. They not only have the neurotrophic and neuroprotective effects, but also up-regulate hippocampal neurogenesis. Thus,VEGF may be involved in the occurrence and treatment of major depression. This article reviews current understanding of the relationship between adult brain angiogenesis and depression.

Objective To study the effects of the monomers of ginsenoside Rb1 (GSRb1) on the concentrations of intracellular calcium in ischemic neurons of rats.Methods Hippocampus neurons from embryo of rats were cultured in vitro, then placed into normal extracellular fluid (normal control group), simulated ischemic extracellular fluid (ischemia group), simulated ischemic extracellular fluid without calcium (ischemia without calcium group) and simulated ischemic extracellular fluid with different concentration of GSRb1. The fluorescence intensity of intracellular calcium in each group was measured by laser scanning confocal microscope technique, and the corresponding percentage was calculated by comparison with normal control.Results Compared with normal control group, fluorescence intensity of intracellular calcium increased by ( 73.5?10.31)% in ischemia group, ( 4.5?2.58)% in ischemia without calcium group,( 20.2?3.41)%, ( 13.6?2.98)%,( 10.5?3.62)% and ( 12.7?4.51)%, respectively, in simulated ischemic extracellular fluid with different concentration of GSRb1 groups (20, 40, 60 and 80 ?mol/L). The decreases of fluorescence intensity of intracellular calcium in simulated ischemic extracellular fluid with different concentration of GSRb1 groups were significantly different compared with ischemia group (all P

Objective To investigate the properties of hind foot motion and it's changes in ankle or subtalar joint arthrodesis. Methods Eight fresh frozen adult leg-foot specimens were mounted in a coordinated system, a Steinmann pin was perforated across the calcaneus as a marker. The displacements of the marked points in the coordinated system were recorded when subtalar or ankle joint was fixed respectively. Through matrix translation and Euler equation, the angle of the calcaneus rotation were calculated, representing the motion of the subtalar and ankle joints in different condition, Statistical analysis were also taken between different conditions. Results Three dimensional (3-D) motion was observed in hind foot motion. The range of motion with ankle joint fixation was: inversion 15.99??2.81?, eversion 8.62??1.90?, dorsiflexion 3.70??1.00?, plantar flexion 5.87??1.39?, adduction 7.64??2.04?, and abduction 3.99??1.78?. When subtalar joint was fixed, they were: 7.13??1.07?, 5.52??0.85?, 17.09??2.87?, 30.75??5.04?, 10.77??1.56?, and 6.54??1.88? respectively. While they were 22.62??3.21?, 40.88??5.77?, 18.87??3.89?, 9.12??2.05?, 17.48??2.26? and 11.47??2.29?, when no joint was fixed. Arthrodeses of ankle or subtalar joint would affect the hindfoot motion significantly (P

Objective Establish a method for qualitative and quantitative analysis of paraquat dichloride in organs in rat by UPLC-MS/MS and study the rat animal model poisoned by intragastric administration of paraquat dichloride to investigate the postmortem distribution of paraquat dichloride in poisoning death rat. Methods The rats were given an intragastric administration of 1/2LD50 Paraquat dichloride. The rats were dissected at 0.5h, 2h, 4h, 8h, 12h, 24h, 48h, 72h respectively after the intragastric administration. The specimens of -the heart, liver, spleen, lung, kidney, brain, muscle, bladder and stomach-were collected and analyzed immediately. Qualitative and quantitative analysis were performed by UPLC-MS/MS. Results Within 4h, stomach is the main distribution organ. The content of paraquat dichloride is the highest in stomache and relatively low in other organs. The concentration of organization except stomach changed little within 4h. The concentration of stomach has a sharp decline after 4h. The concentration in organs except stomach has a sharp rise after 4h. There is a significant difference(P<0.05) between each organs and brain. Conclusion There was a postmortem maldistribution of paraquat dichloride in poisoning death rats and the concentration in organs changes with time. The analysis method of UPLC-MS/MS and postmortem distribution of paraquat dichloride can be applied to the forensic identification of paraquat dichloride poisoning death and provide direction for delete this part toxicology analysis.

Integrated traditional Chinese and Western medicine therapy for pancreatitis has been used since the 1960s.According to the clinical manifestations and traditional Chinese medicine (TCM) syndrome differentiation of pancreatitis,pancreatitis was named true heart pain with cold limbs caused by spleen disease.Syndrome differentiation of acute pancreatitis and treatment with modified Dachaihu decoction achieved good clinical effects.After the 1990s,the research focus of pancreatitis research was shifted to severe acute pancreatitis (SAP).The clinical course of SAP was divided into three phases,and different therapeutic regimens were given.Clinical studies achieved good therapeutic effects in terms of cure rate and fatality rate.After 2000,integrated traditional Chinese and Western medicine therapy for chronic pancreatitis has been promoted systemically,and the cooperation between traditional Chinese medicine,endoscopic techniques,and operative treatment helps to significantly improve pain control,nutritional status,and incidence of complications.

Objective To study the clinical value of vaccum sealing drainage in plasma cell mastitis.Methods 59 patients with plasma cell mastitis admitted in our hospital were treated with vaccum sealing drainage (the experimental group) from Jan.2011 to Apr.2014.59 plasma cell mastitis patients were treated with traditional vaseline gauze drainage (the control group).Clinical data like hospitalization length,healing time,healing grade,scar size,dressing change frequency,one year recurrence rate and breast deformity were retrospectively analyzed.Results Patients treated with vaccum sealing drainage had shorter hospitalization length and healing time,lower one year recurrence rate and less breast deformity compared to patients treated with traditional Vaseline gauze drainage (P＜0.01),while there was no significant difference in terms of healing grade (P＞0.05).Conclusions Vaccum sealing drainage can significantly shorten the hospitalization time and incision healing time,reduce dressing change frequency and one year recurrence rate in patients with plasma cell mastitis.Because of the smaller scar caused by vaccum sealing drainage,the breast deformity is also less.It is of clinical value for plasma cell mastitis.

Proximal humerus fractures are clinically common upper limb injury,accounting for about 4％ to 5％ of all human fractures.At present,displaced proximal humerus fractures are often treated by locking plate fixation,but complications may follow.Of them,a locking screw piercing the humeral head has the highest incidence and is thus the most common reason for surgery.Such a screw tends to cause claws of the glenoid cavity,leading to severe pain.Therefore,it is an unavoidable challenge how to effectively prevent postoperative screw piercing for orthopedic surgeons who use locking plating to treat proximal humerus fractures.In this paper,the progress in research will be reviewed on the causes and management of screw perforation after locking plate fixation of proximal humerus fracture.