1.A PreIiminary Study of the CIinicaI Significance of Word Recognition Scores in EvaIuating the Curative Effects of Sudden Hearing Loss
Siyu LIANG ; Yun ZHENG ; Gang LI
Journal of Audiology and Speech Pathology 2015;(1):32-33,34
Objective To preliminarily explore the clinical significance of word recognition scores in evalua_ting the curative effects of sudden hearing loss .Methods Pure tone averages (PTA) and word recognition scores (WRS) in 11 cases of sudden hearing loss were obtained on the pre-treatment day and the post -treatment day , and the results were compared .ResuIts The average PTA of 11 cases was 62 .27 ± 15 .36 dB HL on the pre-treat_ment day ,and 60 .23 ± 14 .32 dB HL on the post -treatment day .The average WRS in 11 cases was 42 .91% ± 30 .83% on the pre-treatment day ,and 72 .73% ± 26 .72% on the post-treatment day .There were no significant differences in PTA and the intensity of the sound for testing WRS before and after treatment(P> 0 .05) ,and the difference of the WRS between the pre -treatment and the post -treatment day was statistically significant(P<0 .05) .ConcIusion The WRS could be used in evaluating the curative effect of sudden hearing loss ,which is a sup_plement for PTA .
2.Early diagnosis and intervention in 0-9 months old infants with hearing loss.
Yuan ZHANG ; Gang LI ; Yun ZHENG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(22):1748-1751
OBJECTIVE:
To investigate the current situation of early diagnosis and intervention in 0-9 months old infants with hearing loss and analysis factors that will affect early diagnosis and intervention.
METHOD:
One hundred and eighty-six infants referred to the West China hospital from February 2014 to September 2014 were included. All 186 children were referred due to the fact that either they failed infant hearing screening or outer ear malformation. Early diagnosis and/or intervention were performed on those 186 children and their records of early diagnosis and intervention were analyzed.
RESULT:
Among the 186 infants, 167 (89.8%) were diagnosed with an average age at (4.0 ± 1.4) months. Among the 167 infants with final diagnosis, there were 31 (18.6%) infants diagnosed as conductive hearing loss (CHL), and 99 cases (59.3%) diagnosed as sensorineural hearing loss (SNHL), among whom, there were 75 (44.9%) bilateral SNHL and 24 (14.4%) unilateral SNHL. There were 2 cases (1.20%) with SNHL on one side and atresia on the other side. 5 (2.99%) of all conductive hearing loss cases with unilateral atresia and 2 cases with auditory neuropathy (AN) were found. 33 infants (19.8%) were found to have normal hearing. 30.7% (23/75) infants diagnosed as bilateral SNHL and 8.3% (2/24) infants diagnosed as unilateral SNHL were fitted with hearing aids. The fitting rate in infants with bilateral SNHL with mild, moderate, severe to profound degrees were 0 (0/23), 24.0% (6/25), 66.7% (6/9), 61.1% (11/18) respectively. The average intervention age was (5.0 ± 2.1) months.
CONCLUSION
Although the early diagnosis and intervention situation in this study are very close to international standard, there are still infants without final diagnosis and infants with hearing loss without hearing aid fitting. Further studies and efforts to promote early diagnosis and intervention in infants with hearing loss are needed.
China
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Deafness
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Early Diagnosis
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Hearing Aids
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Hearing Loss, Bilateral
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Hearing Loss, Central
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Hearing Loss, Conductive
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diagnosis
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Hearing Loss, Sensorineural
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diagnosis
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Hearing Tests
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Humans
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Infant
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Infant, Newborn
3.A case of congenital leukemia.
Xiu-li YUAN ; Chang-gang LI ; Yun-sheng CHEN
Chinese Journal of Pediatrics 2005;43(7):498-498
Fatal Outcome
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Humans
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Infant, Newborn
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Leukemia
;
blood
;
congenital
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diagnosis
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Leukocyte Count
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Male
4.Optimization on Extraction Technology of Shu-Feng Ding-Chuan Granules in Huang-Qin Group by Box-Behnken Response Surface Methodology
Ruihua LI ; Ying LI ; Yongxiang WANG ; Yun WU ; Gang DING
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(11):2290-2295
This study was aimed to optimize the extraction technology of Shu-Feng Ding-Chuan(SFDC) granules in the Huang-Qin(HQ)group by Box-Behnken response surface methodology(RSM).With three major characteristic components (baicalin,praeruptorin A and solid content in extraction liquid),the effects of four factors,such as the concentration of ethanol,the dosage of ethanol,the duration of extraction and the extraction times,were investigated by the single factor experiment.Then,the range of parameters of key factors was further studied and explored by Box-Behnken RSM.The results of single factor experiment and Box-Behnken design showed that the optimum preparation conditionswere 8-fold 70% ethanol,extracted for 2 times,with 1.0 h per each time.Under these conditions,the transfer rates of baicalin and praeruptor in A were 89.57% and 87.90%,respectively.And the transfer rateof solid content was 32.35%.It was concluded that the single factor experiment combined with RSM can be used in theoptimization of extraction technology for SFDC granules in the HQ group.This technique wasstable and feasible,which provided scientific evidences for the industrial production.
5.Inflammatory myofibroblastic tumors in dura mater of brain: one case report.
Hong ZENG ; Hai-gang LI ; Yun-jie ZENG
Chinese Journal of Pathology 2006;35(4):254-255
Actins
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metabolism
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Adult
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Brain Neoplasms
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metabolism
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pathology
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surgery
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Desmin
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metabolism
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Diagnosis, Differential
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Dura Mater
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chemistry
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pathology
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Female
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Granuloma, Plasma Cell
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metabolism
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pathology
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surgery
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Humans
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Immunohistochemistry
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Meningeal Neoplasms
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pathology
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Meningioma
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pathology
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Neoplasms, Muscle Tissue
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metabolism
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pathology
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surgery
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Vimentin
;
metabolism
6.Expression and meaning of three neuropeptides in the initial stage of recurring nasal polyp.
Xiu-guo LI ; Guang-gang SHI ; Xiu-yun WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2006;41(4):303-304
Adolescent
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Child
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Female
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Humans
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Male
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Nasal Mucosa
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metabolism
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Nasal Polyps
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metabolism
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Neuropeptides
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classification
;
metabolism
7.Application of single-dose dexmedetomidine infusion in patients undergoing percutaneous dilatational tra-cheostomy
Rongxiang SU ; Yun SHAO ; Gang LI ; Xiaoping GU
Journal of Practical Stomatology 2015;(1):88-91
Objective:To observe the clinical effects of dexmedetomidine(DDM)under monitored anesthesia care(MAC)in oral and maxillofacial patients undergoing percutaneous dilatational tracheostomy(PDT).Methods:38 patients with oral and maxillofa-cial tumor undergoing PDT before surgery were randomly assigned into 2 groups(n =19).Patients in group D received a single-dose DDMof 0.5 μg/kg infused for 10 min;those in group Mreceived 2 mg of midazolam and 1 μg/kg of fentanil.Then all patients were given local anesthesia followed by PDT.MAP,HR and SpO2 were monitored before (T0 )and after drug administration (T1 ),at T2 (skin incision)and T3 (insert dilation catheter).Ramsay scorce,bucking,respiration depression and adverse cardiovascular reaction were recorded.All patients were followed up 24 h postoperatively for the observation of adverse recall of PDT.Results:Compared with T0 ,at T1 ,T2 MAP and HR in group D were lower,but MAP and HR at T3 in group Mwere higher(P <0.05).At T1 ,T2 and T3 ,MAP and HR in group D were significantly lower than those in group M(P <0.05).During operation,the incidence of bucking and respiration depression in group D was lower than that in group M(P <0.05).Conclusion:During PDT operation under MAC,a single-dose dexmedetomidine is effective in stablizing hemodynamics,reducing bucking and respiration depression.
8.L-carnitine inhibits eryptosis induced by uremic serum
Yun SUN ; Gang LIU ; Xuegang LI ; Yimin SHI ; Guangju GUAN
Chinese Journal of Pathophysiology 2015;(7):1324-1328
[ ABSTRACT] AIM: To investigate whether L-carnitine ( LC) inhibits the eryptosis effect of uremic serum on erythrocytes.METHODS:Erythrocyte suspension (2%) was cultured and divided into 3 groups in vitro: control group ( C group) , uremic serum group ( U group, 30%uremic serum) , and uremic serum+LC group ( L group, 30%uremic serum+200 μmol/L LC) .Erythrocytes were collected at 24 h and 48 h.Eryptosis ( phosphatidylserine expression repre-sents eryptosis) was estimated by flow cytometry with Annexin V staining.The content of reactive oxygen species ( ROS) was also detected.Glutathione ( GSH) was measured by ELISA.RESULTS:Eryptosis in C group was increased as the in-cubating time extended.Eryptosis in U group was higher than that in C group, while that in L group was lower than that in U group.Meanwhile, ROS content was higher and GSH was lower in U group than those in C group.ROS content was low-er and GSH was higher in L group than those in C group.CONCLUSION:LC inhibits uremic serum-induced eryptosis by decreasing ROS and increasing GSH, thus attenuating oxidative stress.
9.Inhibitory effect of recombinant LIGHT-Fc gene on the proliferation of human esophageal squamous carcinoma cell line Eca109
Gang XIONG ; Wei WU ; Jun LI ; Kang YANG ; Yun BAI
Chinese Journal of Digestive Surgery 2008;7(4):307-309
Objective To investigate the inhibitory effect of recombinant LIGHT-Fe gene on the proliferation of human esophageal carcinoma cell line Eea109. Methods LIGHT-Fc expression vector was transfected into human esophageal squamous carcinoma cell line Eca109 by using DOTAP liposomal transfection reagents. The effects of LIGHT-Fc gene on the proliferation of esophageal carcinoma cell line Eca109 in vitro were detected by cell growth curve and MTr assay. Forty-five nude mice were equally divided into Eea109/Wt group, Eca109/neo group and Eca109/LIGHT group. Carcinogenesis and pathological expression of the esophageal carcinoma tissues were observed. Results The expressions of LIGHT receptors were detected in Eca109 cells. The proliferation of Eca109 cells was inhibited after trasfecting LIGHT-Fc gene into Eca109 cells. The numbers of tumors generated in Eea109/Wt group, Eca109/neo group and Eca109/LIGHT group were 12, 11 and 5, with statistical significance between Eca109/LIGHT group and the other two groups (X2 =6.652, 4.821, P <0.05). The result of histopatholagical examination indicated that the tissue necrosis appeared significantly in tumors derived from Eea109/LIGHT cells. Conclusions The growth of esophageal squamous carcinoma cell line Eca109 can be suppressed by LIGHT-Fc gene whether in vitro or in vivo.
10.Efficacy and safety of tranexamic acid for treating perioperative bleeding during PFNA internal fixation in elderly femoral intertrochanteric fracture
Yun ZHU ; Gang ZHAO ; Sining LI ; Xiaobing HE
Chongqing Medicine 2017;46(20):2797-2799
Objective To evaluate the effect of preoperative intravenous drip of tranexamic acid(TXA) on perioperative bleeding in proximal femoral nail anti-rotation(PFNA) operation of elderly intertrochanteric fracture.Methods A total of 115 elderly patient with intertrochanteric fracture undergoing PFNA internal fixation were selected and divided into the treatment group(58 cases) and control group (57 cases).The treatment group was intravenously dripped with 20mg/kg TXA before operation,while the control group had no special treatment.Hemoglobin (Hb) and hematocrit(Hct) were recorded before operation and on postoperative 1,3 d.The total amounts of perioperative blood loss were calculated by using the Gross equation and Nadler equation.The blood transfusion rate and thromboembolic complications occurrence situation in the two groups were performed the statistics.Results The total amounts of perioperative blood loss were (872.21±312.53) mL in the treatment group and (1 162.41±368.64) mL in the control group,the difference was statistically significant(P<0.01).The blood transfusion rate was 3.45% in the treatment group and 17.5% in the control group,the difference was statistically significant (P<0.01).No deep vein thrombosis and pulmonary embolism occurred in both groups.The occurrence rate of venous thrombus was 5.1% in the treatment group and 7.0% in the control group without statistical difference(P>0.05).Conclusion Preoperatively intravenous drip of 20mg/kg TXA in PFNA internal fixation of elderly intertrochanteric fracture can effectively decrease perioperative blood loss without increasing the risk of thrombus formation.