Atherosclerosis ; Humans

Objective To analyze the effect of Fuke Xiaoyan prescription combined with nifuratel and nysfungin in senile mycotic vaginitis. Methods 100 patients with senile mycotic vaginitis were randomly divided into the observation group and the control group ,50 cases in each group.The control group were treated with nifuratil nystatin alone.The observation group were treated with Fuke Xiaoyan prescription.The inflammatory factors of tumor necrosis factor (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) and oxidative stress products of SOD, nitric oxide (NO), malondialdehyde (MDA) and endothelin-1 (ET-1) were determined before and after treatment in the two groups.Results The effective rates of the treatment group and the control group were 96.0% and 80.0% respectively.The clinical efficacy of the observation group was higher than that of the control group ( P<0.05 ) .The difference of the inflammatory factors between the two groups was statistically significant ( P<0.05 ) .The levels of SOD and NO in the two groups were significantly higher than those in the control group (P<0.05), but the levels of the inflammatory factors in the observation group were significantly lower than those in the control group ( P<0.05 ) .The levels of MDA and ET-1 in observation group were significantly lower than those in control group (P<0.05).Conclusion Fuke Xiaoyan prescription combined with nifuratil and nystatin has a good effect in the treatment of senile mycotic vaginitis.It can effectively relieve the inflammatory reaction and reduce the level of oxidative stress products , thus improving the patients'life quality.

OBJECTIVE: To establish a controllable management system for clinical pharmacy so as to ensure its quality.METHODS: The clinical pharmacy work was programmed by applying classical PDCA management.RESULTS: By using PDCA cycle,the working system and standards for clinical pharmacists were able to be set up and the performance of clinical pharmacists could be evaluated so as to be preliminarily approved by the clinic.CONCLUSION: The PDCA management can be applied in the clinical pharmacy as well as in the management of hospital pharmacy.

OBJECTIVE: To probe into the gap between the production cost and retail prices of Chinese patent drugs for references of setting scientific and reasonable drug price.METHODS: The retail prices of the selected drugs were surveyed on the spot;the production prices of the drugs were calculated using the cost accounting theory;statistical method was adopted to compare the equivalence between the production cost and retail price and compute the rational ratio between cost and retail price.RESULTS: Among the 93 high price Chinese patent drugs surveyed,the retail prices of only 6 approached their theoretical retail prices,and the remaining 87 had unreasonably high prices to different extent.CONCLUSION: More importance should be attached to the unreasonably high prices of Chinese patent drugs.The upper limit of the retail prices or daily dose retail prices of Chinese patent drugs should be set so as to keep the unreasonably high drug prices under control.

Objective To investigate the clinical efficacy of thumb-tack needle therapy for senile recurrent oral ulcer of yin deficiency and fire excess type. Method Sixty patients cancer pain were allocated, using a random number table, to observation and control groups,30 cases each. The control group gargled with 10 mL compound chlorhexidine mouthwash 5 min twice daily and the observation group received thumbtack needle therapy 6 hrs once daily, on the left and right sides alternately, in addition to treatment given to the control group. The course of treatment was five days in both groups. The clinical therapeutic effects were evaluated after the completion of treatment. The TCM symptom score and the VAS score were recorded before and after treatment. A comparative analysis was carried out. Result The total efficacy rate was 96.7%in the observation group and 83.3%in the control group. It was higher in the treatment group than in the control group (P<0.05). The TCM symptom score and the VAS score decreased in the observation and control groups after treatment compared with before (P<0.05, P<0.01). They decreased more in the treatment group than in the control group (P<0.05). Conclusion Thumbtack needle therapy has a definite effect on senile recurrent oral ulcer of yin deficiency and fire excess type. It can relieve TCM clinical symptoms and pains in the patients.

BACKGROUND:Pathogenesis of endometriosis involves many factors that ultimately lead to the emergence of endometrial glands and stroma outside the uterine cavity. OBJECTIVE:To review the research progress in the theory of endometrial stem cel s, and to provide suggestions for the pathogenesis and treatment of endometriosis. METHODS:VIP database and PubMed database were retrieved for articles addressing endometriosis stem cel theory, including original research, experimental analysis, case analysis and review, published from January 2005 to October 2015. Keywords wereendometriosis, stem cel sin Chinese and English, respectively. After removal of repetitive articles, 48 articles were included for final analysis. RESULTS AND CONCLUSION:Endometrial stem/progenitor cel s may exist in the endometrium, and these cel s and bone marrow stem cel s are speculated to be involved in the occurrence of endometriosis. Therefore, treatment of endometriosis is targeted to endometrial stem/progenitor cel s and abnormal regulation on signal transduction pathway, which provides new insight into the mechanism of action and treatment of endometriosis.

Objective To know the TCM discipline development situation through analysis on TCM articles based on Chinese Science Citation Database (CSCD) in recent years. Methods Articles about TCM in CSCD from January 2010 to December 2015 were searched by computers. The CSCD literature analysis system was used to conduct metrological analysis from the aspects of publishing time, source journals, cited information, authors, publishing organizations, research themes, and fund support. Results The number of articles published on CSCD was increasing year by year from January 2010 to December 2015. 85.09% of articles focused on the field of general medicine. There were more than 100 CSCD journals included in TCM professional articles. 17 journals published more than 100 TCM professional articles. WANG Yong-yan academician was the author who published the most articles (121 papers). Academic output H index of six authors was more than 5. 31.52% articles in CSCD were cited. Natural Science Foundation of China (including general and youth projects) funded the highest number of articles (12.2%), reaching 1716 articles. Conclusion Analysis on articles from CSCD can outline the development situation of TCM discipline in China. In recent years, the number of TCM articles is increasing; subject integration is good; high-level teams are forming gradually; TCM discipline is developing fast. However, the citation frequency is low; scholar H index is not high; the overall level remains to be improved.

The cognitive conflict between doctors and patients mainly manifests in the different cognition of diseases,the expectation of medical skill and the understanding of medical science.The way to dissolve the cognitive conflict between doctors and patients lies in strengthening exchange and communication between them.

Objective To discuss the causes,the methods of intraoperative prevention and treatment of local recurrence in patients after operation for rectal carcinoma.Methods Fifty-two re-operated patients with local recurrence of rectal carcinoma were analyzed retrospectively.Results In these 52 patients,there were 14 patients with perianus and pelvic cavity recurrence,31 patients with stoma recurrence,4patients with vaginal wall recurrence,2 patients with prostate gland recurrence and 1 patient with implantation in the incision of abdominal wall.Among them,36 patients underwent radical operation,13 patients had palliative resection and 3 patients were treated by enterostomy.The median survival time for the groups who underwent radical(operation) and palliative resection was 33.5(12~80) months and 12(3~23) months respectively.(Conclusions) Patients with local recurrence of rectal cancer should still be given aggressive operative(treatment).Radical resection of the lesions and formal radical lymphadenectomy can prolong patient survival time and improve quality of life.

0.05);(2)In aged women with type 2 diabetes mellitus and the aged control group,the BMD and the level of estrogen decreased and the level of D-pyd increased,compared with those of the aged men with type 2 diabetes mellitus.Conclusion The BMD of aged patients with type 2 diabetes mellitus is not different from that of the aged control group.The change of BMD may be a result of aging.The BMD was lower and D-pyd was higher in aged female than those in male and the possible reason is the decrease of estrogen level.