BACKGROUND:Pathogenesis of endometriosis involves many factors that ultimately lead to the emergence of endometrial glands and stroma outside the uterine cavity. OBJECTIVE:To review the research progress in the theory of endometrial stem cel s, and to provide suggestions for the pathogenesis and treatment of endometriosis. METHODS:VIP database and PubMed database were retrieved for articles addressing endometriosis stem cel theory, including original research, experimental analysis, case analysis and review, published from January 2005 to October 2015. Keywords wereendometriosis, stem cel sin Chinese and English, respectively. After removal of repetitive articles, 48 articles were included for final analysis. RESULTS AND CONCLUSION:Endometrial stem/progenitor cel s may exist in the endometrium, and these cel s and bone marrow stem cel s are speculated to be involved in the occurrence of endometriosis. Therefore, treatment of endometriosis is targeted to endometrial stem/progenitor cel s and abnormal regulation on signal transduction pathway, which provides new insight into the mechanism of action and treatment of endometriosis.

In order to investigate the feasibility of serum creatine kinase (CK) and blood urea nitrogen (BUN) in monitoring pre-competition training of badminton athletes, the pre-competition training load of 20 badminton athletes was studied, and serum CK and BUN were determined before, immediate and next morning after training. The results showed that after intensive training for one week, serum CK levels were significantly increased by 57.53 mmol/L (P<0.05). After regulation of the training intensity, average serum CK levels were increased by 21.79 mmol/L (P<0.05). BUN contents were increased by 0.83 mmol/L on average with the difference being not significant (P>0.05). After intermittent training, there was significant difference in the average increased levels of serum CK in athletes (P<0.05). There was significant difference before and after regulation of training (P<0.05). The increased levels of BUN were 0.78 mmol/L without significant difference (P>0.05). It was concluded that serum CK was one of the biochemical indicators monitoring the training load sensitivity of badminton athletes, but BUN was of little value in monitoring the training load. Both serum CK and BUN recovered slowly after one-week intensive training and intermittent training, suggesting the metabolic mechanism of human body in training needs further study.

Humans ; Kidney Failure, Chronic ; diagnosis ; therapy ; Renal Insufficiency, Chronic ; diagnosis ; therapy

Child ; Humans ; Kidney Diseases ; diagnosis ; therapy ; Kidney Glomerulus

BACKGROUND: Resistin decreases insulin's action. Therefore might be a key molecule in the pathogenesis of type 2 diabetes mellitus in obese subjects.OBJECTIVE: To investigate the correlation of resistin gone expression and insulin sensitivity index (ISI) in type 2 diabetic rat models, and to explore the effect of rosiglitazone on resistin gone expression in a rat diabetic model.DESIGN: Randomized controlled animal study.SETTING: Department of Geratology, the First Affiliated Hospital of Zbengzhou University.MATERIALS: Thirty 2-month-old healthy female Wistar rats were provided by Animal Center of Tongji Medical College,Huazhong University of Science and Technology. Common diets were provided by Animal Center of Tongji Medical College, Huazhong University of Science and Technology, and the gross calorific value was 14.88 J/g (mass fraction: 0.2protein, 0.61 carbohydrate, 0.17 fat); furthermore, high-fat diets were mixed with common diets, saccharobiose, rendered lard, egg, and mild powder, and the gross calorific value was 20.083 J/g (mass fraction: 0.09 protein, 0.51 carbohydrate, 0.38fat). Resistin and β -actin were synthesized in Beijing Salbaisheng Company.METHODS: This study was performed in the First Affiliated Hospital of Zhengzhou University from October 2006 to October 2007. The experimental for animal manipulation conforms to criteria of the university's ethnic committee. Two weeks after adaptability, rats were randomly divided into normal chew group (n=8) and high-fat diet group (n=22). Rats in the high-fat diet group underwent vena caudalis injection with streptozotoein (25 mg/kg), and two days later they were continued fed with high-fat diet. For normal chew group rats were injected with sodium citrate-citrate buffer solution (1 mL/kg) and continued normal chew. After 12 weeks, 15 rats in the high-fat diet group were hyperglycemic and were randomly divided into rosiglitazone (n=8) and high-fat diet diabetic group (n=7). Rats were lavaged with rosiglitazone (2 mg/kg/d) in the rosiglitazone group and with distilled water (8 mL/kg/d) in high-fat diet diabetic group; for normal chew group rats were lavaged with the same volume of distilled water. Rats were studied for four successive weeks.MAIN OUTCOME MEASURES: Fasting serum glucose was measured with glucose oxidase method; insulin by magnetic separation enzyme linked immunosorbent assay; triglyceride and total cholesterol levels by enzymic enzymatic method; ISI was calculated as [1/(fasting serum glucose × fasting insulin)]; resistin mRNA expression in greater omental adipose tissue was examined by RT-PCR; correlation between resistin gene and ISI analyzed by Spearman correlation and multivariate stepwise regression.RESULTS: Fifteen high-fat diet rats and eight normal chew rats were included in the final analysis. Resistin gene expression in the greater omental adipose tissue (A value) was 0.27±0.031 in the high-fat diet diabetic group (0.15±0.018) in the normal chew group, and (0.20±0.024) in rosiglitazone group (P < 0.01). Spearman correlation analysis and multiple stepwise regression analysis showed that resistin gene expression was positively correlated with fasting serum glucose (r=0.271, P < 0.01), fasting insulin (r=0.283, P < 0.01), and ISI (r =0.323, P < 0.01), apparent effects of resistin gene expression on ISI was 0.081.CONCLUSION: High-fat diet and diabetes increases resistin gene expression and rosiglitazone ameliorate its expression.The expression of resistin is correlated with ISI.

The aim of the study was to evaluate the significance of unexplained elevated mater- nal serum alpha-fetoprotein in singleton pregnancies as a prediction of fetal risk. The inclusion criteria for patents with unexplained MSAFP elevations were a MSAFP level 2.0 or greater multiples of the median ( MoM ), a single gestation, a confirmed gestatio- nal age and no fetal malformation or death on ultrasonography. In this study, 991 woman who attended the antenatal clinic at Taejeon Eul Ji Hospital from March, 1996 to March, 1997 were reviewed and data from 79 women with elevated maternal serum alpha-fetoprotein levels were analysed. The 67 of 79 patients with elevated maternal serum alpha-fetoprotein levels had on unexplained elevated MSAFP level. 13 women could not follow up. 54 pregnant women with unexplained elevated MSAFP levels were classified as the index group of singleton pregn- ancy and were matched against a control group. 108 patients with MSAFP levels 0.5 to 2.0 MoM served as control group. The incidence of antepartum hemorrhage ( placental previa ), preterm labor, intrauterine growth retardation ( IUGR ), low birth weight and pregnancy induced hypertension ( PIH ) in two groups was analyzed and the results was subjected to Fisher's Exact Test. None of the patients in the index group had chromosomal abnormalites or birth defect. IUGR occurred in 7 ( 12.96% ) of the index group babies but in only 3 ( 2.78% ) in the control group ( p < 0.02 ). preterm labor occurred in 5 ( 9.26% ) in the index group compared with 2 ( 1.85% ) in the control group ( p < 0.05 ). low birth weight occurred in 3 ( 5.5% ) of the index group babies and in 1 ( 0.9% ) in the control group ( p < 0.1 ). This study suggests that patients with unexplained midtrimester elevations of MSAFP are increased risk for IUGR, preterm labor. But no significance differences were observed in the incidence of low birth weight, antepartum hemorrhage ( placental previa ), PIH.
alpha-Fetoproteins* ; Congenital Abnormalities ; Daejeon ; Female ; Fetal Growth Retardation ; Follow-Up Studies ; Gastroschisis ; Hemorrhage ; Humans ; Hypertension, Pregnancy-Induced ; Incidence ; Infant, Low Birth Weight ; Infant, Newborn ; Obstetric Labor, Premature ; Pregnancy Trimester, Second ; Pregnancy* ; Pregnant Women ; Ultrasonography

Abortion, Habitual ; complications ; Antibodies, Antiphospholipid ; blood ; Antiphospholipid Syndrome ; complications ; pathology ; therapy ; Erythema ; complications ; Heart Valve Diseases ; complications ; Humans ; Kidney Diseases ; complications ; Skin Diseases ; complications ; Thrombosis ; complications

Child ; Early Diagnosis ; Evidence-Based Medicine ; Glomerulonephritis ; diagnosis ; therapy ; Glomerulonephritis, Membranous ; diagnosis ; therapy ; Humans ; Kidney Diseases ; diagnosis ; therapy ; Kidney Glomerulus ; pathology ; Nephrosis, Lipoid ; diagnosis ; therapy ; Renal Replacement Therapy

Humans ; Proteinuria ; diagnosis ; therapy

Antineoplastic Agents ; adverse effects ; Child ; Child, Preschool ; Hematopoietic Stem Cell Transplantation ; adverse effects ; Humans ; Kidney Diseases ; etiology ; pathology ; therapy ; Kidney Neoplasms ; etiology ; pathology ; therapy ; Neoplasms ; complications ; therapy ; Paraneoplastic Syndromes ; etiology ; pathology ; therapy ; Radiotherapy ; adverse effects ; Risk Factors ; Tumor Lysis Syndrome ; etiology ; pathology ; therapy