3.Influence of remifentanil on Cp50 of propofol given by target-controlled fusion for loss of consciousness
Chinese Journal of Anesthesiology 1995;0(10):-
Objective The aim of this prospective randomized study was to compare the effects of remifentanil (R) and fentanyl (F) given by target-controlled infusion (TCI) on the Cp50 of TCI propofol for loss of consciousness ( LOC ) . Methods Sixty-four ASA 1 or II patients aged 20-55 yr undergoing elective cholecystectomy or mastectomy under general anesthesia were enrolled in this study. Their BMI ranged from 18-30 kg?m-2. The patients were randomly allocated to one of four groups with 16 patients in each group: (1) propofol alone (P), (2) P + remifentanil (Cp = 4 ?g?L-1 ) (R4), (3) P + remifentanil (Cp = 7 ?g?L 1 ) (R7) and (4) P + fentanyl (Cp = 4?g?L-1 ) (F). The patients were unpremeditated. Anesthesia was induced with remifentanil or fentanyl and propofol both given by TCI. The plasma concentration (Cp) of remifentanil and fentanyl were fixed in each group. The Cp50 of propofol for LOC was determined by up-and-down sequential trial. Cp of propofol was set at 1.25, 1.50, 1.80, 2.16, 2.59, 3.11, 3.73 and 4.48 mg?L-1 . If a patient did not go to sleep at a certain Cp of propofol, the next patient was tested at a higher concentration conversely if the patient went to sleep a lower concentration was tested in the next patient. The BIS values and hemodynamic changes were recorded before induction and at LOC (no response to verbal command and loss of eyelash reflex). The TCI pump was controlled by pharmacokinetic models developed by Marsh (propofol) Minto ( remifentanil) and Shafer ( fentanyl) . Results The Cp of propofol for LOC in group P was 3.48 mg ? L-1 , significandy higher than that in group F (2.31 mg ? L -1 ), group R4 (2.11 mg?L-1) and group R7 (1.76mg?L-1 ) (P
4.S100 proteins and prostate cancer
Journal of International Oncology 2012;(11):870-872
The S100 proteins are a multi-gene calcium-binding family,which are differently expressed in a variety of tumors.It is found to be associated with tumor invasion and metastasis.As a tumor-associated biomarkers,unraveling the relationship between S100 and prostate cancer progression as well as molecular mechanisms,would provide an important basis for the clinical diagnosis and therapeutic monitoring.
5.Progress of calcium signaling in sensory neurones and neuroglial cell in diabetic peripheral neuropathic dysfunction
Chinese Pharmacological Bulletin 2017;33(3):308-311
Ca2+signaling is fundamental for information process-ing in the peripheral nervous system,which regulates a variety of physiological activities.Ca2+signaling and calcium homeostasis are directly associated with neuropathology.Recently,studies on Ca2+signaling contribute to a deeper comprehension of the path-ogenesis of diabetic peripheral neuropathies,which provide a new research direction for the treatment of diabetic peripheralneuropathies.This review aims to highlight the relationship be-tween calcium signaling,sensory neurones and neuroglial cells in the context of diabetic peripheral neuropathies.
8.Problems in the diagnosis of thyroid papillary and follicular carcinoma.
Chinese Journal of Pathology 2007;36(4):220-223
Adenocarcinoma, Follicular
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diagnosis
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pathology
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Adenoma
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diagnosis
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pathology
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Carcinoma, Papillary
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diagnosis
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pathology
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Carcinoma, Papillary, Follicular
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diagnosis
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pathology
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Cell Nucleus
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pathology
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Diagnosis, Differential
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Humans
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Neoplasm Invasiveness
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Thyroid Gland
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pathology
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Thyroid Neoplasms
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diagnosis
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pathology
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Thyroid Nodule
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diagnosis
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Thyroiditis
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diagnosis
10.Left ventricular multiple myxomas in a neonate.
Chinese Journal of Pediatrics 2005;43(8):630-630