Objective To know the TCM discipline development situation through analysis on TCM articles based on Chinese Science Citation Database (CSCD) in recent years. Methods Articles about TCM in CSCD from January 2010 to December 2015 were searched by computers. The CSCD literature analysis system was used to conduct metrological analysis from the aspects of publishing time, source journals, cited information, authors, publishing organizations, research themes, and fund support. Results The number of articles published on CSCD was increasing year by year from January 2010 to December 2015. 85.09% of articles focused on the field of general medicine. There were more than 100 CSCD journals included in TCM professional articles. 17 journals published more than 100 TCM professional articles. WANG Yong-yan academician was the author who published the most articles (121 papers). Academic output H index of six authors was more than 5. 31.52% articles in CSCD were cited. Natural Science Foundation of China (including general and youth projects) funded the highest number of articles (12.2%), reaching 1716 articles. Conclusion Analysis on articles from CSCD can outline the development situation of TCM discipline in China. In recent years, the number of TCM articles is increasing; subject integration is good; high-level teams are forming gradually; TCM discipline is developing fast. However, the citation frequency is low; scholar H index is not high; the overall level remains to be improved.

Objective To set up a method for determination of the trace amounts of aluminium(Ⅲ) in water samples. Methods Second derivative polarogaphy was used. Results In a solution of acetate buffer(HOAc-NH4OH, pH=5.8), Al(Ⅲ)reacted with Berllon Ⅲ to form a complex and a sensitive polarogaphic adsorptive wave appeared at -0.54 V(vs.SCE). By using the 2nd derivative polarogaphy measyrement, the wave height had a linear relationship with the concentration of Al(Ⅲ)in the range of 0.005-0.300 ?g/ml. The limit of detection was 3.0 ng/ml. RSDs were 5.4%-9.1%. Recovery rates were 92.7%-108.0%. Conclusion The present method is sensitive, accurate with high selectivity and can be applied to the determination of the trace amounts of Aluminium(Ⅲ) in water sample with satisfactory results.

Astrocytes are the most abundant neuronal cells in the central nervous system.It plays an important physiological role.In the process of cerebral ischemia,astrocyte activation is one of the major changes in the central nervous system.The activated astrocytes can play a neuroprotective role through the mechanisms such as maintaining ionic balance,regulating energy metabolism,removing excitatory amino acids,against oxidative stress,and secreting neuroprotective substances.However,astrocyte activation after cerebral ischemia also has its disadvantage.This article reviews the neuroprotective and damage roles of astrocyte activation during cerebral ischemia.It also investigates its regulatory mechanisms in order to provide new ideas for the treatment of ischemic stroke.

ObjectiveTo investigate the effects of alpha-lipoic acid on serum soluble intercellular adhesion molecule-1 (sICAM-1) and high sensitive-C reactive protein (hs-CRP) levels in patients with early diabetic nephropathy (DN).MethodsA total of 61 patients with early DN were randomized into treatment group (n =31 ) and control group ( n =30 ).The two groups were both treated with dietary control and oral hypoglycemic drugs or insulin.Meanwhile,the treatment group was additionally given alpha-lipoic acid 300 mg/d by intravenous infusion for 20 days.The levels of sICAM-1 and hs-CRP in each group were detected.Results The levels of sICAM-1 and hs-CRP were decreased significantly in alpha-lipoic acid treatment group after 20 days of therapy ( [ 198.03 ±23.67] μg/L vs [271.17 ±34.66] μg/L,[5.16 ±0.43] mg/Lvs [7.95 ±0.88]mg/L,P ＜0.01 ).Conclusion alpha-lipoic acid may decrease the expression of slCAM-1 and hs-CRP,and that may be one of the mechanisms to postpone the progress of early DN.

Membrane-associated guanylate kinases (MAGUKs) is a class of postsynaptic density proteins (PSDs) in the postsynaptic dense of the postsynaptic membrane,including PSD-95,SAP-102,PSD-93,and SAP-97.MAGUK family members contain several protein binding sites,and these special binding sites are responsible for mediating a variety of signal transduction.MAGUKs participate in the occurrence and development mechanisms in central nervous system diseases,and has become a topic of general interest of neuroscience.This article briefly reviews the roles of MAGUKs in ischemic brain injury.

Apolipoprotein E (ApoE) has gene polymorphism (ε2,ε3,and ε4).It has been confirmed that ApoE structural and functional abnormlities are closely associated with the hyperlipidemia,formation of atherosclerosis,and its severity,while both hyperlipidemia and atherosclerosis are the risk factors for ischemic stroke.In recent years,although the relationship between the ApoE gene polymorphism and ischemic stroke has been extensively studied,the conclusions are not consistent.This article reviews the correlation studies between the ApoE gene polymorphism and ischernic stroke.

Objective To explore the influences of parent-child attachment security memory activation on college students'general attachment working model. Methods 152 college students were randomly distributed to three groups, among which there were two experimental groups accepting father-child or mother-child memory activation,and one control group accepting non-interpersonal memory activation. Results Mather-child security memory activation significantly increased subjects' scores on others-model of general attachment to females (F= 3.83;P ＜0.05), scores of mather-child security memory activation group were significantly higher than those of fatherchild group ( 7.88 ± 7.24,4.49 ± 7.53; P ＜ 0.05 ) and control group ( 7.88 ± 7.24,4.71 ± 6.83; P ＜ 0.05 ).Father-child security memory activation significantly increased subjects' scores on self-model of general attachment to males (F= 6.35; P ＜ 0.01 ), scores of father-child security memory activation group were significantly higher than that of mather-child group (6.33 ±5.39,2.44 ±6.14; P＜0.01 ) and control group (6.33 ± 5.39,2.59 ±6.10; P ＜ 0.01 ). Conclusion Parent-child attachment security memory activation have major influences on college students' general attachment working model, in which the effect of gender differences provides some inspiration for clinical interferences.

Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of the triglyceride core of circulating triglyceride-rich lipoproteins.LPL can not only affect the lipoprotein level,but also play an important role in the development of atherosclerosis.LPL gene polymorphisms may affect LPL activity,and therefore have both pro-and anti-atherogenic effects.This article reviews the relationship between LPL gene polymorphism and atherosclerosis.

Objective To investigate the estrogen receptor expression character on neurons and glial cells of rat at different ages. Methods Brain sections from normal and injured rats of different ages were chosen to observe the ER immunohistochemistry reaction in cerebrum. Results To compare with normal young rat group,the neurons in hippocampus dentate gyrus of normal aged rat group expressed much less estrogen receptors.There were many ER-positive glial cells appearing in hippocampus of brain injured was rat group,and the positive strain of young injured was much stronger than that of aged rat group.Conclusion The decrease of ER on neurons in dentate gyrus makes the aged more apt to neurodegeneration.The young rats may better utilize the neuroprotection of estrogen against injuries by increasing the amount of ER on glial cells.

Objective To study the expression and clinical significance of p16 and p27kip1 in endometrial carcinoma. Methods 65 cases of endometrial carcinoma were examined by immunohistochemical method for p16 and p27kip1. Results The positive rates of p16 and p27kip1 was 47.7 % and 41.5 % respectively. Both the expression of p16 and the expression of p27kip1 were correlated with histologic differentiation. Conclusions p16 and p27kip1 may play important roles in the development of endometrial carcinoma. They were important in predicting the prognosis and directing the treatment of endometrial carcinoma.