The TNM staging is the most common tumor staging system of lung cancer.The new revisioned 7th lung cancer TNM staging is published by the international association for the study of lung cancer (IASLC) in the 13th world conference on lung cancer.Accurate clinical staging depends on the multi-analysis from medical histroy,clinical examination,imaging examination and invasive test,which has important significance for guiding the treatment of lung cancer.The 7th lung cancer TNM classification has been revised respectively from the primary focus,lymph node metastasis and remote viscera metastasis,so as to make it more accurately corresponding to the prognosis of patients.

0 but was obviously lower than P_ sys in no endoleak. P_ sac approached P_ sys in type Ⅰ and type Ⅳ endoleaks. Some researches showed that P_ sac in type Ⅱ endoleak was higher than that in no endoleak and even approached P_ sys , however the other researches showed that P_ sac in type Ⅱ endoleak was lower than that in no endoleak. Conclusion Postoperative P_ sac dropping greatly eliminated the risk of aneurysm rupture, which symbolized the success of endovascular therapy. Even if the type Ⅰ endoleak of small size might lead to obvious elevation of P_ sac , which necessitates management. The impairment and management tactics of type Ⅱ endoleak remained equivocal, which required further study.

Ocular surface disorders can be caused by the drug-derived toxicity,adverse effect and abuse of eye drops,and usually these disorders present with unspecific and untypical clinical findings.So the eye abnormality induced by topical administration of eye drops often is confused with some corneal inflammatory diseases.In addition,pathogenic mechanisms vary widely due to the different types of eye drops.Therefore,difficulty of diagnosis and poor curative effect often is a challenge for us.Ophthalmologist should be aware of the toxicity derived eye drops on ocular surface.Several noticeable problems of diagnosis and treatment of drug-derived keratopathy were elaborated in this paper.

Objective: To evaluate the value of Cook MOB-15 system in guiding wire insertion during endoscopic retrograde cholangtopancreatography (ERCP). Methods: The clinical data of 51 patients who received Cook MOB-15 system-guided wire insertion during ERCP between Jan. 2005 to Dec. 2007 were retrospectively analyzed. Forty patients who received conventional ERCP catheter for malignant jaundice between Jan. 2002 and Dec. 2004 were taken as control. The successful insertion rates were compared between the 2 groups. Results: The successful insertion rate was 90.2% (46/51) in the Cook MOB-15 system group and 72.5% (29/40) in the conventional group; there was significant difference between the 2 groups (P<0. 05). Conclusion: The Cook MOB-15 system can significantly raise the successful insertion rate in ERCP.

Bone Neoplasms ; diagnosis ; pathology ; Breast Neoplasms ; diagnosis ; pathology ; Delayed Diagnosis ; Diagnostic Errors ; Female ; Frozen Sections ; Humans ; Intraoperative Period ; Retrospective Studies ; Thyroid Neoplasms ; diagnosis ; pathology

Objective To investigate the changes in trafficking of GluRl-containing AMPA (GluR1-AMPA) receptor and GluR2-AMPA receptor from cytoplasm to cell membrane in the spinal cord dorsal horn in a rat model of incisional pain.Methods Thirty-two adult male SD rats aged 6-8 weeks weighing 280-300 g were randomly divided into 2 groups:control group (group C,n =8) and incisional pain group (group Ⅰ,n =24).An 1 cm long incision was made in the plautar surface of right hindpaw according to Brennan et al.in group Ⅰ.Cumulative pain score (CPS) and paw-withdrawal threshold to yon Frey stimuli (PWT) were measured at 3 h and day 1 and 3 afar incision ( T1,2,3 ).The animals were sacrificed after pain behavior assessment.Their lumbar segments of the spinal cord (L3-6) were removed.The expression of GluR1 and GluR2 in cell membrane and cytoplasm in spinal cord dorsal horn was determined by Western blot analysis.The co-expression of Stargazing with GluR1 and GluR2 in the spinal cord dorsal horn was examined by co-immuno-precipitation.Results The CPS was increased and PWT decreased; the GluR1 expression in cytoplasm was decreased while the expression of GluR1 in cell membrane and the co-expression of Stargazing with GluR1 were up-regulated in group Ⅰ as compared with group C.There was no significant change in the expression of GluR2 in cytoplasm and cell membrane and the co-expression of Stargazing with GluR2 in group Ⅰ as compared with group C.Conclusion GluR1-AMPA receptor transfers from cytoplasm to cell membrane but GluR2-AMPA receptor does not in rats with incisional pain.

Adolescent ; Adult ; Burns, Chemical ; therapy ; Female ; Hand Injuries ; chemically induced ; therapy ; Humans ; Hydrofluoric Acid ; adverse effects ; Male ; Retrospective Studies ; Treatment Outcome ; Young Adult

Objective To understand the influence of nursing home service experience on humanistic caring ability of nurses.Methods Using the phenomenological method,15 clinical nurses after participation of nursing home service were interviewed,and the data were analyzed using 7 step Colaizzi method.Results 3 themes were extracted:service experience,the understanding of humanistic nursing care,influence of service experience on humanistic caring ability of nursing.Conclusions The participation of nurses in the nursing home services can promote the humanistic caring ability of nursing,which is a positive way of cultivating the ability of humanistic care ability.

Carcinoma, Hepatocellular ; pathology ; Drug Resistance, Multiple ; Humans ; Liver Neoplasms ; pathology

Objective Colorectal cancer is one of the most common malignancies with high incidence rate. Due to the progress made in diagnostic and therapeutic techniques, even about 30%～50% of patients with no evidence of metastasis on the time of diagnosis have recurrences. The present study is to investigate the carcinoembryonic antigen(CEA) mRNA,CEA protein expression in blood and to evaluate its clinical significance. Methods Peripheral blood samples were collected from 60 patients with colorectal cancer and 40 patients with colorectal polyp and 40 healthy volunteers. CEA mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR) and serum CEA was detected by Enzyme-linked immunosorbent assay. Results The positive rate of CEA mRNA expression in blood samples of 60 patients with colorectal cancer was 68.3%. And one of the healthy volunteers was positive. But three of the 40 patients with colorectal polyp(7.5%) were positive. The positive rate increased with the pathological staging and liver metastasis, but there were no significant relations between the rate and the malignant extent of cell differentiation. Conclusion The expression of CEA mRNA in peripheral blood cells correlates with the pathological staging and liver metastasis of colorectal cancer, and it may be one of potential uses to monitor the micrometastases of tumor. In order to discover the precancerous change,we can detect CEA mRNA expression in blood with polyp of colon.