Objective To research the treatment of cervical HR-HPV infection by vaginal douching with eight kinds of antiviral herbs such as Radix Arnebiae and patrinia.Methods 42 patients with 13 types of cervical HR-HPV infection were selected from Outpatient.27 patients were recruited into a treatment group and 15 patients were recruited into a control group voluntarily.The treatment group was applied with antiviral herbs and the control group was applied with policresulen vaginal suppositories for 3 courses (one course for 7 days per month).The clearance rate and loading dose of 13 types of cervical HR-HPV were observed.Results The negative conversion ratio of the treatment group and the control group was 88.5％ and 15.4％ respectively,and the total efficiency was 100％ and 46.2％ in the treatment group and the control group respectively.The total efficiency between the two groups were significantly different(x2=17.062,P＜0.01).Conclusion The therapeutic effect of antiviral herbs for cervical HR-HPV infection was definite and with no side reactions.

0.05) ,but the BIS and SEF95% were significantly different between the isoflurane group and the desoflurane group (P

Objective To investigate effects of Cocain and amphetamine-regulated transcript(CART) peptides on cerebral ischemic damage and Caspases-3 activities of neurons.Methods 12 mice were randomly divided into CART group and the control group.Mice model of cerebral ischemic was made,after CART group was lateral ventricle injected CART peptides,control group was lateral ventricle injected saline water.Infarction volume was detected by TTC staining.Viability rate of OGD-neurons with CART peptides or salinewater,after mice cortical neuron in vitro was detected by MTT.Caspases-3 activitie was measured by ELISA.Results Infarction volume in the CART group [(0.225?0.044)mm3] was significantly smaller than that in the control group [(0.389?0.055)mm3](P

Objective To observe the effect of motor relearning program (MRP) on balance function of stroke patients.Methods Sixty stroke patients were randomly divided into the MRP group and control group with 30 cases in each group. The patients of the control group were trained with proprioceptive neuromuscular facilitation (PNF) therapy; those of the MRP group were trained with the MRP therapy. The balance function of all patients was assessed with the Fugl-Meyer Balance Function Assessment before and after training.Results After training, the scores of Fugl-Meyer Assessment of all patients increased ( P<0.05), but scores of the patients of the MRP group were significantly higher than that of the control group ( P<0.05).Conclusion The MRP training can improve the recovery of balance function of stroke patients.

Objective To study the relationship of implicit memory and amnesia effect of oral midazolarn premedication and toobserve its anterograde amnesia, the effect on short-term memory and the onset time and out come of retrograde amnesia. Methods60 patients with ASA I - Ⅱ status undergoing abdomen and limb operations were divided into 3 groups with 20 cases each. Group A:oral midazolam 7.5mg;Group B:oral 15mg;Group C:placebo. The patients received combined spinal-epidural anesthesia after oral midazolam. The parameterns of EEG, SEF 95 %, BISwere collected at the same time and the degree and remark of sedation were dome according to OAA/S. The amnesia and implicit memory were investigated with pictures and muddy identified hearing rate 6 hours after operation. Results (1)Twenty min following drug ad dministration the remarks of sedation of group A and B were significantly loWver than that before and that of group C, Which was not significently different between group A and B. ( 2)The amnesia rates tested six hrs after surgery were significantly higher at 30min in group A, 20min in group B than those before treatment and were kept at 70%-80% levels, which in group C was remained zero. (3)The muddy identified hearing rate was not different significantly, among the three groups. (4) The short-term memory was all 100%during the period of drug action. (5)BIS and SEF 95% Were lower 30min after the treatment and all kept at 80 Hz and 20 Hz, which were not different remarkably between group A and B. ConclnsionOral midazolam 7. 5mg has a good effect on anterograde amnesia 30min after treatment, which may not be improved with increament in dosage. It does not lead to retrograde amnesia. The long-term memory, but not short-term memory, was impaired by midazolam. It only affects the explicit memory. Oral premnedication with midazolam can not prevent the awareness during operation totally.

To interpret the traditional Chinese medicine (TCM) theory by the network technology, in order to promote the modernization and programming of studies on compatibility of TCMs. In this paper, efforts were made to express the direct interactions between drugs through the herb-pair network, analyze the community characteristics of the network and its relations with blood-Qi theory, and study the expression of blood-Qi theory on the herb-pair network through prescriptions. According to the findings, the herb-pairs network showed a strong community structure characteristics; Each community is composed of a series of herb pairs with close correlations, and either blood efficacy or Qi efficacy but not both of them. Based on that, the 386 single TCM ingredients involved by the herb-pair network were divided into three types of communities: Blood (B) community, Qi (Q) community and uncertain community. According to the statistical results of 262 prescriptions mapped onto the three types of communities, if a prescription contains single herbs of the Q community, the probability that it contains single herbs o the B community is 99.84%; Meanwhile, there are 140 prescriptions containing single herbs of both the Q community and the B community. The result is completely coincident with the TCM Blood-Qi theory that single herbs belong to both Q and B communities or the B community, because Qi regulation leads to blood regulation, but not vice versa. For example, a patient with hemorrhage due to trauma or blood-heat, Qi tonifying prescriptions may aggravate hemorrhage. In this paper, authors found high-recognition macroscopic network numerical characteristics to network data reference for judging rationality of new prescriptions, and proved human blood and Qi relations from the perspective of data analysis.
Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional

Objective: To study the effects of anterior communicating artery (ACoA) patency on the hemodynamic alteration in contralateral extracranial-intracranial artery after severe stenosis (70% to 99%) or occlusion of unilateral extracranial internal carotid artery (ICA). Methods: Two hundred twenty-eight patients with severe unilateral ICA stenosis or occlusion and normal or stenosis <50% (referred to relatively normal) of the contralateral ICA were enrolled in the study. Among them, there were 113 patients with and 115 without patent ACoA. Color Doppler flow imaging (CDFI) was used to measure the diameters of bilateral proximal ICA, the peak systolic velocity (PSV), the end-diastolic flow velocity (EDV), and the vascular resistance index (RI). Transcranial Doppler (TCD) was used to measure the PSV, EDV, and pulsatility index (PI) of the bilateral middle cerebral artery (MCA) and anterior cerebral artery (ACA). The effects of ACoA patency on the hemodynamics of ICA, MCA and ACA of the relatively normal side were analyzed. Results: Circled digit oneThere was no significant difference in the diameter of ICA on the relatively normal side between the ACoA unpatent group and the ACoA patent group. The PSV and EDV on the relatively normal side in the ACoA patent group were higher than those in the ACoA unpatent group (P < 0.000) while the RI was lower than that in the ACoA unpatent group (P = 0.001). Circled digit twoThe PSV and EDV of MCA and ACA on the ICA relatively normal side in the ACoA patent group were higher than those in the ACoA unpatent group (P = 0.000) and the PI was lower than that in the ACoA unpatent group, however, there was significant difference only in PI of ACA between the two groups (P = 0.007). Circled digit oneThe correlation analysis showed that the mean velocity of MCA and ACA on the relatively normal side was positively correlated with that of ICA (r = 0.587, 0.346, P = 0.000). Conclusion: When one side of ICA is severely stenotic or occlusion, the ACoA patency will directly influence the hemodynamic alteration of the extracranial ICA as well as MCA and ACA on the other side.

Objective: To investigate the effect of contralateral vertebral arterial hemodynamics after unilateral vertebral artery stenting and its relationship with restenosis. Methods: A total of 155 patients with severe stenosis (70-99%) at the origin of unilateral vertebral artery confirmed by digital subtract angiography (DSA) and underwent stent implantation were recruited in the study. According to the contralateral vertebral artery lesions, they were divided into 3 groups: normal group (n = 71), severe stenosis group (n = 29 ) and occlusion group (n = 55). Carotid color Doppler flow imaging (CDFI) and transcranial Dopper (TCD) were performed before stenting, within 1 week, and 1 year after stenting. Peak systolic velocity (PSV) and end diastolic velocity (EDV) of vertebral arteries at the original part (OS), intervertebral segment(IV) and intracranial (IC) segments were recorded. Results: Circled digit oneCompared to the normal group within 1 week after stenting, the PSVOS and EDV OS of the original part of the stent side vertebral artery in the severe stenosis group increased slightly, but there were no significant differences; the PSVOS and EDVOS in the occlusion group increased significantly (P < 0.05). The PSV and EDV of the intervertebral and intracranial segments at the stent side in the severe stenosis group and the occlusion group were significantly higher than those in the normal group (P < 0.05). The above parameters on the stent sides in the occlusion group were slightly higher than those in the severe stenosis group, but the difference was not statistically significant. Circled digit twoOne year after stenting, 79 patients were followed up with ultrasound. There were 35 patients in the normal group, 15 in the severe stenosis group, and 29 in the occlusion group. The severe stenosis group and occlusion group were combined and analyzed (lesion group). PSVos and EDVos of stent side in the lesion group were significantly higher than those in the normal group; the restenosis rate of stent side in the normal group was 34.3% (12/35), while that in the lesion group was 56.8% (25/44). There were significant difference between the two groups (P < 0.05). Circled digit threeMultivariate logistic regression analysis showed that the severe lesion (severe stenosis or occlusion) of the contralateral vertebral artery was an independent risk factor for restenosis on the stent side (OR, 3.261, 95% CI: 1.174 to 9.058). Conclusion: When there is severe lesions at the original part of bilateral vertebral artery, the stent side of vertebral artery after stenting may immediately play a compensatory role for the blood flow on the non-stent side, however, this compensatory role is also one of the risk factors for occurring in-stent restenosis.

Objective: To evaluate the effect of atorvastatin on the prevention of restenosis after vertebral artery origin stenting with color Doppler flow imaging (CDFI). Methods: A total of 59 patients with complete clinical data underwent unilateral vertebral artery origin stenting were recruited in the study. The patients were divided into drug (n =29) and non-drug (n =30) groups according to whether they took atorvastatin (20 mg/d) or not. All the patients were detected by CDFI before and at 1, 6, and 12 months after stenting. The peak systolic velocity (PSV) at the proximal (PSVOS) and intervertebral segments of vertebral artery (PSVIV) were recorded and the ratio of PSVOS/PSVIV was calculated. Digital subtraction angiography (DSA) showed that the in-stent stenosis rate ≥50% was determined as postoperative restenosis. The incidence of restenosis and hemodynamic changes were compared between the two groups. Results: Circled digit oneThe restenosis rates of the drug and non-drug groups at 6 months after stenting were 20.7% (6/29) and 36.7% (11/30) respectively (P >0.05); the restenosis rate (50.0%) of the non-drug group(50%) was significantly higher than that of the drug group (20.7%) at 12 months after stenting (P < 0.05). Circled digit twoThe PSV OS and PSVOS/PSVIV of the patients in both groups at 1 month after stenting were improved more significantly than those before the procedure. PSVOS(187±18 cm/s, 179±20 cm/s) and PSVOS/PSVIV(3.93±0.59, 3.24±0.48) were relatively increased in the non-drug group at 6 months after the procedure, but there was no significant difference. PSVOS (209±21 cm/s, 159±16cm/s) and PSVOS/PSVIV (4.34±0.65, 2.86±0.36) in the non-drug group at 12 months after stenting were significantly higher than those in the drug group. There was significant difference between the two groups (P < 0.05). Conclusions: Atorvastatin can decrease the restenosis rate after vertebral artery stenting. With the prolonged time of drug treatment, it may affect the hemodynamic changes in the abnormal vessels.

Objective:To investigate the effects of iron sucrose combined with recombinant human erythropoietin(EPO)on perioperative anemia and early functional recovery in elderly patients with intertrochanteric fractures.Methods:A retrospective comparative analysis was performed on 78 elderly patients who received PFNA treatment for intertrochanteric fractures in our hospital from July 2016 to December 2018.In the observation group, 40 cases were treated with iron sucrose combined with erythropoietin during the perioperative period.No perioperative intervention measures were taken for the control group.Hemoglobin(Hb)levels at 1, 3, 5, 7 days and before discharge and Harris scores of hip joints before surgery, 2 weeks and 3 months after surgery were compared between the two groups.Results:Hb levels were higher in the observation group than in the control group at 5 d[(98.8±8.6 g/L vs.92.2±8.5 g/L, t=3.389, P=0.001)]and 7 d[(105.4±8.9)g/L vs.(94.8±8.5)g/L, t=5.370, P=0.000]after surgery and before discharge[(115.4±8.6)g/L vs.(100.6±8.2)g/L, t=7.771, P=0.000]. Harris scores were higher in the observation group than in the control group 3 months after surgery(82.4±3.8 vs.75.8±2.5, t=8.933, P=0.000). Pearson' s correlation analysis showed that Hb levels at 5d and 7d after surgery were positively correlated with Harris scores at 3 months after surgery.Hb levels before discharge had an effect on Harris scores at 3 months after surgery. Conclusions:The combined administration of iron sucrose and EPO perioperatively can promote postoperative Hb recovery, reduce the incidence of anemia, accelerate early functional recovery and improve the quality of life in elderly patients with intertrochanteric fractures.