Objective:To investigate prevalent aeroallergens in ChongQing and their sensitization risk factors in children with allergic diseases,especially asthma.Methods:Skin prick tests with 13 standardized aeroallergens and questionnaires were used.A total of 298 patients,aged between 4~15 years and were diagnosed with allergic asthma and or allergic rhinitis,were investigated.Results:The total positive rate of allergen was 84.9%(253/298).The prevalence of aeroallergens were following:the first was house dust mite,cockroach followed,the third one was cat dander;the positive family history of asthma was 69.6%(116/230),asthma and rhinitis accounted for 67.2%(78/116)。Multivariate logistic regression analyses revealed that house dust mite was an independent risk factors for asthma(odds ratio Value(OR):2.602,95%CI:1.672～7.488),air conditioning had strong relationship with it(OR:1.659,95%CI:1.139～5.942).Conclusion:House dust mite is the major allergen of allergic diseases,especially asthma in ChongQing.Air conditioning is one of important risk factors for house dust mite sensitization.

Objective:To prepare Pingwei dispersible tablets and establish a method for the determination of atractylodin. Meth-ods:HPLC was performed on a Kromasil C18 column(250 mm × 4. 6 mm,5 μm)using methanol-water(75:25)as the mobile phase at a flow rate of 1 ml·min-1 . The detection wavelength was at 340nm. The column temperature was 30℃ and the injection volume was 10 μl. Results:The optimized formula of the tablets was as follows:the proportion of inner disintegrant microcrystalline cellulose,out-side disintegrant carboxymethyl cellulose sodium and HPMC was 40%,9% and 2%,respectively. The adhesive was 2% HPMC in 70% ethanol,and 1. 5% magnesium stearate was used as the lubricant. The linear range of atractylodin was 0. 100 6-0. 503 0 μg(r=0. 999 9),and the average recovery was 99. 3%(RSD=0. 9%,n=6). Conclusion:The formula and the preparation process of the tablets are reasonable and the content determination method is simple,accurate and specific,which can be used in the quality control of Pingwei dispersible tablets.

Coronary Artery Disease ; diagnosis ; therapy ; Humans ; Tomography, Optical Coherence ; methods ; Treatment Outcome

Moyamoya disease is a chronic progressive cerebrovascular disease. Its main manifestation is bilateral internal carotid artery progressive stenosis w ith abnormal vascular netw ork formation of the compensatory hyperplasia in brain base. The pathological mechanism of moyamoya disease is not clear. Grow ing evidence has suggested that immune inflammation may play an important role in its occurrence and development process. Abnormal expression of various inflammatory cytokines and immune proteins can be observed in patients w ith moyamoya disease. This article review s the possible mechanism of immune inflammation in moyamoya disease in recent years.

Cerebral small vessel disease (SVD) is an important subtype of cerebrovascular disease. It is also one of the major reasons for resulting in vascular cognitive impairment or dementia in the elderly. SVD is a small arteriovenous lesion in subcortex caused by a variety of causes, mainly causing subcortical lacunar infarction, white matter damage, microblecds and other pathological changes. There is evidence that vascular endothelial function and blood-brain barrier damage may result in small vessel structures and perivascular changes, which may be the initial factors.of causing SVD. Genetic susceptibility is also one of the risk factors that can not be ignored.

The changes of immune system following stroke mainly includes the local inflammatory responses of brain tissue and the systemic immunological changes, The former may exacerbate brain damage following stroke, the latter may increase the susceptibility to infection, and thus impact on brain function recovery and prognosis. Stroke interferes with the normal balance between the nervous system and the immune system, and its mechanism remains unclear. This article reviews the stroke-indnced immunological alterations and their mechanisms,as well as the corresponding treatment strategies in clinical practice.

Superficial siderosis of the central nervous system is a seldom disease in clinical practice. Its most common clinical manifestations are hearing loss and ataxia. It is a hemosiderin deposition in the surface of the brain and spinal cord after chronic subarachnoid hemorrhage. Magnetic resonance imaging can make the diagnosis. However, further research and clinical verification are needed.

The patients with stroke is often accompanied by malnutrition, its causes include eating less, increased catabolism, and intestinal dysfunction, etc. Malnutrition can not only aggravate the extent of brain damage in patients with stroke, but also increase the incidence of complications, and thus affecting the course and prognosis of stroke. Therefore, correct evaluation of the nutritional status in stroke patients, choosing the appropriate nutrient timing and nutritional support methods have important significance. Among a variety of nutritional assessment methods, the scored Patient-Generated Subjective Global Assessment can quickly identify malnutrition in stroke patients. Early enteral nutrition support, including oral nutritional supplements, nasogastric tube feeding and percutaneous endoscopic gastrostomy, can significantly improve the prognosis in stroke patients. Among them, nasogastric tube feeding is the first choice for nutritional support in stroke patients.

Recently diverse magnetic resonance imaging technology is used in glioma grading,which based on the theory of Gaussian distribution.Diffusion kurtosis imaging emerges as an extension of DWI and DTI,which could reflect the real and actual hydron non-Gaussion distribution of tumor and peritumoral microenvironment.Displaying the correlation with immunohistochemical label Ki-67,DKI convinces more scholars inland and abroad with its practicability.

Objective To study the awareness and behaviors for patients′ privacy protection among undergraduate nurses. Method By using questionnaire, the survey was conducted among 100 undergraduate nurses. Results The score on the awareness and behaviors for patients′privacy protection was (15.84 ± 1.25). There were significant differences in the awareness and behaviors among different internship time, gender and hospitals (all P<0.05). Conclusions Awareness and behaviors for patients′privacy protection among undergraduate nurses are at a medium level. It is a demand to enhance the education on patients′privacy protection , especially to male undergraduate nurses and at the beginning of internship so as to prevent the patient-nurse disputes.