Excitatory Amino Acids ; secretion ; Humans ; Neurotransmitter Agents ; secretion ; Pain, Postoperative ; etiology ; metabolism ; prevention & control

Atherosclerosis ; Humans

Aged ; Female ; Hemangioma, Cavernous ; complications ; Humans ; Kasabach-Merritt Syndrome ; complications ; Liver Neoplasms ; complications

Breast Neoplasms ; etiology ; genetics ; pathology ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Epithelial Cells ; pathology ; Female ; Fibroadenoma ; genetics ; Humans ; Loss of Heterozygosity ; Phyllodes Tumor ; etiology ; genetics ; pathology ; Stromal Cells ; pathology

No abstract available.
Humans ; Quality of Life* ; Self Care*

BACKGROUND:Extracelular matrix degradation and remodeling is the common pathway of a variety of pathological and physiological processes, and is invovled in the pathogenesis of a variety of oral diseases. OBJECTIVE: To analyze the role of extracelular matrix remodeling folowing celular apoptosis in recurrent aphthous ulcer and the therapeutic effect of baicalin, so as to provide references for new drug development and clinical treatment. METHODS: Forty Sprague-Dawley rats were randomly divided into four groups: control, recurrent aphthous ulcer model, low-dose baicalin and high-dose baicalin groups. Rat models were established using oral mucosal homogenate plus Freund’s immunoadjuvants in the recurrent aphthous ulcer model, low-dose baicalin, and high-dose baicalin groups. Rats in low-dose baicalin and high-dose baicalin groups were intragastricaly administered 10 mg/kg and 100 mg/kg of baicalin respectively for 14 days, once per day. RESULTS AND CONCLUSION:Compared with the control group, serum superoxide dismutase level was distinctly decreased, however, malondialdehyde level distinctly increased; the expression levels of Bax, Caspase3 and matrix metaloproteinase 2/9 were increased, but the expression of Bcl2 was decreased in the recurrent aphthous ulcer model group. The abovementioned indicators of rats returned greatly towards normal levels in the low dose baicalin and high dose baicalin groups, and there was significant difference in the effects of different doses of baicalin on these indicators. These results suggest that baicalin treats recurrent aphthous ulcer mainly through inhibiting extracelular matrix degradation and remodeling.

BACKGROUND:Pathogenesis of endometriosis involves many factors that ultimately lead to the emergence of endometrial glands and stroma outside the uterine cavity. OBJECTIVE:To review the research progress in the theory of endometrial stem cel s, and to provide suggestions for the pathogenesis and treatment of endometriosis. METHODS:VIP database and PubMed database were retrieved for articles addressing endometriosis stem cel theory, including original research, experimental analysis, case analysis and review, published from January 2005 to October 2015. Keywords wereendometriosis, stem cel sin Chinese and English, respectively. After removal of repetitive articles, 48 articles were included for final analysis. RESULTS AND CONCLUSION:Endometrial stem/progenitor cel s may exist in the endometrium, and these cel s and bone marrow stem cel s are speculated to be involved in the occurrence of endometriosis. Therefore, treatment of endometriosis is targeted to endometrial stem/progenitor cel s and abnormal regulation on signal transduction pathway, which provides new insight into the mechanism of action and treatment of endometriosis.

CD163 is one of transmembrane glycoproteins expressed only in activated monocyte-macrophage cell membrane, which acts as a marker of activated macrophages. In sepsis, CD163 activates the intracellular signal transduction pathways in macrophages,regulates TNF-α, IL-10 and IL-6 expression, have antiinflammatory and antioxidant effects in the inflammatory process. Soluble CD163 (sCD163) is a soluble form of CD163 ,which could play anti-inflammatory and immunoregulatory effects by inhibiting T cells proliferation and activation. Serum concentration of sCD163 may be highly increased when severe infection. Detection of serum sCD163 is helpful to diagnose sepsis,and to evaluate the prognosis of severe infection and sepsis.

Objective To know the TCM discipline development situation through analysis on TCM articles based on Chinese Science Citation Database (CSCD) in recent years. Methods Articles about TCM in CSCD from January 2010 to December 2015 were searched by computers. The CSCD literature analysis system was used to conduct metrological analysis from the aspects of publishing time, source journals, cited information, authors, publishing organizations, research themes, and fund support. Results The number of articles published on CSCD was increasing year by year from January 2010 to December 2015. 85.09% of articles focused on the field of general medicine. There were more than 100 CSCD journals included in TCM professional articles. 17 journals published more than 100 TCM professional articles. WANG Yong-yan academician was the author who published the most articles (121 papers). Academic output H index of six authors was more than 5. 31.52% articles in CSCD were cited. Natural Science Foundation of China (including general and youth projects) funded the highest number of articles (12.2%), reaching 1716 articles. Conclusion Analysis on articles from CSCD can outline the development situation of TCM discipline in China. In recent years, the number of TCM articles is increasing; subject integration is good; high-level teams are forming gradually; TCM discipline is developing fast. However, the citation frequency is low; scholar H index is not high; the overall level remains to be improved.

Objectives:To study the relationship between the expression of PS2 protein and estrogen receptor(ER) and progesterone receptor(PR) ,c-erbB2 status and prognosis in breast cancer.Methods:PS2 protein expressions in 52 cases of breast cancer were detected by immunohistochemical method.Results:The positive rate of PS2 protein was 59.6 %(31/52) in 52 patients.There was significant correlation between PS2 protein and menopausal status,ER status,PR status respectively.Tumor size,clinical stage and lymph node status were not significantly related with the expression of PS2 protein.Patients with PS2 protein positive expression had higher 5-year-survival rate than those with PS2 protein negative expression.Conclusion:PS2 protein appears to be an independent and valid prognostic factor of breast cancer,and detection of PS2 protein expression was useful for treatment of breast cancer.