Adiponectin (APN) is an insulin sensitizing protein with protective effect secreted by adipose tissue.It has the effects of regulating glucose and lipid metabolism,protecting vascular endothelial function,promoting angiogenesis,and anti-inflammation,etc.It plays an important protective effect in cerebrovascular diseases.This article reviews APN and its effect in ischemic stroke.

Objective:To evaluate the expression of EGFR and gene nm23H1 and their relation to the tumor oncogenesis and progress of cholangiocarcinoma.Methods:SABC immunohistochemistry was used to detect the expression of EGFR and nm23H1 in cholangiocarcinoma and cholangitis tissue.Results:The positive rate of nm23H1 in cholangiocarcinoma was lower than cholangitis(P

Objective To investigate the efficacy of ultrasound guided injection of embryonic inactivation in the treatment of ectopic pregnancy.Methods Eighty cases of ectopic pregnancy were selected in the Second Hospital Affiliated to Fujian Medical College from June 2011 to June 2014, in accordance with the order of admission, they were divided into two group of each 40 cases.The control group carries on the conservative treatment, intramuscular injection of methotrexate (MTX) , while the observation group in transvaginal ultrasonography guided implantation of MTX.The curative effect of two groups was Compared.Results The observation group effective rate of the treatment was 92.5％ (37/40), significantly higher than that of control group(62.5％ (25/40) ,x2=10.32 ,P＜0.01).The patients of two groups with no due mass rupture and transit operation.The observation group mass less than or equal to 2 cm disappear time required was (15.4±2.6) d,significantly shorter in the control group((27.1±3)d,t=18.64,P＜0.01).Serum β-human chorionic gonadotropin decreased to normal time required was (13.7±6.1)d, significantly lower than that of the control group((18.4±7.2) d,t=3.15 ,P＜0.01).The adverse reaction rate in the observation group was 10％ (4/40), significantly lower than that of the control group (32.5％ (13/40), P =0.028).Conclusion Ultrasound guided injection of embryonic inactivation treatment for ectopic pregnancy have curative effect, can effectively improve the clinical symptoms and reduce adverse reaction.

OBJECTIVE:To provide basis and advices for the research of new traditional Chinese medicine (TCM) in Sichuan province.METHODS: The data of the application and registration of TCM treated as new medicine and new TCM in Sichuan province from 2001 to 2006 were analyzed and evaluated statistically.RESULTS: The number of the application was growing but new medicine was countable with low approval rate.The research institutes hadn’t played a prominent role in the research of new drug.CONCLUSION: The innovation and research of original TCM and the transformation of achievement should be enhanced to achieve the goal of a strong province on TCM.

Objective To investigate the neuroprotective effect of adiponectin on rats with cerebral ischemic-reperfusion injury and explore its possible mechanism.Methods Sixty-four SD rats were divided into normal group (C) and diabetic group (D) randomly.Type 2 diabetic rats model were made by high-fat diet before the middle cerebral artery occulation model (MCAO) surgery.Each group was divided into two subgroups.CAPNand DAPN groups were given exogenous recombinant globular adiponectin via jugular vein one hour after ischemic-reperfusion injury,C0 and D0 groups were given the same amount of normal saline at the same time.Body weight and blood glucose of the rats were measured before ischemia.We also evaluated the neurological function of rats 24 h after treatment according to Longa criteria and observed the morphological changes of cells in brain area via HE staining.The vascular density in ischemic-reperfusion injury area was detected through 3D confocal image system 2 weeks after the treatment.Results The body weight of diabetic rats was significantly lower than normal rats((284.06 ± 19.85)vs (220.31 ±21.87) g,t =8.634,P =0.000).Blood glucose of diabetic rats before ischemia was significantly higher than normal rats ((4.36±0.13)vs(22.92 ± 1.58) mmol/L,t =11.74,P =0.000).Compared with C0 group,the neurological function score of CAPN group was lower(2.29 ± 0.69 vs 17.0 ± 0.69,t =2.186,P =0.038).Compared with D0 group,the neurological function score of DAPN group was lower(2.89 ± 0.33 vs 2.40 ±0.51,t =2.567,P =0.018),too.HE staining showed that the neuronal injury were milder in CAPN,DAPN group,compared with C0,D0 group,respectively.Adiponectin increased the vascular density of ischemic cortex inC group ((2014.58±61.18)/0.002 mm2 vs(3211.95 ±71.64)/0.002 mm2,t =12.16,P=0.023) and D group ((502.86 ± 30.43)/0.002 mm2 vs (1426.69 ± 97.24)/0.002 mm2,t =25.64,P =0.001).Adiponectin increased the vascular density of ischemic striatum in C group (472.59 ± 4.78)/0.002mm2 vs (736.60 ±104.90) /0.002 mm2,t=7.11,P=0.007) and D group (432.04 ±4.65)/0.002 mm2 vs (1780.75 ± 74.54)/0.002 mm2,t =51.08,P =0.000).Conclusions Adiponectin exerts the neuroprotective effect on cerebral ischemic-reperfusion injury in normal and diabetic rats.And it may protect the brain through promoting angiogenesis.

Objective To investigate the actual pollution status of heating-ventilating-air conditioning(HVAC) systems in five-star grade hotels in Beijing. Methods Seven sets of centralized HVAC system from five five-star grade hotels in Beijing were selected for sampling monitoring and videotaping in situ from August 2003 to October 2003. Results There were six sets HVAC systems seriously polluted and one set was in moderately polluted according collected dust weight. The total counts of bacteria in the dust were in medium pollution grade in four sets of HVAC systems; The total quantity of fungus in the dust were in medium pollution grade in five sets of HVAC systems; The video materials showed that inside the air duct there were fungus, construction rubbish and deposit of large quantity of dust. Conclusion The HVAC systems of those five hotels were seriously polluted.

Objective To evaluate endos copy combined with peritoneal lavage for the treatment of severe acute biliogen ic pancreatitis(SAP).Methods 62 cas es of SAP were randomized into endoscopic intervention group (32 cases) and con trol group (30 cases) treated conservatively. The endoscopic group were treated with ERCP and EST,and BUS guided abdominal paracentesis drainage and antibiotic lavage. Abdomi nal pain, amylase level in blood and urine, WBC counts, average hospital stay, t he operation rate within one month, complication, mortality and curative rate in patients of the two groups were recorded and compared.Results Results in endoscopic group were superior to contro l group (all P

Objective To assess the efficacy of endoscopic papillary balloon dilatation(EPBD)for bile duct stones.Methods Four hundred and six patients with bile duct stones who had been treated by ERCP from January 2000 to December 2000 were divided into EST group(n=205)and EPBD group(n=201)according to the admission time.The differences upon incidences of early and long-term complications,clearance rate of bile duct stones between the 2 groups were detected.Results There was no significant difierence upon the incidence of early complications.clearance rate of bile duct stones and incidence of pancreatitis between the 2 groups(χ2=0.540.0.058.0.010,P＞0.05).The incidence of eholecystitis and recurrence rate of bile duet stones in EST group were significantly higher than those in EPBD group(χ2=4.002,4.263,P＜0.05).Conclusions The incidence of cholecystitis and recurrence rate of bile duct stones after patients being treated by EPBD are significandy lower than EST.EPBD is superior to EST in protecting the sphincter of Oddi.

Objective To study the effects of endothelin (ET) and Xuesaitong injection on hepatic, renal and myocardial tissues after bile duct ligation (BDL) in rabbits. Methods Seventy-two rabbits were randomly divided into three groups: BDL group (24 rabbits), BDL+Xuesaitong injection group (24 rabbits), and sham operation group (24 rabbits). Each group was subdivided into four subgroups of postoperative 3, 6, 9 and 12 d (6 rabbits in each subgroup). Automatic biochemical analysis equipment was used to detect the levels of serum TBIL, ALT, BUN and Crea. The levels of ET in plasma, hepatic, renal and myocardial tissues were measured with radioimmunological method. Results The levels of ET in plasma, hepatic, renal and myocardial tissues in both BDL group and BDL+Xuesaitong injection group were higher than those of sham operation group (P

0.05 ), the postoperative complication and mortality rate of PG group were 13.7% and 6.8%, of TG group was all 6%.Conclusions:Proximal and total gastrectomy treatment does not significantly influence the prognosis of patients with cardia and esophgogastric junction cancer in progressive stage.