1.Pilot Study of Antioxidant Mixture (Vitamin E, Pycnogenol and Squalene) in Healthy Smokers: Inhibitory Effect on Oxidative DNA Damage
Satoshi OHNO ; Yumiko OHNO ; Nobutaka SUZUKI ; Nobuhide KAWAGOE ; Takanari ARAI ; Masaki INOUE
Japanese Journal of Complementary and Alternative Medicine 2007;4(1):33-36
Oxidative stress is considered to contribute to degenerative disease. The urinary excretion of the DNA repair product 8-hydroxy-2′-deoxyguanosine (8-OHdG) is proposed as a noninvasive biomarker of current oxidative stress in vivo. We investigated the effect of an antioxidant mixture on urinary 8-OHdG excretions in 12 otherwise healthy smokers. During the intervention period for 2 weeks, subjects consumed four capsules of PICACE® (Pycnogenol® 15 mg/capsule, Vitamin E; 56.1 mg/capsule, Squalene; 138.9 mg/capsule) per day. On days 0 (pre-internal use), 3, 7, 14, and 44, morning urine samples were collected. The urinary 8-OHdG was measured using high-performance liquid chromatography (HPLC). The urinary 8-OHdG level on day 3 was significantly reduced compared to day 0. The level of 8-OHdG after a washout period for PICACE® (days 44) returned to day 0 baseline. These preliminary data suggest that PICACE® supplements can protect smokers from oxidative stress and possibly reduce disease risk caused by free radicals associated with smoking.
2.An audit of transmucosal immediate-release fentanyl prescribing at a university hospital
Shinsuke Hara ; Isseki Maeda ; Yoichi Matsuda ; Yumiko Ohno ; Hitoshi Tanimukai ; Satoru Tsuneto ; Hiroko Kadowaki ; Manabu Takegami ; Yoshihiro Miwa
Palliative Care Research 2015;10(1):107-112
Transmucosal Immediate-Release Fentanyl(TIRF)can be a key-drug for breakthrough cancer pain. Prescription audit is needed because there are concerns about tolerance or serious adverse events including respiratory suppression and addiction due to inappropriate use of these drugs. The aim of this audit study is to evaluate appropriateness of TIRF prescriptions, reasons of violation, and adverse events in the real-world setting. A retrospective chart review was conducted in 31 patients who had breakthrough cancer pain and were treated with TIRF. A 2-step algorithm was generated:baseline pain and administration situation of other opioid rescues. TIRF was prescribed appropriately in six patients(19.4%). Reasons of violation were as follows:prescriptions only for using same drug with around-the-clock opioids(fentanyl transdermal patches, n=19), and patients could take oral medicines and use of morphine or oxycodone rescues would be preferable(n=12). TIRF was initiated with a minimum dose in all patients and no serious adverse events were observed. Although TIRF was used widely for breakthrough cancer pain, prescription was not necessarily done appropriately. Detailed assessment of breakthrough cancer pain and consideration of the use the other rescue medication would be required.
3.A case of Post-operative Complication and Chronic Pain Successfully Treated with Kampo Medicine for Qi Disturbance
Yumiko KIMATA ; Nobuyasu SEKIYA ; Yuji KASAHARA ; Atsushi CHINO ; Yoshiro HIRASAKI ; Keiko OGAWA ; Hideki OKAMOTO ; Keigo UEDA ; Kenji OHNO ; Takao NAMIKI ;
Kampo Medicine 2011;62(1):48-52
We experienced a case of post-operative complication and chronic pain due to left pyeloplasty and uterine myomectomy successfully treated with Kampo medicine. A 55-year-old woman underwent pyeloplasty for ureteropelvic junction obstruction, and ureteral stent for ureteral stenosis caused by synechia after uterine myomectomy. She suffered from post-operative complication and chronic pain, which was becoming severe, and had a depressed mood. She visited our outpatient clinic for Kampo therapy. We prescribed bukuryoingohangekobokuto on the diagnoses such as qi deficiency, qi stagnation, and water retention. Her symptoms disappeared with this formulation. This case suggests the importance of considering qi disturbance when we treat patients with chronic pain using Kampo medicine.
4.Six Cases with 'Honton' Disease Successfully Treated with Combination of Goshuyuto Extract and Ryokeijutsukanto Extract
Yuji KASAHARA ; Yutaka KOBAYASHI ; Atsushi CHINO ; Nobuyasu SEKIYA ; Takao NAMIKI ; Kenji OHNO ; Masaki RAIMURA ; Sumire HASHIMOTO ; Keiko OGAWA ; Hirokuni OKUMI ; Yumiko KIMATA ; Yoshiro HIRASAKI ; Toshiaki KITA ; Katsutoshi TERASAWA
Kampo Medicine 2009;60(5):519-525
We report six cases with honton disease successfully treated with a combination of goshuyuto extract and ryokeijutsukanto extract. Five of the cases were diagnosed as panic disorder, and the remaining case as generalized anxiety disorder. All six cases complained of palpitation, nausea, dizziness, headache and anxiety attacks. We diagnosed them as a hontonto (Zhouhou fang) indication. Their various complaints disappeared after combination therapy with those extracts. Furthermore, efficacy of the combination therapy was proven to be equal to hontonto. These cases suggest that the combination therapy with goshuyuto extract and ryokeijutsukanto extract is useful in place of hontonto.
5.Six Cases with \lqHonton\rq Disease Successfully Treated with Combination of Goshuyuto Extract and Ryokeijutsukanto Extract
Yuji KASAHARA ; Yutaka KOBAYASHI ; Atsushi CHINO ; Nobuyasu SEKIYA ; Takao NAMIKI ; Kenji OHNO ; Masaki RAIMURA ; Sumire HASHIMOTO ; Keiko OGAWA ; Hirokuni OKUMI ; Yumiko KIMATA ; Yoshiro HIRASAKI ; Toshiaki KITA ; Katsutoshi TERASAWA
Kampo Medicine 2009;60(5):519-525
We report six cases with honton disease successfully treated with a combination of goshuyuto extract and ryokeijutsukanto extract. Five of the cases were diagnosed as panic disorder, and the remaining case as generalized anxiety disorder. All six cases complained of palpitation, nausea, dizziness, headache and anxiety attacks. We diagnosed them as a hontonto (Zhouhou fang) indication. Their various complaints disappeared after combination therapy with those extracts. Furthermore, efficacy of the combination therapy was proven to be equal to hontonto. These cases suggest that the combination therapy with goshuyuto extract and ryokeijutsukanto extract is useful in place of hontonto.
Combined Modality Therapy
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Cases
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Treated with
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Six
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Combined
6.A Case of Neurogenic Bladder Successfully Treated with Hangebyakujutsutemmato
Sumire HASHIMOTO ; Nobuyasu SEKIYA ; Yuji KASAHARA ; Hirobumi SHIMADA ; Yumiko KIMATA ; Hirokuni OKUMI ; Keiko OGAWA ; Masaki RAIMURA ; Kenji OHNO ; Yoshiro HIRASAKI ; Atsushi CHINO ; Takao NAMIKI ; Katsutoshi TERASAWA
Kampo Medicine 2009;60(6):607-610
We report a case of neurogenic bladder that was successfully treated with hangebyakujutsutemmato. A 71-year-old Japanese male had difficulty in micturition because of a neurogenic bladder. We utilized hangebyakujutsutemmato on the assumption that he was suffered from qi deficiency, water retention, and qi stagnation. His symptoms disappeared with this therapy. Although kidney tonifying formulae, dampness-draining formulae, and blood stasis-resolving formulae are popular prescriptions for nerurogenic bladder, hangebyakujutsutemmato may be also effective for cases with qi deficiency, water retention, and qi stagnation.
Bladder, Neurogenic
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Treated with
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Water
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deficiency
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g <3>
7.Six Cases with ‘Honton’ Disease Successfully Treated with Combination of Goshuyuto Extract and Ryokeijutsukanto Extract
Yuji KASAHARA ; Yutaka KOBAYASHI ; Atsushi CHINO ; Nobuyasu SEKIYA ; Takao NAMIKI ; Kenji OHNO ; Masaki RAIMURA ; Sumire HASHIMOTO ; Keiko OGAWA ; Hirokuni OKUMI ; Yumiko KIMATA ; Yoshiro HIRASAKI ; Toshiaki KITA ; Katsutoshi TERASAWA
Kampo Medicine 2009;60(5):519-525
We report six cases with honton disease successfully treated with a combination of goshuyuto extract and ryokeijutsukanto extract. Five of the cases were diagnosed as panic disorder, and the remaining case as generalized anxiety disorder. All six cases complained of palpitation, nausea, dizziness, headache and anxiety attacks. We diagnosed them as a hontonto (Zhouhou fang) indication. Their various complaints disappeared after combination therapy with those extracts. Furthermore, efficacy of the combination therapy was proven to be equal to hontonto. These cases suggest that the combination therapy with goshuyuto extract and ryokeijutsukanto extract is useful in place of hontonto.
8.Four Cases of Chronic Cough Successfully Treated with Boiogitokamao
Keiko OGAWA ; Nobuyasu SEKIYA ; Yuji KASAHARA ; Atsushi CHINO ; Masaki RAIMURA ; Yumiko KIMATA ; Hirokuni OKUMI ; Kenji OHNO ; Takao NAMIKI ; Tetsuo AKIBA ; Katsutoshi TERASAWA
Kampo Medicine 2010;61(3):337-344
Boiogito is mentioned in Synopsis of the Golden Chamber, in which it is written to add ephedra herb for patients with cough at the end of the chapter. We experienced 4 chronic cough cases of wind-wetness syndrome or edema caused by pathogenic Wind successfully treated with boiogitokamao. Subjective symptoms such as heaviness when moving, heavy sweating, and body chills, as well as objective findings such as pallor, and a weak pulse in the most distal region of the right wrist were common in these patients. Moreover, not only cough, but also accompanying symptoms such as obesity, dysmenorrhea, and eczema were improved. Observation of these four cases suggests that boiogitokamao can be effective for the treatment of the patients with chronic cough due to wind-wetness syndrome / edema caused by the pathogenic Wind.
9.Six Cases with 'Honton' Disease Successfully Treated with Combination of Goshuyuto Extract and Ryokeijutsukanto Extract
Yuji KASAHARA ; Yutaka KOBAYASHI ; Atsushi CHINO ; Nobuyasu SEKIYA ; Takao NAMIKI ; Kenji OHNO ; Masaki RAIMURA ; Sumire HASHIMOTO ; Keiko OGAWA ; Hirokuni OKUMI ; Yumiko KIMATA ; Yoshiro HIRASAKI ; Toshiaki KITA ; Katsutoshi TERASAWA
Kampo Medicine 2009;60(5):519-525
We report six cases with honton disease successfully treated with a combination of goshuyuto extract and ryokeijutsukanto extract. Five of the cases were diagnosed as panic disorder, and the remaining case as generalized anxiety disorder. All six cases complained of palpitation, nausea, dizziness, headache and anxiety attacks. We diagnosed them as a hontonto (Zhouhou fang) indication. Their various complaints disappeared after combination therapy with those extracts. Furthermore, efficacy of the combination therapy was proven to be equal to hontonto. These cases suggest that the combination therapy with goshuyuto extract and ryokeijutsukanto extract is useful in place of hontonto.
10.Efficacy of Kampo Medicine for Migraine in Children and Childhood Periodic Syndromes
Masaki RAIMURA ; Takao NAMIKI ; Nobuyasu SEKIYA ; Yuji KASAHARA ; Atsushi CHINO ; Yoshiro HIRASAKI ; Keiko OGAWA ; Hirokuni OKUMI ; Hideki OKAMOTO ; Yumiko KIMATA ; Keigo UEDA ; Takeshi OUJI ; Kenji OHNO ; Satoshi YAMAMOTO ; Tetsuo AKIBA ; Katsutoshi TERASAWA
Kampo Medicine 2011;62(4):574-583
In the Guideline for treatment of chronic headache published by Japanese Headache Society, Ibuprofen and Acetaminophen are proposed for the acute treatment of migraine in children. But prophylactic treatment of pediatric migraine is not established. We report the efficacy of Kampo medicine for preventing migraine in children and childhood periodic syndromes. We use a variety of Kampo medicine for 9 pediatric migraine and periodic syndromes patients from 8 to 15 years old. All 9 patients improve their headache and associated symptoms including abdominal pain, vertigo, nausea and vomiting. After treatment the mean average of Headache Impact Test-6 (HIT-6) improve from 63.66 points to 45.77 points. Kampo medicines is effective for migraine in children and childhood periodic syndromes.