1.Humanity spirit construction in medical education
Chinese Medical Ethics 1994;0(05):-
Traditional medical education has made enormous contribution for human health care and medical work for a long time. Since entering new century, the structure of order in medical and health work is confronted with severe challenges. Traditional medical education is severiously deficient in educational theory,humanism in guiding principle and practice and environment.These phenomena are, we think, the inevidable reflection of the inner conflicts between traditional Chinese medicine and Western medicine, the consequences resulting mainly from the separation of science and technology rom humanism in the technological era,and the biproducts from the unfavourable influence in the couse of marketingation. The outlet which changes the current situation lies in probing the medical educational pattern in the new century, doing the construction that the humane spirit of the medical education dimension well.
2.Genetic modification of bone marrow stem cells in treatment of hind limb ischemia
International Journal of Surgery 2009;36(8):538-541
With the development of gene technology,it is gradually possible and much better for genetic modification of bone marrow stem cells in treatment of hindlimb ischemia. Gene modification of cells prior to their transplantation, especially stem cells, enhances their survival and increases their function in cell therapy. But this treatment is only used for the experimental stage. Here, we review the current uses of gene-modified bone marrow stem cells in vascular disease.
3.Philosophy,Objectives and Methods on Ideological and Moral Construction for Medical Students
Chinese Medical Ethics 1995;0(03):-
By analyzing the status quo of moral construction of current Chinese medical students,the authors make an in-depth analysis and accurate grasp of human nature,establish a scientific concept of morality education,and clarify the objective which aims to develop students into real "socialized individuals" with mental health,personal integrity and all-round development.Four moral methods including vertical process,horizontal extension,virtual network and class building are created to promote the ideological and moral construction for medical students.
4.The influence of injection rate and time resolution on dynamic contrast-enhanced MR imaging of glioma
Journal of Practical Radiology 2016;(2):292-294,304
Objective To explore the influence of contrast agent injection rate and sequence time resolution on the dynamic contrast-enhanced MR iamging of brain glioma.Methods Fifty eight cases with suspected cerebral glioma were scanned on a Verio 3.0T MRI with the regular head sequences and DCE sequences.All the cases were divided into two groups.There were 41 cases in the regular group in which the injection rate was 3 mL/s and the time resolution was above 5.36 s.Another 1 7 cases were in the optimal group in which the injection rate was 4 mL/s and the time resolution was about 4 s.The DCE images of two groups were Postprocessed by the Tofts model analysis.The curve shape of AIF were evaluated and divided in to the excellent or the secondary level.Chi-square test was used to compare the results of two groups.Results The curve shape of optimal group was much better than that of regular group(P<0.05).Conclusion Speeding up the injection rate and the time resolution of DCE sequences would improve the image quality of DCE MRI of glioma.
5.N-methyl-D-aspartate Receptor, Cerebral Ischemia and Exercise (review)
Chinese Journal of Rehabilitation Theory and Practice 2012;18(3):247-249
N-methyl-D-aspartate (NMDA) receptors are a group of ionotropic glutamate receptors, which are in close contact with the synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD) in the cerebral cortex or the hippocampus. This article reviewed the recent development in this field.
6.Characteristic of Electrocardiogram for Female Patients with Apical Ballooning Syndrome
Chinese Journal of Rehabilitation Theory and Practice 2014;(7):690-692
Objective To analyze the electrocardiogram (ECG) characteristics of apical ballooning syndrome (ABS) in female patients in China. Methods 50 female cases of ABS patients from medical periodicals in China were analyzed. Results 50 patients were in sinus rhythm, 98% patients were abnormal in ECG. ST segment elevated in 85.7% of them, ranged 0.1-0.8 mV, and came down in 30 min-2 weeks. T wave inversion was found in 42% of them, 24% with pathological Q wave, which disappeared in 6 hours-1 month. 28% showed QT interval prolongated, 38% complicated with arrhythmia. Conclusion The abnormal ECG is common in female patients with ABS, which is transient and reversible.
7.Advances in Research on miR-21 and Breast Cancer.
He ZHANG ; Yulong ZHANG ; Linglin ZOU
Journal of Biomedical Engineering 2015;32(3):712-716
Breast cancer is a malignant tumor from normal breast epithelial. In recent years, many literature reports sought to determine the expression of predicted target genes of microRNA and their potential function, pathways and networks, which are involved in the tumorigenesis, metastasis and prognosis of breast cancer. The miR-21 has recently been found to be highly expressed in solid tumors than normal tissue, and it has exposed some layers of gene expression regulation that becomes a hot topic of breast cancer. This paper briefly reviews advances in research on miR-21 in breast cancer.
Breast Neoplasms
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Female
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Humans
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MicroRNAs
8.The functions of GPⅠa/Ⅱa and GPⅣin platelet adhesion to collagen
Zhuo ZHANG ; Yulong CONG ; Zhiguang TU
Chinese Journal of Clinical Laboratory Science 2006;0(03):-
Objective To study the functions of GPⅠa/Ⅱa and GPⅣduring the course of platelet adhesion to collagen. Methods Reaction system which contains anti-GPⅠa/Ⅱa antibody ,anti-GPⅣantibody or no blocking antibody was analyzed by flow cytomety. PE labeled anti-CD42b antibody was used to select platelet and fluorescence intension of fluorescein isothiocyanate ( FITC) was detected during the course of platelet adhesion to FITC-labeled collagen. Results The antibody against GPⅠa/Ⅱa inhibited platelet adhesion to collagen, especially to activated platelet(P 0. 05 ). Conclusion GPⅠa/Ⅱa plays an important roles in platelet adhesion to collagen. Blocking GPⅠa/Ⅱa may decrease the adhesion. GPⅣmay be helpful for acceleration of platelet adhesion to collagen at early stage.
9.Function of GPⅠa/Ⅱa in the platelet-collagen interactions
Zhuo ZHANG ; Yulong CONG ; Zhiguang TU
Chinese Journal of Laboratory Medicine 2001;0(05):-
Objective To investigate the function of GPⅠa/Ⅱa in the platelet-collage adhesion and the platelet granules release induced by collagen. Methods With the flow cytometry, in either presence or absence of the anti-GPⅠa/Ⅱa antibody: (1) PE-labeled anti-CD42b antibody was used for selecting platelet and FITC fluorescence intension was detected during the course of platelet adhered to FITC-labeled collagen. (2) PerCP-labeled anti-CD61 antibody was used for selecting platelet and detecting CD62P with PE-labeled CD62P antibody during platelet granule release induced by collagen. Results Anti-GPⅠa/Ⅱa antibody inhibited the platelet-collagen adhesion, especially the activated platelet-collagen adhesion (P0.05). Conclusion GPⅠa/Ⅱa plays an important role in platelet-collagen adhesion. Blocking GPⅠa/Ⅱa can decrease the platelet-collagen adhesion, but has no effects on platelet granule release reaction.
10.Changes of myoepithelial cells during regeneration of parotid gland.
Yulong MAO ; Weiwei ZHANG ; Jinhua ZUO
West China Journal of Stomatology 2014;32(5):446-449
OBJECTIVETo investigate the changes on the number and distribution of myoepithelial cells (MECs) during parotid gland regeneration.
METHODSA total of 54 Wistar rats were divided into eight experimental groups and one normal control group, with six rats in each group. The right parotid ducts of the rats in the experimental groups were ligated for 14 days and then reopened. The parotid tissue specimens were harvested at days 0, 1, 3, 5, 7, 10, 14, and 21. The histological changes of the regenerating gland were examined using hematoxylin-eosin staining. Immunohistochemical labeling was also performed to investigate the changes in the number and distribution of MECs at different time points of parotid regeneration. Both the histological and immunohistochemical changes observed in the experimental groups were compared with those in the normal control group.
RESULTSThe parotid gland showed marked atrophy 14 days after ligation. Most acinar cells disap- peared, but the number of duct-like structures obviously increased. MECs apparently increased in number and were mainly located at the periphery of the duct-like structures. Three days after duct reopening, the number of acinar cells significantly increased and the duct-like structures significantly reduced. Meanwhile, MECs also decreased in number and were mainly located at the periphery of the newly formed acini and duct-like structures. The number of MECs noticeably decreased 3 and 5 days after duct reopening. At 14 days after duct reopening, the glandular structures and the number and distribution of MECs returned to normal compared with those in the normal control group.
CONCLUSIONThe number and distribution of MECs returned to normal condition after parotid gland atrophy. Parotid regeneration mainly occurred within 5 days after duct reopening.
Animals ; Atrophy ; Epithelial Cells ; Ligation ; Parotid Gland ; Rats ; Rats, Wistar ; Regeneration ; Salivary Ducts