Traditional medical education has made enormous contribution for human health care and medical work for a long time. Since entering new century, the structure of order in medical and health work is confronted with severe challenges. Traditional medical education is severiously deficient in educational theory,humanism in guiding principle and practice and environment.These phenomena are, we think, the inevidable reflection of the inner conflicts between traditional Chinese medicine and Western medicine, the consequences resulting mainly from the separation of science and technology rom humanism in the technological era,and the biproducts from the unfavourable influence in the couse of marketingation. The outlet which changes the current situation lies in probing the medical educational pattern in the new century, doing the construction that the humane spirit of the medical education dimension well.

By analyzing the status quo of moral construction of current Chinese medical students,the authors make an in-depth analysis and accurate grasp of human nature,establish a scientific concept of morality education,and clarify the objective which aims to develop students into real "socialized individuals" with mental health,personal integrity and all-round development.Four moral methods including vertical process,horizontal extension,virtual network and class building are created to promote the ideological and moral construction for medical students.

With the development of gene technology,it is gradually possible and much better for genetic modification of bone marrow stem cells in treatment of hindlimb ischemia. Gene modification of cells prior to their transplantation, especially stem cells, enhances their survival and increases their function in cell therapy. But this treatment is only used for the experimental stage. Here, we review the current uses of gene-modified bone marrow stem cells in vascular disease.

Objective To explore the influence of contrast agent injection rate and sequence time resolution on the dynamic contrast-enhanced MR iamging of brain glioma.Methods Fifty eight cases with suspected cerebral glioma were scanned on a Verio 3.0T MRI with the regular head sequences and DCE sequences.All the cases were divided into two groups.There were 41 cases in the regular group in which the injection rate was 3 mL/s and the time resolution was above 5.36 s.Another 1 7 cases were in the optimal group in which the injection rate was 4 mL/s and the time resolution was about 4 s.The DCE images of two groups were Postprocessed by the Tofts model analysis.The curve shape of AIF were evaluated and divided in to the excellent or the secondary level.Chi-square test was used to compare the results of two groups.Results The curve shape of optimal group was much better than that of regular group(P<0.05).Conclusion Speeding up the injection rate and the time resolution of DCE sequences would improve the image quality of DCE MRI of glioma.

N-methyl-D-aspartate (NMDA) receptors are a group of ionotropic glutamate receptors, which are in close contact with the synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD) in the cerebral cortex or the hippocampus. This article reviewed the recent development in this field.

Objective To analyze the electrocardiogram (ECG) characteristics of apical ballooning syndrome (ABS) in female patients in China. Methods 50 female cases of ABS patients from medical periodicals in China were analyzed. Results 50 patients were in sinus rhythm, 98% patients were abnormal in ECG. ST segment elevated in 85.7% of them, ranged 0.1-0.8 mV, and came down in 30 min-2 weeks. T wave inversion was found in 42% of them, 24% with pathological Q wave, which disappeared in 6 hours-1 month. 28% showed QT interval prolongated, 38% complicated with arrhythmia. Conclusion The abnormal ECG is common in female patients with ABS, which is transient and reversible.

Breast cancer is a malignant tumor from normal breast epithelial. In recent years, many literature reports sought to determine the expression of predicted target genes of microRNA and their potential function, pathways and networks, which are involved in the tumorigenesis, metastasis and prognosis of breast cancer. The miR-21 has recently been found to be highly expressed in solid tumors than normal tissue, and it has exposed some layers of gene expression regulation that becomes a hot topic of breast cancer. This paper briefly reviews advances in research on miR-21 in breast cancer.
Breast Neoplasms ; Female ; Humans ; MicroRNAs

Objective:To investigate the histological changes of parotid gland after ligation and reopening of the main duct.Meth-ods:The right parotid main duct was ligated for 14 days and then reopened,the specimen were harvested at day 0,1,3,5,7,10,14 and 21 after reopening(n=5 )respectively.By HE staining and Morphology measurement,the morphological and volume fraction changes of acinus,duct and mesenchyma were observed and measured.Results:The parotid gland atrophied significantly 14 days af-ter the duct ligation.From day 3 after duct reopening,the acinar volume fraction continued to increase,both the duct and the mesen-chymal tissue volume fraction continued to decrease significantly(P<0.05).After 14 days of duct reopening,there was no signifi-cant difference in volume fraction of acinar,duct and mesenchyma,compared with those of normal control group(P>0.05).Conclu-sion:After reopening of the ligated main duct the atrophied parotid gland is able to regenerate to be normal.

Objective To investigate the relationship of apolipoprotein E (ApoE) allelic frequency and serum lipid levels in patients with Alzheimer′s disease (AD). Methods DNA microarray was used to detect the ApoE genotypes of AD patients (n = 200) and age-matched non-demented elderly control subjects (n = 159). Serum lipid levels was measured by Immunoturbidimetric assay at the same time. We analyzed the ApoE genotype distribution and the relationship of apolipoprotein E ( ApoE ) allelic frequency and serum lipid levels . Results The ApoE ε4 allelic frequencies (25.5%) in AD group is higher than that of the control group (7.9%) (P < 0.05). The ε2 allele was associated with a higher ApoE concentration, whereas with a mediate concentration in ε3 and the lowest concentration ( P < 0 . 05 ) in ε4 . Serum concentrations of ApoE showed no significant difference between AD patients and the healthy population who were with the same genotype (P > 0.05). Conclusion The ApoE levels are negatively related to ApoE ε4 allele frequency and have no significant differences with the same genotype in AD and the control group,which suggests that lower serum ApoE levels in AD patients is caused by higher ApoE ε4 allelic frequency in AD than in healthy population.

As a kind of common autoimmune diseases,rheumatoid arthritis (RA) affected the health of human beings seriously.In the past,serological diagnosis of RA solely relied on the detection of rheumatoid factor (RF),but its specificity was not satisfactory.Lately,people found that anti-cyclic citrullinated peptide (CCP) antibody was a serological indicator of RA.Now,there have been a series of kits for the detection of anti-CCP antibodies to diagnose RA.The sensitivity and specificity of anti-CCP antibody detection are better than those of RF detection.This paper reviews the significance and value of anti-CCP antibody detection used for clinical diagnosis in the recent years,while systematically compares the sensitivities and specificities between several common commercial kits and methods of anti-CCP antibodies detection.