ObjectiveTo explore the proper service mode during perinatal period in obstetric de-partment through application of clinical nursing pathway theory. Methods2597 outpatient and inpatient pregnant women were randomly chosen. The experimental group (1332 cases): the clinical nursing pathway in different stages of perinatal period was designed, nurses completed their tasks according to the standard process. The control group (1265 cases): accepted the routine healthcare education and ordinary delivery method. The delivery outcome and the delivery time of the two groups were observed and recorded, satisfac-tion degree with the nursing service and nurses' mental condition before and after the application of clinical nursing pathway were also investigated. ResultsThe rate of cesarean operation of the experimental group was lower than that of the control group. The difference of total delivery time in the two groups was signifi-cant. The satisfaction degree to the nursing service improved obviously in the experimental group. The dif-ference of nurses' self- confidence, self- determination, working satisfaction, sense of competence before and after the application of clinical nursing pathway was significant. ConclusionsApplication of clinical nursing pathway in pregnant and lying-in women during perinatal period can improve the confidence of natural delivery, shorten the delivery time, reduce the cesarean operation rate, improve satisfaction degree to nurses' work, mental condition, and their general diathesis.

Objective To explore the clinical effect and safety of Shugan-Jianpi-Huayu decoction combined with entecavir for the patients with hepatic cirrhosis of hepatitis B.Methods A total of 150 patients with hepatic cirrhosis of hepatitis B visiting our hospital from Jan. 2013 to Jan. 2015 were enrolled and randomly divided into the observation group and control group, 75 in each group. The control group received entecavir, while the observation group received Shugan-Jianpi-Huayu decoction additionally. The index of liver fuction and liver fibrosis, clinical efficacy and adverse reactions were observed and compared after the treatment.Results After treatment, the AST (42.88 ± 12.57U/Lvs.56.94 ± 14.83U/L,t=6.263), ALT (41.10 ± 10.61U/L vs.53.12 ± 16.78U/L,t=5.243), TBIL (20.15 ± 9.76μmol/Lvs.28.35 ± 12.20μmol/L, t=4.545), PC Ⅲ (103.65 ± 22.84μg/Lvs. 162.44 ± 38.90μg/L,t=11.287),Ⅳ-C (106.72 ± 23.41μg/Lvs.152.94 ± 30.01μg/L, t=10.518), LN (92.75 ± 25.32μg/Lvs.156.64 ± 38.79μg/L,t=11.945), HA (105.58 ± 18.07μg/L vs.159.74 ± 35.50μg/L,t=11.775) of the observation group were significantly better than those of the control group (allP<0.05). The total efficacy rate of the observation group were 85.33% (64/75), which were significantly higher than 64.00% (48/75) of control group (χ2=9.023,P=0.003).Conclusions The Shugan-Jianpi-Huayu decoction combined with entecavir showed efficacy and safey for the patients with hepatic cirrhosis of hepatitis B.

Objective To investigate the relationship of the killer cell immunoglobulin-like receptor (KIR) gene polymorphism with Hashimoto′s thyroiditis(HT). Methods One hundred HT patients and 260 randomly matched healthy controls were enrolled to detect the KIR genotype. The genomic DNA were extracted, and 15 selected KIR genes, KIR2DL1-5, KIR3DL1-3, KIR2DS1-5, KIR3DS1 and pseudogene KIR2DP1, were determined by a polymerase chain reaction using sequence-specific primers (PCR-SSP). Results The frequency of KIR2DL5 gene was significantly lower of the patient group than that of the control group (0.200 vs 0.312, RR=0.64, P<0.01). Conclusion There may be an association between pathogenesis of HT and KIR2DL5 gene.