1.The Effect of the Kampo-Formula without Shakuyaku on the Palpitation at Rest Due to Imbalance of Ki-distribution.
Takahiro SHINTANI ; Atsushi CHINO ; Yuko Kawashima ; Noriko NAGAYAMA ; Yutaka TAKAYA ; Katsutoshi TERASAWA
Kampo Medicine 2002;53(3):223-228
We treated five patients with palpitation at rest due to imbalance of Ki-distribution, a concept of traditional Chinese medicine in which there is abnormal upward flowing of “Ki, ” who showed rapid improvement after Shakuyaku was excluded from their original regimen or after initiation of treatment with Shakuyaku-free regimens. All these patients shared in common two findings before the initiation of the Shakuyaku-free treatment: first, the absence of strain of the rectus abdominas muscle in the whole abdomen between the hypochondrium and the upper margin of the pubic bones, and secondly, the presence of abdominal pulsation diagnosed as pericardiac, infra-umbilical or sub-umbilical pulsation. We also treated patients who developed palpitation at rest only after Shakuyaku-free regimens were replaced with regimens including Shakuyaku. These findings suggest that there may be many patients in whom Shakuyaku-free regimens may improve palpitation when they have an imbalance of Ki-distribution as an underlying condition.
2.Safety of fucoidan from Gagome kombu (Kjellmaniella crassifolia) in healthy adult volunteers
Hiromu OHNOGI ; Yusuke NAKADE ; Yuko TAKIMOTO ; Akiko SEKIYA ; Takuya KAWASHIMA ; Andrew SCHNEIDER ; Takanari ARAI ; Kazuo UEBABA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2011;8(2):45-53
Object: Fucoidan is a sulfated polysaccharide in brown marine algae. Gagome kombu (Kjellmaniella crassifolia) is a Japanese edible seaweed and contains fucoidan abundantly. Recently, it was reported that fucoidan from Gagome kombu (GKF) had anti-tumor, immune-enhancing and anti-coagulant activities. In this study, we conducted a safety of GFK on the healthy adult.
Methods: Thirty-two healthy volunteers were randomly divided into 4 groups and administered a standard volume and three times volume of two kinds of test drinks containing GKF for 4 weeks.
Result: No abnormal changes were observed after test drinks ingestion on blood chemistry, urinalysis, hematological data and blood pressure. No severe adverse events related to test drinks were observed. Moreover, increase of Th1 cells was observed in immunological analysis.
Conclusion: This study suggests that GKF is safe in healthy adults.