Hematological values were studied in cases of a thorough physical examination, chronic hepatitis and alcoholic liver injury. Cases of a thorough physical examination were a control group. Only thrombocyte count was decreased in cases of chronic hepatitis as compared with a control group. On the other hand a red blood cell count, MCV, MCH and neutrophils were changed significantly in cases of alcoholic liver injury. A red blood cell count was decreased, but MCV, MCH and neutrophils were increased. Correlation between MCV and each item of liver function tests was studied. No significantly correlated item was found in a control group and cases of chronic hepatitis, but GOT/GPT, LDH and CHE were significantly correlated in cases of alcoholic liver injury.

We gathered information of both drinking and smoking habits by questionnaires. Objects of our study were 246 male cases around Yanai City. These cases were divided into six groups. The 1st: less than 20 grams of ethyl alcohol daily and less than 10 cigarettes daily (56 cases). The 2nd: 20 grams and less than 10 cigarettes (39 cases). The 3rd: more than 40 grams daily and less than 10 cigarettes (36 cases). The 4th: less than 20 grams and more than 10 cigarettes (36 cases). The 5th: 20 grams and more than 10 cigarettes (23 cases). The 6th: more than 40 grams daily and more than 10 cigarettes (56 cases).
The 1st group was a control group, and was compared among the 4th, 5th and 6th group. Consequently obesity index and serum total protein level were decreased signifiacantly in the 5th and the 6th group. There were no significantly different items in the 4th group. It was thought that both drinking and smoking habits suppressed a nutritional state of a whole body.

The HCV antibody positive rates of blood donors were studied in Yamaguchi Prefecture. C100-3 antibody was examined by the method of the 1st generation. The subjects were 146, 792 people who donated blood from Nov. 1989 to Dec. 1990. The average positive rate was 1.01% in Yamaguchi Prefecture. The positive rates of more than 3% were registered in four towns. In one town out of these four, the average positive rate was 22.0% It was extremely higher than the other three towns. Further study will be required to elucidate such regional differences in the HCV positive rate in the prefecture.

The ratio of men to women was studied in 331 patients hospitalized into our department for the past three years for various liver diseases. Two factors seemed to affect the sex difference in the morbidity of liver disease. One was a history of drinking, the other a positive ratio of HBs antigen. So, heavy drinkers and HBs antigen positive cases were excluded from the patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma, and the male/female ratio was studied again. The ratio of men to women in the patients with liver cirrhosis was 1.3: 1, 4. 1: 1 in the patients with hepatocellular carcinoma and 2.0: 1 in the patients with chronic hepatitis. The male ratio was strikingly high in the case of hepatocellular carcinoma. It is thought that liver cirrhosis is a cause of hepatocellular carcinoma. And then differences in the results of liver function tests between men and women were studied in the patients with liver cirrhosis. However, no remarkable difference was found between men and women.

We gathered information of both drinking and smoking habits by questionnairing. The subjects of our study were 116 men around Yanai City. They were divided into five groups. 1st: neither drinking nor smoking habits (23 cases). 2nd: 20 or 40 grams of ethyl alcohol daily and no smoking habit (31 cases). 3rd: more than 40 grams daily and more than 10 cigarettes (32 cases). 4th: 20 grams daily and more than 10 cigarettes (16 cases). 5th: no drinking habit and more than 10 cigarettes daily (14 cases).
The 1st group was a control group, and was compared with the 2nd, 3rd 4th and 5th groups. Consequently both systolic and diastolic blood pressure levels rose significantly only in the 3rd group. Only systolic blood pressure level rose significantly in the 4th group. And so it was suggested that both drinking and smoking habits raised both systolic and diastolic blood pressure levels.

The subjects are 223 women who participated in a mass medical examination. Their ages are between 40 and 79 years. We divided them into four age groups, and studied how aging and obesity influenced their physical health. The results showed the obesity index and serum total protein level were significantly low in the 70-to-79 age group. The serum total cholesterol level was significantly high in the age group between 40 and 50, and it was thought that the elevated cholesterol levels were due to menopause. Thus in females this suggests that a great physical change occurs first in the age group between 40 and 50, and second in the age group between 60 and 70.
Using 165 female cases whose ages were between 40 and 69 years were subdivided into four obesity index groups, we studied how the obesity influenced their physical health. The results showed that the problems include the elevation of diastolic blood pressure levels and serum uric acid levels.

To find a link between lifestyle and arteriosclerosis, the serum lipid values were studied in those who had entered our hospital for a thorough physical examination. The subjects were 136 men and 31 women. They were divided into six groups. 1st: neither drinking nor smoking habits (24 cases). 2nd: 20 or 40 grams of ethyl alcohol daily and no smoking habit (45 cases). 3rd: more than 40 grams daily and more than 10 cigarettes (21 cases). 4th: 20 grams daily and more than 10 cigarettes (25 cases). 5th: no drinking habit and more than 10 cigarettes daily (21 cases). 6th: women who had neither drinking nor smoking habits (31 cases).
The 2nd group was a control group, and was compared with each group. It was found that only TG values were significantly high in the 3rd group. HDL-C values were significantly low in the 5th group. There were no significant differences in the 1st and 4th groups. T-CHO and LDL-C values were significantly high in the 6th group. These facts suggest that it is difficult to correlate both drinking and smoking habits with the incidence of arteriosclerosis. And perhaps it is the same in women, because LDL-C values were high in women, but at the same time HDL-C values were high.