Abstruct
  Effective method for the management of information on adverse reactions is not uniformly in place, due to differences among medical facilities.  We have been developing a strategy for the effective management of adverse drug reactions on the transition of clinical records from paper to electronic media.
  We have taken a forward-thinking approach after 4 years identifying each year’s main target, predicted problems and how to address them in every year.  The targets for the four 1-year periods were: enabling the collection and analysis of information on adverse reactions from paper-based clinical records, standardized handling of adverse reactions in situations where paper records are still in use, transition of adverse reaction information to electronic records, and sharing of information on adverse reactions where electronic records are in use.  The Committee on Adverse Events conducted analysis of information on adverse reactions which were collected regardless of seriousness, disseminated useful information to all medical staff, and determined the degree to which each period target was achieved.
  The transition to electronic form of information on adverse reactions achieved 0% success within the target period.  Establishing effective management of adverse reactions will require 5 years, with as yet unresolved issues remaining.  During 5 years, 767 incidents of adverse reactions were reported, 73.1% by physicians, the proportion by nurses increasing from 6.7% to 22.3%.
  Strategic approach will help to establish a effective management of adverse reactions, which contribute to the adequate use of drugs and safety management of patients.

The aim of the present study was to evaluate the relation between basal metabolic rate (BMR) and body composition in 29 Japanese elite male athletes (age 25.6±3.7y, height 175.6±7.0cm, body weight 74.7±12.8kg, fat-free mass (FFM) 64.9±9.3kg). The subjects were classified into three groups according to their FFM. There was a significant difference in BMR/FFM between S-group (less than 0.5SD of average FFM) and L-group (more than 0.5SD). The parcentage of RM to body weight in S-group was significantly higher than in L-group. In conclusion, high basal metabolic rate/fat-free mass ratio in Japanese elite male athletes can be attributed to body composition.