1.Acute encephalopathy with callosal, subcortical and thalamic lesions
uko Nakano ; Yukifumi Monden ; Masashi Mizuguchi ; Masako Nagashima ; Yasunori Koike ; Yuji Gunji ; Naoto Takahashi ; Hideo Sugie ; MarikoY. Momoi ; Takanori Yamagata
Neurology Asia 2015;20(1):85-89
Acute encephalopathy is classified into multiple syndromes, such as acute encephalopathy with biphasic
seizures and late reduced diffusion (AESD), clinically mild encephalitis/encephalopathy with a reversible
splenial lesion (MERS) and acute necrotizing encephalopathy (ANE), characterized radiologically
by lesions in the cerebral subcortical white matter, splenium of the corpus callosum and bilateral
thalami, respectively. We described a previously healthy 8-year-old boy who had febrile and biphasic
seizures, and encephalopathy. MRI showed abnormal signal intensity in the corpus callosum on day
2 and cerebral subcortical white matter and bilateral thalamic lesions on day 8. This is the first case
of acute encephalopathy in which callosal, subcortical and thalamic lesions co-existed. The clinical
course of this case was typical for AESD, atypical for MERS, and different from that of ANE.
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