The drug resistance of leukemia cell is the main point to cause failed chemical therapy,reduce relieving rate and influence the effect of chemical therapy on leukemia,which is an urgent clinical problem needing to be settled presently.The article sums up the researches on this subject from our traditional medicine.

Liposarcoma is the most common soft tissue sarcoma.Liposarcoma is widely diverse in the clinical,pathological,and molecular characteristics.Surgery is still the mainstay of liposarcoma therapy and the only cure way.With the development of molecular biology,as well as the discovery of molecular pathways,oncogenes and anti-oncogenes,it is possible to treat liposarcoma with targeted drugs.

Objective To assess the population pharmacokinetic parameters for propofol for Chinese surgical patients using a nonlinear mixed- effect model (NONMEN) program and qualitatively analyze the effects of gender, age and body weight.Methods Seventy-six ASA I - II patients(37 male,39 female) ,aged 17-77 years weighing 39-86 kg. Undergoing elective surgery were studied. The patients were premedicated with intramuscular sodium luminal 0.1 g and scopolamine 0.3 mg. Radial artery was cannulated for blood pressure monitoring and blood sampling. BIS, AEPindex, EGG, BP, PET CO2 and SpO2 were continuously monitored during operation. Anesthesia was induced and maintained with propofol and fentanyl. A loading dose of fentanyl 3 ?g? kg-1 was given iv followed by infusion at 2 ?g ? kg -1? h-1 until 30 min before the end of surgery. Propofol 1 -2.5 mg ?kg -1 was given iv over 0.5-4 min followed by infusion at 3-8 mg ? kg-1? h-1 until the end of surgery. When the patient was unconscious intubation was facilitated with vecuronium 0.1 mg? kg-1 . Blood samples were obtained before propofol and 2-120 min during propofol infusion and 2-600 min after discontinuation of propofol infusion for determination of blood propofol concentration. 1 439 blood samples were analyzed using NONMEM program. Interindividual and intraindividual variability was estimated for clearance and volume of distribution. The effects of age, body weight and gender were investigated. Results The pharmacokinetics of propofol in Chinese patients was best described by a three-compartment pharmacokinetic model . Body weight was found to be a significant factor affecting the two inter-compartmental clearances and the volume of the central compartment. The shallow and deep peripheral compartments remained constant for all individuals. For a 60 kg adult these parameters were estimated to be 1.56 L?min-1, 0.737 L?min-1 , 0.360L?min-1 ,12.1 L,43 L,213 L,respectively. For elderly patients, the clearances and volume of central compartment decreased with increasing age. Conclusions The pharmacokinetics of propofol in Chinese patients can be well described by a standard three-compartment pharmacokinetic model. Age and body weight can affect the parameters of the pharmacokinetic model. Pharmacokinetics adjusted to the individual patient should improve the precision of TCI system.

Objective: To explore the effect of social support in increasing the quality of life of renal transplant patients by investigating social support and quality of life of renal transplant patients in our hospital.Methods: The patients after renal transplantation more than 3 months were questioned randomly in clinic using the rating scales of SSRS and WHOQOL ~BREF.Results: It showed high social support in patients after renal transplantation,but there was dangerous of low social support in young female.The score of quality of life and physiological domain was lower than routine model.There were not significant differences in the psychological,social and surrounding domains of renal transplant patients compared with the routine model.There was a significantly positive relationship between social support and quality of life of renal transplant patients(P

ObjectiveExplore the pathogeny of cell immunity of severe aplastic anemia(SAA),also appraise the effect and prognosis value of T cell subset change in the treatment of SAA.MethodTake normal persons as control,combine CD_3,CD_4,CD_8 with human being peripheral blood monocytes,analyse with flow cell method the cells of CD~+_3,CD~+_4,CD~+_8 in monocyte and CD~+_4/CD~+_8.Compare and analyse T cell subset in 3 groups before and after treatment.ResultCompared with control,there’s obvious meaningful difference in T lymphocytesCD~+_3 and CD~+_8,and CD~+_4/CD~+_8(P

Objective To observe the therapeutic effect of Jingganquzhi decoction(JQ,净肝祛脂汤) in treating non-alcoholic fatty liver.Methods Eighty patients with non-alcoholic fatty liver were randomly divided into treatment group to receive JQ and control group to receive Dongbaogantai(DG,东宝肝泰) orally for 3 months.The changes of liver function,blood lipids,B ultrasonic examination were observed.Results After the treatment,the liver function criteria: alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),?-glutamyltransferase(?-GGT) and blood lipids of triglycerides(TG),total cholesterol(TC) were lower than those before the treatment,while the high-density lipoprotein cholesterol(HDL-C) was higher than that before the treatment in both groups(all P

HERG/IKr plays an important role in repolarization of cardiac action potential. In pathological condition such as cardiac ischemia, congestive heart failure and myocardial hypertrophy, the density and kinetic properties of HERG/IKr will change. This review is about modulation of HERG/IKr in pathological condition and effect of traditional chinese medicine on HERG/IKr.

The understanding and treatment of Traditional Chinese Medicine(TCM) on chronic idiopathic thrombocytopenic purpura(CITP) is prosperous,while no conclusion is yielded.By digging out documentation and summarizing clinical experience,"Qi and Yin Discrimination","Viscera Discrimination"and "Meridians Discrimination"are concluded to formulate the idea that the treatment of CIPT should bebased on Qi and Yin in this article,which aims at identifying the understanding of TCM on CITP,and then guiding clinical practice to improve therapeutic effect.

The medication characteristics of doctor ZHENG Chong-guang in Qing Dynasty was studied from prescription metrology range index,including properties,tastes,channel tropism and function index.It was found that his clinic prescription practice was different from other doctors in Jiangzhe province which originated from his territory character,the territory character of Xin'an school was disclosed,it was suggested that prescription metrology range index was an valuable impersonal index for doctor's territory character.

Objective to evaluate the clinical efficacy and safety of ADSCs infusion in patients with type 2 diabetes mellitus(t2DM). Methods Autologous ADSCs were cultured and identified. totally 48 cases of type 2 diabetes patients were divided into two groups:24 cases in A group re-ceived ADSCs and conventional treatment,while the other 24 cases in B group received conventional treatment. With 15 months′follow-up,FPG,2h-PGh,HbA1c,FC-P,AUCC,insulin medication changes and security on post-treatment 3,6,12 and 15 months were calculated. Results the AD-SCs which cultured met the clinical application of standards. FPG,2h-PGh and HbA1c in both groups were significantly decreased,and the values in A group were more impressive than B. there were significant improvement in FC-P,AUCC and insulin of A group compared with B group. there was not treatment related adverse events. Conclusion the clinical data demonstrate that the treatment with ADSCs can improve metabolic control and beta cell function in patients with t2DM. Moreover,the safety of the treatment method was considerable.