Objective: To investigate relationship between cognitive function and quality of life of elderly living in beadhouses Method: 251 persons aged 55 or above living in three beadhouse for at least 1 year were assessed with GQOLI-74 (generic quality of life inventory-74), SAS (self-rating anxiety scale), CESD (center for epidemiologic studies depression scale), MMSE (mini mental state examination) and ADL (activity of daily living) Result: The elderly with low MMSE scores had lower scores in GQOLI-74 than that normal in MMSE assessment The quality of life correlated with depression and cognitive function Those in marriage had better life quality than those widowed Conclusion: Cognitive function is an important factor on quality of life of elderly living in beadhouses

ObjectiveTo construct expressing vector of microRNA with molecular cloning methods which target CD4 and electroporating the vector to the MT4 cell to determine its effect to CD4 expression.MethodsPredict a microRNA can target CD4.Linking the pre-mir-181a PCR products to T vector,then cloning into the pEGFP-N1 vector after enzyme digestion.To test the integrity through the colony PCR and sequencing analysis.Electroporating the vector to MT4 cell,using FACS to test the CD4 expression.ResultsHsa-mir-181a is able to target CD4.The sequence of the construct was correct.The hsa-mir-181a is stable expressing in MT4 after electroporating with the vector and MT4 cell CD4 was down-regulated.ConclusionThe construct can be stable expressing hsa-mir-181a in MT4 cell and down-regulating the CD4 expressing.This method can be utilized as a novel intervention to the HIV fusion,it shows potential as a gene therapy tool in vitro.

Objective To analyze youth talents' scientific research projects in research oriented hospital for recent five years,provide scientific basis for hospitals to strengthen the youth talents' capacity building of research innovation.Methods Identify those youth talents who have been funded in the First Affiliated Hospital of Xinjiang Medical University,and statistically analyze the demographic information,granted scientific research projects and hospital funding situations.Results There are 140 young talents who have got scientific research projects from 2011 to 2015 in the hospital.The national project number and the trend of approval rate has no obvious change;the provincial level project number and approval rate showed a trend of a significant increase in the last two years;Setting up the hospital fund promoted the youth talents' scientific research ability,but there are still spaces for further improvement in the funding field and founded group.Conclusions There has been a group of youth talents to stand out from the crowd during the construction and the development of the researchoriented hospital,but youth talents remains scarce for the national key projects and talent projects,and that will put forward new requirements for the hospital in the future to strengthen the youth talents' capacity building of research innovation,which needs to gradually establish a suitable cultivation mode and mechanism for youth talents' growth.

Objective To understand the current situation and the main influencing factors of hospital staffs' scientific research work in a affiliated hospital of Xinjiang,so as to provide the basis for improving awareness and level of scientific research of hospital staffs.Methods Survey using stratified random sampling method,using self-questionnaire research capacity factors questionnaire, to investigate the status of project leaders' research capacity in a affiliated hospital of Xinjiang.Using frequencies and relative number described ability to research,using x2 to compare research level among the various metrics.Scientific research levels' multivariate analysis using Ordinal Logistic Regression Analysis.Results regarding of scientific research,low level of 14 people,accounting for 4.9％,the middle level of 158 people,accounting for 55％,a high level of 115 people,accounting for 40.1％.Univariate analysis showed that age,length of service,education level,job title,whether master instructor it is,the research team,the situation of foreign training and learning opportunities,foreign academic session (times),support from leadership and family,non-working time for research,the total research funding (ten thousands yuan),discipline level have impact on the level of scientific research work.Ordinal Logistic regression analysis showed that age,length of service,educational level,whether master instructor it is,the total research funding (ten thousands yuan),discipline level are the main factors on level of scientific research work.Conclusions The scientific research level needs to be further improved,the level of scientific research is affected by many factors.

Objective To learn the training effect and main influencing factors for residents′ standardized training in Xinjiang.Methods In the convenience sampling principle, 220 trainees subject to training at 10 training centers in Xinjiang were surveyed with questionnaire.Measurement indicators were described with frequencies and relative number, and x2 test was used to compare overall training outcomes among individual measurement indicators.Results Significant gaps were found among the respondents in terms of training outcomes.A comparison of six level-1 indicators and 25 level-2 indicators found that the respondents gave average comment to teaching and research training.Logistic regression analysis identified education (x2=7.575,P=0.006) and hospital (employer) or school (x2=10.770,P=0.001) as the main influencing factors for training outcomes.Conclusions The standardized training of residents in Xinjiang calls for greater improvement, namely enhanced leadership and powerful assurance mechanism, scientific planning, appraisal regulations and motivation mechanism, as well as encouraging academic environment.

Objective To construct evaluation system of residents standardization training's effect in Xinjiang. Methods According to the principles of combinations of comprehensiveness and direction, sci-entificity and operability, initial questionnaire regarding for residents' attitude, knowledge and ability was modified to form the final questionnaire through the first round of the survey using literature research and expert interviews. Internal consistency check was carried out for all valid questionnaires by SPSS 18.0, the reliability coefficient was calculated by Alpha test and the analytic hierarchy process was used to determine the indicators' weights of evaluation system of residents standardization training's effect in Xinjiang. Results The cronbach coefficient of the questionnaire was 0.894, with a higher reliability. Evaluation system of resi-dents standardization training's effect in Xinjiang included 6 first-level indicators and 23 second-level indi-cators, and calculated their respective weight coefficients. Conclusion Evaluation system of residents stan-dardization training's effect which was constructed and was in accordance with the reality of Xinjiang was more reasonable. It is of guiding significance to comprehensively and objectively measure the training effect of trainees and to strengthen and improve residents' standardization training in Xinjiang.

Objective Though the research on the satisfaction of environment and factors influ encing the growth of the talented in medical science in Xinjiang,the author focuses on the shortcomings and reasons of current development of the talented,and provides specific suggestions and improvement for the cultivation of the talented.Methods Using Xinjiang Medical University First Affiliated Hospital as the research object,author investigates the influential factors of growth,and the satisfaction of environment though the questionnaires.Results According to the principal components analysis,the factors which influence the growth the talented in medical science are put in flowing order:political factor＞environmental factor＞education factor＞family factor.According to the data envelop ment analysis,in the satisfaction of environment of hospital technological innovation,the talented in hospital technological innovation consider that the cultivation plan,research expenses,support for scientific research,recruitment,and social welfare are at a better satisfaction rate;but the duration of academic research,income policies,selection of the talented,and the outcome of the research are at a low satisfaction rate.Conclusions Based on the current development and cultivation of the talented in the innovation of medical science,there are still many shortcomings.Hospital must continue interna tional cooperation,insist to do the cultivation of the talented and the innovation team,and complete the selection mechanisms,in order to give enough time for the scientific research,and create a good atmosphere of medical science innovation at the same time.Only when the services for the talented are well-prepared,Xinjiang medical science innovation can achieve enough support and motivation for the development of the talented.

Objective This study uses the KANO model to evaluate the satisfaction of the growth environment of medical science and technology innovation talents in Xinjiang,comprehensively understand the needs of talents for the growth environment,and propose specific countermeasures for the improvement and related direction of Xinjiang's science and technology innovation talent growth environment.Methods Science and technology innovation talents from three tertiary hospitals in Xinjiang were selected as research subject,questionnaire survey was conducted to understand their basic information,and to confirm the talents growth environment for the current attitude according to the structural KANO model questionnaire includes rules.Results The KANO model was used to determine five key indicators that have high sensitivity to the satisfaction of Xinjiang medical science and technology innovation talents.They are research funding,scientific research facilities,scientific research reward mechanism,scientific research team cooperation,and academic exchanges domestically and internationally.Conclusions According to the key influencing factors of Xinjiang medical science and technology innovation talent satisfaction,improving and optimizing the corresponding indicators can effectively improve the overall quality of the technological innovation talent growth environment and improve the satisfaction of scientific and technological talents.

Objective To determine the weights of performance appraisal indicators of autonomous regional attached re-search institute of medicine in Xinjiang .Methods The AHP analysis method was used to establish a judgment matrix ,which determined the corresponding weights of the factors ,and calculated the total weight coefficient of the indicators that constitute the performance evaluation system of autonomous regional attached research institutes of medicine .Finally ,consistency check was performed on the judgment matrix .Results The assignment of experts to each indicator was reasonable and effective ,and the comparison with each other of the relative importance of indicators was appropriate .The weight coefficients of the criteria layer respectively were 0 .09246 ,0 .20434 ,0 .17473 ,0 .23681 ,0 .29166 ,and the total weight coefficient of the indicators were calculated .A performance evaluation model of attached research institute of medicine in Xinjiang was constructed .Conclusions The performance appraisal system of autonomous regional attached research institute of medicine in Xinjiang established by the AHP analysis method had a high degree of credibility and operability ,which can be used as a reference for further strengthe-ning the management of the institutes .

Objective This paper discussed the implementation effect of medical research integrity and related code of conduct in a general hospital in xinjiang,to provide theoretical basis for the construction of medical research integrity.Methods According to the gap analysis theory,a questionnaire was designed for satisfaction with the implementation effect of medical research integrity and related code of conduct in the hospital.101 researchers in the hospital were surveyed to understand their evaluation on various aspects of the hospital's scientific research integrity construction policies and the space for improvement.Results The gap analysis showed that the hospital has a large gap in the construction of "institutional construction of scientific research integrity management " and "methods and regulations for dealing with academic misconduct",which were urgently need to be improved in the scientific research integrity construction.Conclusions The hospital should further improve the system of scientific research integrity construction,combine the characteristics of medical development and the corresponding national policy development,strengthen the innovation of scientific research management,create a healthy and positive environment for scientific research activities,and promote the comprehensive construction and long-term development of scientific research integrity construction.