The polymorphism of cytotoxic T lymphocyte associated antigen-4 (CTLA-4) was investigated by PCR-RFLP in 28 healthy volunteers and 64 patients with Graves′ disease (GD). The result suggests that the frequency of G49 allele of CTLA-4 exon 1 in GD patients issignificantlyhigherthanthat in normal controls (P

sFas and Bcl-2 in serum were detected by ELISA in 30 patients with Graves′ disease (GD) before and after treatment 〔(0.76?0.24)ng/L vs (1.02?0.23)ng/L, (0.52?0.08)ng/L vs (0.87?0.15)ng/L〕 and in normal control subjects 〔(0.53?0.09)ng/L; (0.81?0.15)ng/L〕, the results indicated that sFas and Bcl-2 seem to be involved in the pathogenesis of GD.

Plasma homocystein (Hcy) level and 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism were investigated in 50 normal subjects, 32 cases of hypothyroidism and 48 cases of hyperthyroidism. As compared with normal group, plasma Hcy level was increased in hypothyroidism group (P