OBJECTIVE:To investigate the possible mechanism of metoprolol in reducing the mortality of acute myocardial infarction (AMI).METHODS:60 AMI subjects were randomly divided into two groups,the treatment group was administered with metoprolol besides the conventional therapy administered in the control group,the two groups were compared in respects of the occurrences of malignant arrhythmia and the relapse of myocardial infarction,QT divergency (QTd)and left ventricular remodeling (LVRM)indexes.RESULTS:Compared with the control group,the malignant arrhythmia and myocardial infarction relapse cases were significantly decreased in the treatment group(P

OBJECTIVE:To observe the effects of gelodipine on plasma ghrelin level and endothelial function of blood vessels in patients with essential hypertension.METHODS:A total of 77 patients with essential hypertension were randomly divided into trial group(n=45)and control group (n=32).Both groups were given low sodium diet,proper exercise, weight reduction and oral diuretics,while the trial group was assigned to receive felodipine 5mg q.d additionally.The course of treatment was 8wk.Before and after the treatment,plasma levels of ghrelin and nitrous oxide(NO),endothelin(ET-1),and brachial artery flow-mediated dilatation(FMD)function were observed.RESULTS:Plasma levels of ghrelin and NO,and FMD were significantly increased (P0.05).CONCLUSION:Felodipine can increase plasma Ghrelin level meanwhile improving endothelial function of blood vessels in patients with essential hypertension.

OBJECTIVE: To study the effect of allopurinol on the function of blood vessel endothelium in patients with essential hypertension complicating hyperuricemia. METHODS: 65 cases with essential hypertension complicating hyper uricemia were randomized into treatment and control group. The control group was given the classic non- pharmacotherapy: reduced intake of sodium, more exercise, weight loss etc. The treatment group was treated wilh 100mg allopurinol b.i .d for 4 weeks besides the classical non - pharmacotherapy as stated for the control group. Serum uric acid level, brachial artery flow -mediated diastolic (FMD) function, the base internal diameter of brachial artery, nitrogen oxide (NO), von Willebrand' s factor(vWF) were compared between two groups before and after treatment. RESULTS: As compared with prior treatment, the treatment group had decreased level of uric acid and decreased vWF level, increased level of NO and a significantly increased level of FMD, all had statistical significances(P0.05) . CONCLUSION: Allopurinol can ameliorate the function of blood vessel endothelium in patients with essential hypertension complicating hyperuricemia.

Objective: To analyze the association between different sleep behaviors and overweight and obesity of junior high school students in Yangzhou City, and to provide a basis for policies and interventions related to adolescent health management. Methods: A total of 1 589 students in grades 7-9 from two middle schools in Yangzhou City were selected using the cluster sampling method and were administered with sleep time, bedtime, social jetlag difference, and sleep habits. Results: Totally 64.38% were sleep deprived during the school days, 86.78% went to bed too late, 46.51% had a social jetlag of ≥1 h, and 37.44% took a nap every day(Incluldes holidays and school days). Social jetlag length was statistically different between grades( F =6.97, P < 0.01 ). Girls[(0.95±0.65)h] shown significantly higher social jetlag than the boys[(0.76±0.59)h]( t=6.19, P <0.01). Later bedtime on weekends, later wake up time on weekends and poor sleep behavior were risk factors for overweight and obesity in junior high school students( OR=1.20, 1.14, 1.04, P <0.05). Conclusion Junior high school students had less sleep and later bedtimes with the increase of grade, and weekend bedtimes,wake up times and poor sleep behavior were independently associated with the risk of overweight and obesity in junior high school students. Parents and schools should be instructed to pay attention to their sleep health and carry out adolescent sleep health guidance.