1.Telomerase activity and P53 expression in Non-small cell lung cancer and their significances
Tonghua MEI ; Liping ZHANG ; Yuequan JIANG
Journal of Third Military Medical University 2001;23(2):138-139
Objective To investigate the significances of telomerase activity and P53 expression in Non-small cell lung cancer (NSCLC). Methods The activity of telomerase in cancerous tissues was detected by PCR-ELISA, and the expression of P53 protein was detected by S-P method. Results The telomerase activity and P53 expression were significantly higher in NSCLC tissues than in normal lung tissues. The telomerase activity and P53 expression had close association with the differentiation of cancer cells and lymph node metastasis. Conclusion It is very valuable to measure telomerase activity and P53 expression in studying the initiation and progression of NSCLC.
2.Clinical Observation on Treatment of Post-operative Gastrointestinal Syndrome with Combined Acupuncture and Herbs
Pai WANG ; Yuequan ZHANG ; Guoqing CHU
Journal of Acupuncture and Tuina Science 2006;4(1):44-46
Objective: To observe the therapeutic effect of treating postoperative gastrointestinal syndrome with combined needles and herbs. Method: Altogether 117 in-patients were randomly allocated into the treatment group of 86 cases and control group of 31 cases. Point injection was mainly adopted in the treatment group plus Chinese herbal decoction, while Western medicine was adopted in the control group. And then the therapeutic effect of the two groups was compared. Result: The total effective rate of the treatment group and control group were 96.5% and 80.6% respectively, and the treatment course of the treatment group was significantly shorter than the control group (P < 0.01). Conclusion: Combined needles and herbs have excellent effect in treating postoperative gastrointestinal syndrome and were superior to Western medicine.
3.Spectral analysis and LDB based classification of heart sounds with mechanical prosthetic heart valves.
Di ZHANG ; Yuequan WU ; Jianping YAO ; Song YANG ; Minghui DU
Journal of Biomedical Engineering 2011;28(6):1207-1212
Auscultation, the act of listening for heart sounds to aid in the diagnosis of various heart diseases, is a widely used efficient technique by cardiologists. Since the mechanical prosthetic heart valves are widely used today, it is important to develop a simple and efficient method to detect abnormal mechanical valves. The study on five different mechanical valves showed that only the case of perivalvular leakage could be detected by spectral estimation. Though it is possible to classify different mechanical valves by using time-frequency components of the signal directly, the recognition rate is merely 84%. However, with the improved local discriminant bases (LDB) algorithm to extract features from heart sounds, the recognition rate is 97.3%. Experimental results demonstrated that the improved LDB algorithm could improve classification rate and reduce computational complexity in comparison with original LDB algorithm.
Algorithms
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Heart Sounds
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physiology
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Heart Valve Diseases
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physiopathology
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surgery
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Heart Valve Prosthesis
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Heart Valves
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physiopathology
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Humans
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Pattern Recognition, Automated
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Phonocardiography
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Signal Processing, Computer-Assisted
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Spectrum Analysis
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methods
4.Limbic encephalitis: a new type of autoimmune encephalopathies
Huifang ZHANG ; Yuanpeng WU ; Zongrong XU ; Yuequan ZHAO
Chinese Journal of Neuromedicine 2016;15(5):533-535
Limbic encephalitis is a new type of autoimmune encephalopathies.The clinical manifestation is primarily defined by the subacute onset of short-term memory loss,seizures,confusion and psychiatric symptoms.The diseases usually have a variety of clinical manifestations,and are very serious,occurring with or without tumor association.Routine detection of serum and cerebrospinal fluid (CSF) and imaging tests show no specificity,but associated antibodies can be detected in serum and (or) CSF.Early identification,tumor resection and immunotherapies are helpful in improving the prognosis of patients.This article aims to study the pathogenesis,classification,clinical features and treatment of antibody-associated limbic encephalitis and to improve the diagnosis and prognosis of the disease.
5.Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy.
Shenwu ZHANG ; Yuequan WANG ; Zhiqiang KONG ; Xuanbo ZHANG ; Bingjun SUN ; Han YU ; Qin CHEN ; Cong LUO ; Jin SUN ; Zhonggui HE
Acta Pharmaceutica Sinica B 2021;11(11):3636-3647
Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG
6.Blocking Adenosine/A2AR Pathway for Cancer Therapy.
Jia LIU ; Yuequan SHI ; Xiaoyan LIU ; Dongming ZHANG ; Yu BAI ; Yan XU ; Mengzhao WANG
Chinese Journal of Lung Cancer 2022;25(7):460-467
Adenosine is a metabolite produced abundantly in the tumor microenvironment, dampening immune response in inflamed tissues via adenosine A2A receptor (A2AR) which is widely expressed on immune cells, inhibiting anti-tumor immune response accordingly. Therefore, blocking adenosine signaling pathway is of potential to promote anti-tumor immunity. This review briefly introduces adenosine signaling pathway, describes its role in regulating tumor immunity and highlights A2AR blockade in cancer therapy. Prospective anti-tumor activity of adenosine/A2AR inhibition has been revealed by preclinical data, and a number of clinical trials of A2AR antagonists are under way. Primary results from clinical trials suggest that A2AR antagonists are well tolerated in cancer patients and are effective both as monotherapy and in combination with other therapies. In the future, finding predictive biomarkers are critical to identify patients most likely to benefit from adenosine pathway blockade, and further researches are needed to rationally combine A2AR antagonists with other anti-tumor therapies.
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Adenosine/therapeutic use*
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Adenosine A2 Receptor Antagonists/therapeutic use*
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Humans
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Lung Neoplasms
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Receptor, Adenosine A2A/metabolism*
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Tumor Microenvironment