Objective To observe the clinical effect ofShuganJieyu capsule combined with domperidone on functional dyspepsia (FD).Methods84 FD patients were recruited in this study. The patients were divided into the control group (n=42) and the observation group (n=42). Control group was treated with domperidone, and observation group was treated with combination ofShuganJieyu capsule and domperidone. Both groups were treated for 4 weeks. The gastric volume, gastric gas scores, and gastric emptying rates were detected by the ultrasound and X-ray. The clinical effect and adverse reactions was compared.ResultsThe clinic effective rate of observation group was 90.5% (38/42), and the control group was 76.2% (32/42). After treatment, the gastric volume of 60 min was significantly lower in observation group than that in control group (15.52 ± 3.21 mlvs. 23.54 ± 5.11 ml;t=2.412,P<0.05); the decreasing of gastric gas scores (0.42 ± 0.13vs. 0.64 ± 0.16;t=2.384,P<0.05) and increasing of gastric emptying rate (74.15% ± 11.62%vs. 54.82% ± 10.31%;t=2.324,P<0.05) were significantly higher in observation group than those in control group.ConclusionShugan-Jieyu capsule can improve gastric emptying and gastrointestinal motility, and showed better effect than domperidone alone.

Objective: Based on observational, longitudinal and intervention study of common diseases among students in Jiangsu Province, this paper presents the current progress of two year follow up of myopia cohort regarding the association between growth parameters with progression of myopia among children and adolescents in areas with rapid economic growth. Methods: This survey adopted the stratified cluster sampling method for school selection. The full automatic computer optometry (TOPCON RM800) was used to track myopia related parameters for all participants from 2019 to 2020 under the condition of mydriasis (compound topicamide eye drops). Relationship between growth parameters of children and adolescents and the incidence and progression of myopia was analyzed by using Cox regression multiple statistical model. Results: The myopia rates of students from grade 1 to grade 3 in 2019 were 5.4%, 21.5% and 37.3% respectively. After one year, the myopia rates of all school stages increased to 25.3%, 43.3% and 58.1% respectively( χ 2=53.59, 49.63, 32.52, P <0.01). The mean diopter of right eye and left eye after mydriasis were ( 0.30± 1.24/0.39±1.26)D in 2019 and (-0.33±1.54/-0.19±1.55)D in 2020, respectively based on Cox multiple regression results, age ( HR =1.21, 95% CI =1.09-1.34), naked eye vision ( HR =0.08, 95% CI =0.07-0.11), height ( HR =0.98, 95% CI =0.97-0.99) showed a strong correlation with the incidence and progression of myopia( P <0.05). Conclusion Myopia is growing rapidly in the central region of Jiangsu Province. It is suggested that diopter, axial length, naked eye vision, age, height and other indicators should be included in the refractive archives of children and adolescents in the region.