Objective To investigate the influence of ulinastatin combined with Xue Bi Jing injection therapy on serum interleukin interleukin-8 (IL)-8 and γ-interferon (γ-IFN) of patients with severe acute pancreatitis(SAP).Methods Seventy patients with SAP were randomly divided into the control group(n=35) and research group (n =35).Patients in the control group were given ulinastatin on the foundation of traditional treatment,and in research group were given Xue Bi Jing injection on the foundation of treatment of the control group.The rehef time of abdominal distension and abdominal pain,time of serum amylase (sAMY) and white blood cell count(WBC) returned to normal were recorded.The IL-8 and γ-IFN of before and after treatment of the two groups were measured.Results The relief time of abdominal distension,abdominal pain,times of serum amylase,WBC returned to normal in treatment group were (4.1 ± 1.5) d,(4.2 ± 1.9) d,(5.2 ± 1.4) d,(6.5 ± 1.9) d respectively,significantly shorter than the control group((6.2±2.4) d,(6.5±2.2) d,(6.8±2.5) d,(8.9±2.5) d;t=5.468,5.747,4.354,4.647;P＜0.05).The IL-8 and IFN-γ at the 3rd.day and 7th day after treatment of the two groups decreased obviously,and those in the observation group were significantly lower than the control group (P ＜ 0.05).Conclusion Ulinastatin combined with Xue Bi Jing injection therapy can conspicuously reduce the IL-8 and γ-IFN levels in patients with severe acute pancreatitis and alleviate the clinical symptom.