Objective To analyze the clinical application of misoprostol in the painless induced abortion analgesia.Methods 80 cases of painless induced abortion in pregnant women were selected as the subjects.They were randomly divided into two groups by the digital table method.The control group was not given drug before opera-tion,the observation group was given oral misoprostol before operation.The blood loss, operation time and adverse reaction rate of the two groups were observed and compared.Results In the control group,blood loss[(82.13 ± 8.76)mL],operation time[(15.64 ±4.43)min],and adverse reactions rate(30.00%) were higher than those in the observation group[(46.51 ±5.31)mL,(11.36 ±3.22)min,7.50%],the differences between the two groups were statistically significant(t=4.57,3.36,χ2 =6.65,all P<0.05).Conclusion Oral misoprostol before operation could reduce the amount of bleeding during operation,shorten the operation time.It was worth of popularizing.