OBJECTIVE:To discuss the medication regularity of Chinese herbal compound formula for osteoporosis. METHODS:A total of 104 Chinese herbal compound formula for osteoporosis (OP) published from 1995 to 2005 were retrieved from China Hospital Knowledge Database(CHKD); and a database was set up using EXCEL2000 software,with the drug name of each herbal medicine in the compound herbal formula included and a statistical analysis was carried out.The herbs which were used frequently were subjected to data mining and analysis using association rules. RESULTS:Of the total 104 Chinese herbal compound formula for osteoporosis,leading the first 12 places in terms of application frequency in turn were prepared Rehmannia glutinosa,Herba Epimedii,Dioscorea opposita and Eucommia ulmoides,etc.In the association rule set,there were respectively 7,6,6 and 8 rules which respectively consisted of 2,3,4 and(5,6,7) herbs.CONCLUSION:The relationship between the three factors(renal deficiency,splenic asthenia,and blood deficiency) and osteoporosis were verified in the study of the Chinese herbal compound formula for osteoporosis.