Objective:To study the feasibility of using MRI in detection and qualitative analysis of atherosclerotic plaque in rabbits.Methods: The atherosclerotic model was established in rabbits with high cholesterol diet.The experimental animals received T_(1)WI,T_(2)WI,PDWI and TOF sequences scanning and B ultrasound examination.Results: The atherosclerotic model was successfully established in rabbits.T_(1)WI,T_(2)WI and PDWI sequences scanning showed thickening of aortal wall and the plaque showed equal,high or low signal intensities,which was in good accordance with the pathological examination results.The atherosclerotic plaques were successfully detected and analyzed by MR and MR had higher accuracy than ultrasound examination.Conclusion: MR can be used for detection of atherosclerotic plaque and for qualitative analysis of the plaque.

Objective To quantify iron deposition in Alzheimer’s disease (AD),amnestic mild cognitive impairment (aMCI), and normal old people using susceptibility weighted imaging (SWI).Methods Sixty participants (22 aMCI,20 AD,18 normal con-trols)underwent conventional magnetic resonance imaging sequences and SWI using axial/oblique coronal sequences.Phase images were used to calculate bilateral iron deposition in 1 8 regions of interest (ROI)of every participant.The radian angle values were cal-culated and compared between the three groups.Results The radian angle value difference was significant between the aMCI and control groups in the left (L)-hippocampus,L-head of the caudate nucleus,R/L-lenticular nucleus ROIs.The radian angle value difference was significant between the AD and aMCI groups in the R/L-cerebellar hemisphere,R/L-hippocampus,R-red nucleus, R/L-thalamus and splenium of corpus callosum ROIs.Pearson correlation coefficients of the mini-mental state examination (MMSE)scores and many ROIs were significant.Conclusion Iron depositions in the hippocampus,head of the caudate nucleus,len-ticular nucleus and thalamus are significantly different between individuals with aMCI,AD and controls.Using SWI to quantify the iron deposition is a useful tool in detecting aMCI and AD.

Objective: To evaluate the effects of the combined radiofrequency (RF) with oral appliance (OA) therapy on obstructive sleep apnea(OSA). Methods: 15 patients with OSA were diagnosed by overnight monitoring of polysomnography(PSG).They all received bi-polar radiofrequency treatment on palate twice.Polysomnography were taken for the patients 6 weeks after the second RF treatment. 10 cases without TMJ disease and periodontal disease with more than 10 teeth on each of maxillae or mandibulae were treated with OA. Reexamination of PSG was taken one month after application of OA.Statistic analyses were made in the measurements of PSG. Results:PSG measurements showed sleep improvement after treatment(P

Although digital subtraction angiography (DSA) has been used as the gold standard for the diagnosis of intracranial aneurysms, its clinical use is somewhat limited by its invasiveness, high medical cost and potential risk of nephrotoxicity. For the past three decades, the magnetic resonance angiography (MRA) techniques have been developed rapidly. As a non-invasive technique with high resolution ability, MRA can replace DSA for the diagnosis of intracranial aneurysms in most clinical situations. The time-of-flight MRA (TOF-MRA) carries a diagnostic sensitivity of up to 98.2%-98.7%for tiny intracranial aneurysms (<5 mm), while the diagnostic sensitivity and specificity of contrast enhanced MRA (CE- MRA) for intracranial aneurysms are as high as 95% - 100% and 73% - 100% respectively. The diagnostic specificity of phase-contrast MRA (PC-MRA) for intracranial aneurysms (> 5 mm) reaches as high as 100%. All the above mentioned MRA techniques can clearly display the intracranial aneurysms although their imaging characteristics and clinical applications are different from each other. This paper aims to make a brief review concerning the principles, clinical applications and recent progress of some MRA techniques.

Objective To investigate the changes of soft and hard tissues after extraction space closure with micro-screw implant as orthodontic anchorage. Methods Twenty cases were selected randomly with the first premolars extraction. Micro-screw implant was used as orthodontic anchorage. Sliding technique was used to close the extraction space. The lateral cephalograms before and after the treatment were evaluated.Results The upper incisors moved 7. 15 mm palatelly, 1. 63 mm intruded. The upper first molar moved 0. 80 mm distally, 1. 80 mm intruded. The lower incisors moved 4. 65 mm distally, 0.48 mm extruded. The lower first molar moved 0. 18 mm mesially, 1.18 mm extruded. A point, B point, upper lip, lower lip showed distal movement. Conclusions Micro-screw implant can provide acceptable and reliable anchorage in the process of extraction space closure, and improve the profile. Besides, it produces skeletal change on the maxilla.

This review summarized some hot research fields in pharmacological effects of sinomenine such as anti-inflammatory, immunosuppressive, and anti-tumor effects. In addition to our exploration of its antinociceptive effect, we summarized above-mentioned pharmacological effects of sinomenine and its underly-ing mechanism, in order to provide an evidence for its clinical use.

Objective To study the effect of hand intrinsic muscle exercise on postoperative recovery of fine movement in children with hand injury.Methods From January 2009 to December 2011,64 children with hand injury were randomly divided to exercise group and control group equally.Hand intrinsic muscle exercise and rehabilitative care were conducted in the exercise group while traditional rehabilitative therapies in control group.After 3-month therapy,MMDT(Minnesota Manual Dexterity Test)and PPT(Purdue Pegboard Test)were conducted to evaluate the functional recovery of hands.Result The results of MMDT and PPT were obviously better in the exercise group than in the control group(P<0.01).Conclusion Hand intrinsic muscle exercise may be effectively in promoting the recovery of fine movement in children with hand injury.

Objective To investigate the clinical efficacy of rhubarb acupoint sticking joint shuganjieyu diet in the treatment of chronic functional constipation patients with depressive anxiety.Methods 120 patients of chronic functional constipation with depression anxiety were selected,they were randomly divided into control group and obser-vation group,60 cases in each group.The patients in the control group were given promoting gastrointestinal motility drugs mosapride capsules,and orally given laxatives rhubarb with sodium bicarbonate.The patients in the observation group were treated with topical rhubarb acupoint,and orally given medicated shuganjieyu diet.7 days for a course of treatment,the patients were treated for four courses.The clinical efficacy of the two groups,defecation interval and fecal nature,SAS,SDS scale score changes and quality of life (PAC -QOL)scale score changes before and after treatment and adverse reactions during treatment were recorded.Results The total effective rate of the observation group was 90.00%,which of the control group was 91.67%,the difference between the two groups was not significant (χ2 =0.32,P >0.05).Before treatment,the bowel movement and stool ratings between the two groups had no statis-tically significant differences (t =0.23,0.33,all P >0.05).After treatment,the two points of the two groups were significantly decreased,but the differences between the two groups were not significant (t =0.18,0.41,all P >0.05).Before treatment,the SAS,SDS scale scores between the two groups had no statistically significant differences (t =0.78,0.69,all P >0.05).After treatment,the SAS,SDS scores of the two groups were significantly decreased, which of the observation group decreased more significantly than those of the control group (t =4.18,4.72,all P <0.05).Before treatment,the PAC -QOL scale scores for each dimension level had no statistically significant differ-ences (t =0.16,0.21,0.42,0.20,all P >0.05).After treatment,the dimensions of the two groups showed a decline trend,and those of the observation group decreased more significantly than the control group (t =2.10,3.56,2.76, 2.34,all P <0.05).In the control group during the treatment,2 cases of diarrhea,three cases of dry mouth,the patients were improved after given symptomatic treatment.No serious adverse event occurred during therapy in the observation group.Conclusion Rhubarb acupoint joint shuganjieyu diet in the treatment of chronic functional constipation patients with depression anxiety has significant clinical effect,which can significantly improve patients'depression and anxiety scores,quality of life,and without significant adverse reactions,it is worthy of clinical applica-tion.

Objective To investigate whether the extact of ginko biloba (EGb761) can protect the retinal ganglion cells (RGC) after acute high intraocular pressure induced retinal ischemia-reperfusion injury. Methods Thirty Sprague-Dawley rats were randomly divided into three groups. The negative control group, positive control group, treatment group were given normal saline 5 mL/kg, 1% erigeron breviscapus (vant) hand-mazz (EBHM) 5 mL/kg, 1% EGb761 5 mL/kg, respectively 2 hour after injury and every day after operation. Retinal ganglion cells were retrograde labeled by injection of 3% fluorogold (FG) into both side of superior colliculus 5 days before the death of the rats. Results The average survival rate of retinal ganglion cells were 61.46%, 72.73% and 76.20% in negative control group, positive control group and treatment group respectively. Conclusion EGb761 has neuroprotective effect on retinal ganglion cells in acute high intraocular pressure induced retinal ischemia-reperfusion injury.

Objective To observe the preventative and curative effect of Tongxinluo on microvascular inflammatory injury and vasospasm in the cardiac muscle of streptozotocin (STZ) diabetic rats. Methods STZ rats were divided into STZ group, insulin group, Tongxinluo group, with the other 8 Wistar rats as normal control. The normal group and STZ group were intragastric administered with NS, insulin group was subcutaneous injected with insulin, and Tongxinluo group was intragastric administered with Tongxinluo suspension for 8 weeks. The sections of cardiac muscle was stained in HE staining and NF-?B immunohistochemical staining. The level of adhesion molecule-1 (sICAM-1), tumor necrosis factor (TNF-?), endothelin-1 (ET-1), angiotensin-Ⅱ (AT-Ⅱ) in myocardial homogenate from intercellular, and level of AT-Ⅱ, neuropeptide Y (NPY) in plasma were determined, with sICAM-1 by enzyme-linked immunosorbent assay and the others by radioimmunoassay. The sections stained by NF-?B immunohistochemical staining were image analyzed using computer. The extent of its expression was evaluated by the mean of the density ratio of the positive side. Results Compared with normal rats, the content of sICAM-1, TNF-?, ET-1, AT-Ⅱ and the expression of NF-?B in the myocardial homogenate of STZ rats was increased (P0.05). AT-Ⅱ in plasma of STZ rats increased (P