DC group.IL-12 secretion in IL-18/fusion group was higher than that in the fusion group,and IL-12 in the pulsed DC group was higher than that in the DC group.The in vitro killing rates of the 4 groups were 79.73%,50.68%,35.81% and 4.05%,respectively.Tumor forming time in IL-18/fusion group([12.82?2.85]d) was longer than those in the pulsed DC group([8.52?1.97]d,P

0.05).The positive rates of CD1a and CD83 in IL-18+TNF-? group were higher than those in other 2 groups.The positive rate of HLA-DR in IL-18+TNF-? group was higher than that in IL-18 group.No difference between IL-18 group and TNF-? group in the potency of stimulating T cell proliferation was found,whereas the stimulating potency in IL-18+TNF-? group was higher than that in IL-18 group and TNF-? group.IL-12 in IL-18+TNF-? group at 48 h and 72 h was higher than that in IL-18 group and TNF-? group(P

Diabetes is a common chronic non-infectious disease. Diabetic patients not only suffer from metabolic disorders, but are also prone to immune deficiencies and are at a higher risk of being infected with human papillomavirus (HPV). Many studies at home and abroad have shown that the HPV infection rate of patients with diabetes is higher than that of non-diabetic patients. Patients with diabetes can benefit from HPV vaccination, and the tolerance is good. HPV vaccination is recommended for diabetic patients. This article reviews the research on diabetes, HPV infection, and HPV vaccine, which will provide references for HPV vaccination in diabetic patients.