OBJECTIVE:To facilitate the construction of Chinese pharmaceutical profession associations. METHODS: We analyzed the current situation and problems existing in Chinese pharmaceutical profession association as well as the developmental experience of foreign pharmaceutical associations then put forward suggestions for the development of pharmaceutical profession associations in China. RESULTS & CONCLUSIONS: The sound development of pharmaceutical profession associations calls for the cooperated efforts of government, profession association and pharmaceutical enterprises, meanwhile its function as bridge and tie between pharmaceutical enterprises and government should be brought into full play.

Arthralgia ; etiology ; Arthroplasty, Replacement, Knee ; adverse effects ; Humans ; Knee Joint ; surgery ; Pain, Postoperative ; etiology

Humans ; Pulpitis ; diagnosis

ObjectiveTo evaluate the correlation of peripheral IL-10/IL-17 expression and pulmonary function in children withMycoplasma pneumoniae pneumonia (MPP).MethodsChildren with MPP (n=66) were recruited and divided into MPP gasp groups (n=31) and MPP no-gasp group (n=35) based on whether pulmonary wheezing sound exists. Another 30 healthy children were recruited as control group. ELISA was used to detect the level of interleukin - 6 (IL - 6) and transforming growth factor-β (TGF-β). The peak expiratory lfow (PEF), forced expiratory volume in 1 s (FEV1), forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) and lung capacity maximum expiratory lfow (V75, V50, V25)were detected by pulmonary function instrument.ResultsThe serum IL-10 level of MPP gasp groups, MPP no-gasp group and control group were(8.1±1.8) ng/L,(13.3±2.0)ng/L and(18.4±1.7)ng/L, respectively; the serum IL-17 level were(23.8±2.3)ng/L,(16.2±1.5)ng/L and (11.4±1.0)ng/L, respectively; which showed signiifcant differences between each group(P<0.05). The PEF, FEV1 and FEV1/FVC of MPP gasp groups were(71.4±5.7)%,(71.8±6.3)% and 72.5±9.6; and those of MPP no-gasp group were(95.3±7.8)%, (96.2±10.5)% and 85.3±4.5; which showed signiifcant differences between the two groups(P<0.05). The V75, V50 and V25 were(74.7±5.0)%,(45.2±10.3)% and(38.3±8.7)%, and those of MPP no-gasp group were(85.6±4.2)%,(75.9±9.5)% and (66.1±12.5)%. Pearson correlation analysis showed that PEF, FEV1, V75, V50 and V25 had positive correlation(P?0.05)with the level of IL-10 and f IL-17 (bothP?0.05).ConclusionMPP children have IL-10/IL-17 imbalance, and the expression of IL-10/IL-17 was correlated with pulmonary function changes.

10.3969/j.issn.2095-4344.2013.24.023

Because of the neonatal immune system is immature,particularly in preterm and low birth weight infants,the neonate is prone to some infections.Neonatal sepsis usually has the slight performance and atypical clinical symptoms,which raise the great interest of searching for some better biomarkers.With the development of testing technology,the research of serum inflammation marker has made remarkable progress at home and abroad in recent years,however,the research of umbilical blood inflammation marker is still in the early stage of exploration.Umbilical blood detection have the advantages of early,noninvasive,safe and convenient compare to the traditional serum detection.This paper mainly discusses the application of umbilical blood detection to early onset neonatal sepsis.

Objective To explore the correlation between the MSCT sign of gastric cancer and the expression of human epidermal growth factor receptor 2 (HER2)gene in the cancer tissues.Methods 105 cases of gastric cancer diagnosed by pathology after sur-gery underwent MSCT before surgery,then the correlation was analyzed between MSCT shows and the expression of HER2 gene detected by immunohistochemistry after surgery by the statistical method.Results The age,sex,site of tumor,stage and CT value of plain scan were not correlated with the expression of HER2 (P>0.05).Compared to the group without HER2 expression,CT value in venous phase,the enhancement degree in both arterial and venous phase and the incidence of enlarged lymph nodes around the stomach were higher in HER2 positive expression group,the differences were significant (P<0.05),while CT value in arterial phase were not significantly different (P>0.05).Compared to the HER2 (0&1+)group,CT value,the enhancement agree in venous phase and the incidence of enlarged lymph nodes around the stomach were higher,in HER2 (2+&3+)group,the differences were significant (P<0.05),while CT value and the enhancement in arterial phase were not significantly different (P>0.05).Conclusion There are different signs in MSCT with different expression of HER2 in gastric cancer,the combinations of them can evaluate the prognosis of gastric cancer.

Objective To explore the double center teaching model in the application of emergency nursing teaching effect. Methods 120 higher vocational nursing students were randomly divided into experimental group(60) and control group(60). The experimental group used the double-center teaching mode, while the control group used traditional teaching mode. At the end of the course, students of both groups were given theoretical examination and skills examination, and the experimental group students' self-evaluation was surveyed by questionnaire . The obtained data were statistically analyzed using SPSS 12.0 software, with the test scores represented by (x±s), questionnaire, investigation with percentage statistics and comparison between groups with t test. The difference was statistically significant ( P=0 . 034、0 . 016、0 . 000 ) . Results The experimental group's theory achievement , case analysis result and practical result were all higher than those of the control group, and the difference was statistically significant (P=0.034, 0.016, 0.000). 93.33% of nursing students thought that double main teaching effect was better; 88.33% of nursing students thought it could develop their ability to learn independently;86.67%of nursing students thought it could enhance the team cooperation spirit;85.00%of nursing students thought that it could improve the efficiency of first aid knowledge learning and first aid skills. Compared with t test between groups, the difference was statistically significant, (P<0.05 ). Conclusion The double-center teaching mode is an effective model to improve the effect of emergency nursing teaching, and it will provide the basis for other disciplines teaching reform.

Objective To discuss clinical value of the detection of Mycoplasma pneumoniae IgG with antibody (MP‐IgG) and the serum total IgE in child pneumonia .Methods Detected the serum M P‐IgG and total IgE in 480 cases of hospitalized children pa‐tients with pneumonia ,and grouped by the results of MP‐IgG .Results There was significantly difference between each category in study group and control group on the positive rate and concentration of serum total IgE(P<0 .05) ,comparison of the positive rate and concentration of serum total IgE between each category in study group had statistically significant differences(P<0 .05) .There was a positive correlation between the positive rate and concentration of IgE with the titer of MP‐IgG(R2 was0 .957 1 and 0 .917 7 respectirely) .Conclusion The combined detection of serum MP‐IgG and total IgE could provide reference for diagnosis of Myco‐plasma pneumonia and basis for clinical treatment .

Colorectal cancer is one of the most common malignant tumors,with the improvement of living standards and eating habits of Westernization.The incidence and mortality of colorectal cancer are on the rise in China.The development of colorectal cancer is a multi-step,multi-gene involved in the process.At present,chromosome instability(CIN)and microsatellite instability(MSI)are considered to be the main genetic pathways in colorectal cancer.This article reviews research progress of MSI colorectal cancer in clinical pathology and molecular characteristics.