OBJECTIVE: To explore the anti-tumor and immunologic enhancement effects of Xiangling capsule.METHODS: The tumor-inhibition experiment was conducted in vivo in accordance with the screening criteria of anti-tumor drugs.Mice were treated with cyclophosphamide to induce hypoimmunity model.The effect of Xiangling capsule on mice was tested by determining leukocyte count,thymus index,spleen index,and the activity of NK cells.RESULTS: Xiangling capsules at different concentration showed inhibition on the growth of mice-transplanted tumor S180,H22 hepatomas and Lewis lung carcinoma with inhibition rates of 44.8%,52.2 %,and 43.3%,respectively(P

OBJECTIVE:To promote the implementation of essential medicine system by combining drug utilization research with national essential medicine system. METHODS:The importance of information monitoring in the implementation of essential medicine system was analyzed and the application of drug utilization research in the implementation of essential medicine system was also discussed. RESULTS & CONCLUSIONS:It is suggested that the indicators for example DDDs are used in the monitoring of clinical drug utilization,and conditions also should be created to carry out further research of drug utilization so as to promote the implementation of essential medicine system in China.

Hepatocyte growth factor participates in many gynecologic and obstetric diseases such as gynecological tumor,endometriosis and hypertensive disorder complicating pregnancy by combination with its receptor c-Met.This article reviews the expression and mechanism of HGF in these diseases.

Adult ; Dust ; Female ; Glass ; Humans ; Male ; Middle Aged ; Occupational Diseases ; epidemiology ; Prevalence ; Skin Diseases ; epidemiology ; Young Adult

At the beginning of the 1980s, a concept of viable but non-culturable(VBNC) was suggested. VBNC is a survival strategy adopted by microorganisms when they are exposed to environmental stress. This article try to make a summary of research of the conditions of VBNC formation, recovery of culturability and methods of VBNC cells detection. In addition, introduces the first growth factor of microorganisms-Rpf.

Objective To observe the effect of sequential selection catheter combined with anisodamine in neurology catheterization patients about urine leakage to seek a new care pathway.Methods 240 cases of hospitalized neurology patients with indwelling catheter for a long time were randomized.The control group received conventional fixed-size catheter.According to the individual patient situation,the observed patients choose smallest model applicable Foley catheter when the initial catheterization,and increase the model sequential in turn periodic replacement of the catheter.The patients with leakage of urine were given anisodamine 10mg intramuscular injection,observe urine leakage rate of patients.Results The urine leakage rate was 6.67％ in the observation group which was significantly lower than 20.83％ in the control group(x2 =10.15,P ＜ 0.05),the intramuscular anisodamine efficient was 32/33 (96.97％).Conclusion Sequential selection catheter can significantly reduce the occurrence of urinary leakage,for patients with leakage of urine,anisodamine intramuscular injection can effectively control the leakage of urine,thereby greatly reducing the patient's pain.

BACKGROUND:Patellar tendinopathy is tiny damage at tendon insertion.Changes in the strength balance between medial vastus muscle(VM)and musculus vastus lateralis(VL)in the quadriceps may lead to patellar abnormal motion,even have an impact on the tendon insertion.OBJECTIVE:To compare and analyze knee mechanical charactedstics and surface electromyography of the quaddceps in athletes with patellar tendinopathy.in order to provide scientific basis for the prevention and treatment of patellar tendinopathy.DESIGN,TIME AND SETTING:Self-control experiment was performed in Central Laboratory of Physical Education College of Soochow University from June to July 2009.METHODS:A total of 10 athletes with patellar tendinopathy aged(21.44±1.51)yeam were selected as patellar tendinopathy group and 10 normal athletes aged(21.37±1.36)years were selected as normal control.MAIN OUTCOME MEASURES:①Knee flexor and extensor muscles peak torque in concentric and eccentric isokinetic exercise between two groups.②Comparison of quadnceps integrated electromyogram(IEMG)between two groups.③Comparison of VM/VL in different kinds of exercises between groups.RESULTS:The ratio of flexor and extensor peak torques of the patellar tendinopathy group was significantly greater than the normal group in concentric and eccentric isokinetic exercises(P＜0.05 or 0.01).VM IEMG of the patellar tendinopathy was significantly less than normal group(P＜0.05 or 0.01),but no difference was found in VL and rectus femoris IEMG between two groups.During the period of isometric exercise and isokinetic exercise,the ratios of VM/VL of the patellar tendinopathy group were remarkably lower than the normal group (P＜0.05 or 0.01).CONCLUSION:There are significant differences between flexor and extensor torques in patellar tendinopathy athletes.VM is under-activity and there is an imbalance between VM and VL.

Urid acid is one of the terminal metabolites of human body.More and more attention was paid to its metabolic mechanisms in intestinal tract;however, few studies were seen so far.This study aims to illuminate the metabolic mechanism of uric acid in intestinal tract by two ways:one is the transporters associated with intestinal epithelium, including ABCG2 and SLC2A9, the other is decomposition of uric acid by intestinal flora.We hope this review can provide new insights to decrease blood uric acid and treat urate-related diseases, and also provide a new way to alleviate drug-induced kidney damage.

Objective To compare the clinical value of nerve stimulator-versus ultrasound-guided continuous femoral nerve block for analgesia after laparoscopic surgery.Methods Forty patients,aged 18-60 yr,with body mass index of 18-30 kg/m2,of ASA physical status Ⅰ or Ⅱ,scheduled for elective laparoscopic surgery,were randomly assigned into 2 groups (n =20 each) using a random number table:nerve stimulator group (group S) and ultrasound group (group U).Epidural anesthesia was performed with 1.73 ％ carbonated lidocaine in both groups.0.2％ ropivacaine 5 ml/h was infused continuously after surgery to perform femoral nerve block for analgesia.VAS score at rest was assessed at 2,6,24 and 48 h after surgery.At 24 and 48 h after surgery,VAS scores during active and passive movement were assessed.The time for catheter placement near the femoral nerve and development of subcutaneous hematoma at the puncture site,local anesthetic intoxication and nausea and vomiting were recorded.The postoperative requirement for analgesics was also recorded.Results There was no significant difference in the VAS scores and puncture for femoral nerve block-and local anesthetics-related adverse events between the two groups.The time for catheter placement near the femoral nerve was 8.0 ± 1.4 and (6.7 ± 0.9) min in S and U groups,respectively,and the time was significantly longer in group S than in group U.No patients required rescue analgesic after surgery in both groups.Conclusion Nerve stimulator-guided continuous femoral nerve block provides higher clinical value than ultrasound-guided continuous femoral nerve block for analgesia after laparoscopic surgery and it is more suitable for clinical application.

Objective To introduce a new computer-assisted external frame for osteotomy to correct complex tibial and fibular deformity.Methods From January 2012 to December 2013,15 patients with complex tibial and fibular deformity were treated with a computer-assisted external frame and related computer software for surgical correction.All were unilateral limb deformity,involving the left lower limb in 8 cases and the right lower limb in 7 cases.They were 8 males and 7 females,15 to 43 years of age (average,26.8 years).The deformity was caused by old osteomyelitis in 9 cases and trauma sequela in 6.The related angles,distances and rotations were measured on the postoperative radiographs of the lower limbs.The data were input into the software to calculate the daily adjustment lengths of the frame rods.Daily frame adjustments were conducted according to the data calculated.The frame was removed when expected results were achieved.The patients lived independently during the adjustment.Results The 15 patients were effectively followed up for 10 to 22 months (average,15 months).Frame fixation time averaged 8.4 months (from 5.5 to 13.1 months).The reunion time averaged 8.0 months (from 5.4 to 12.1 months).The hospitalization time averaged 2.4 months (from 2.0 to 2.8 months).In 10 cases of limb shortening,the shortening lengths averaged 0.5 cm (from 0 to 0.9 cm) after adjustment.In 12 cases of angulation deformity,the angulation averaged 3.3° (from 0° to 5.4°) after adjustment.In 5 cases of rotation deformity,the maximum internal rotation was 5° and the maximum external rotation 10° after correction,deviating from the normal values by 3.5° on average.In 6 cases of horizontal displacement,the displacements averaged 0.5 crn after correction.All patients were satisfactory with corrected lower limb alignment,improved symptoms and appearance,giving a subjective satisfaction rate of 100％.Conclusion Use of computer-assisted external frame in surgical correction of tibial and fibular deformity can achieve satisfactory outcomes in simple,accurate,standardized,minimally invasive manners.