Objective To explore the effects of spironolactone on cardiovascular function in patients undergoing maintenance hemodialysis .Methods According to the random number table ,80 cases of patients undergoing maintenance hemodialysis in blood purification center of our hospital from December 2013 to June 2015 were randomly divided into the observation group and control group ,40 cases in each group .In the observation group ,patients were treated with spironolactone therapy ,while patients in the con‐trol group took a placebo .The cardiovascular function and related indexes were compared between the two groups .Results After 6 months of treatment ,the HR and BNP were decreased ,and CO ,SV ,SI and CI were increased in the observation group ,statistically significant differences were found in these indexes when compared with the control group (P<0 .05);there was no statistically sig‐nificant difference in HOI between the two groups(P>0 .05) .The PP ,MSP ,MDP ,MAP and ET‐1 in the observation group were significantly decreased after 6 months of treatment ,which were statistically different with those in the control group (P<0 .05) . Conclusion Spironolactone contributes to improving cardiovascular function of patients undergoing maintenance hemodialysis ,it is worthy of clinical application .

Laparoscope has been widely recognized as a treatment of distal gastric cancer.Totally laparoscopic distal gastrectomy and laparoscopy-assisted distal gastrectomy are two main types of laparoscopic distal gastrectomy.Apart from a smaller incision,some other advantages which totally laparoscopic distal gastrectomy has is the key point for further study.The thesis aims to compare totally laparoscopic distal gastrectomy to laparoscopy-assisted distal gastrectomy,and to analyze the characteristic in the aspect of operation time,the degree of pain,postoperative complications and the time of gastrointestinal recovery via collecting a great quantity of literatures.

Progressive assessment is one of the methods adopted by colleges and universities to evaluate the comprehensive quality of undergraduates.It can provide objective references for various awards and selections.Most colleges used static and transverse methods; based on these methods,advantages and disadvantages of individual undergraduates were compared with general groups,but feedback and forecast functions of assessment can not be realized.Therefore it is necessary to transform our conceptions and practice progressive assessment on comprehensive quality of undergraduates.We can learn from the relevant conceptions and methods in enterprise management and use data envelopment analysis to exclude the influence of different basic conditions of undergraduates.These undertakings are of great importance to truly reflect undergraduates' effective progress degree,guide them to test and evaluate themselves correctly and to advance comprehensive quality continuously.

Objective To learn healthy lifestyle and behavior literacy of residents living in Xicheng District of Beijing between 2008 and 2012 and to explore the influencing factors of healthy lifestyle and behavior literacy.Methods A total of 1 347 or 2 900 adults aged 18-60 years old were recurited from Xicheng District by using multistage stratified cluster sampling method in 2008 and 2012,respectively.Chisquare test and non-conditional logistic regression were used to analyze the effectiveness of 2-year intervention on healthy lifestyle and behavior literacy.Results The rate of healthy lifestyle and behavior literacy was 14.8％ vs.30.8％ in 2008 or 2012,respectively (x2=123.574,P＜0.05).For those with relatively lower education level (e.g.junior high school or below),the figure showed no statistically significant difference (x2=1.378,P＞0.05).In multivariate logistic regression analysis,female (odds ratio (OR)=1.350),education level (college/bachelor degree:OR=2.035,master degree or above:OR=2.554),monthly family income (＞5 000 RMB:OR=1.399) and investigation time (2012:OR=2.278) were influencing factors of healthy lifestyle and behavior literacy.Conclusion Remarkable improvement in healthy lifestyle and behavior literacy during 2012 as compared to 2008 could be attributed to the comprehensive interventions.In the future,those of low-literacy or low-income should be the mian target of modification of healthy lifestyle and behavior literacy.

Antineoplastic Agents ; pharmacology ; Cell Cycle ; Curcumin ; pharmacology ; Epithelial-Mesenchymal Transition ; genetics ; Gastrointestinal Neoplasms ; diagnosis ; etiology ; genetics ; metabolism ; Gene Expression Profiling ; Humans ; MicroRNAs ; genetics ; metabolism ; Neoplasm Invasiveness ; Tumor Suppressor Protein p53 ; metabolism

Objective To investigate the clinical significance of the glucose screening tests during pregnancy. Methods 1 516 cases of 24～28 weeks pregnant women were given 50g glucose screening tests, and for those whose blood glucose ≥7. 8 mmol/L further underwent glucose tolerance tests(OGTT) for a clear diagnosis. Results The incidence of gestational diabetes is 3.17% and the incidence of impaired glucose tolerance in pregnancy is 2. 64%. Conclusion 50g glucose screening for pregnant women helps to carry out early diagnosis and treatment of gestational diabetes,to improve the quality of obstetric and reduce perinatal mortality rate,it is of great significance.

ObjectiveTo confirm a suitable professional diathesis structure system of youthful teachers.MethodsThrough literature review and discussion of a small scale of specialists,the authors established the primary index system.Then Delphi method was taken to organize two rounds of specialist consultations,specialists' opinions were summarized,index name and weight were identified,and the professional diathesis structure system was established.ResultsA professional diathesis structure system of youthful teachers was established,which included seven first-level indicators:professional morality,learning level,teaching ability,scientific research ability,mental diathesis,self-developmental ability,collectivity spirit & society activities,and 35 second-level indicators.ConclusionBuilding scientific professional diathesis structure system of youthful teachers is necessary,which can provide a solid basis for building up cultivating mechanism for youthful teachers.

Objective To repair the experimental femoral head necrosis with the implantation of tricalcium phosphate (TCP) loaded with human bone morphogenetic protein-2(hBMP-2) gene transfected bone marrow derived mesenchymal stem cells(BMSCs). Methods Established the animal models of femoral head necrosis in 22 goats by the ligation of the lateral and medial circumflex femoral arteries and delivery of liquid nitrogen into femoral head. 4 goats served as the control group without any treatment. 3 weeks after surgery, necrotic bone in the other 18 goats were removed and TCP loaded gene transfer cells were implanted into the femoral head with BMP-2 gene transfected BMSCs in right side and ?-gal gene transfected BMSCs in left side. BMP-2 concentrations in femoral head were tested by the ELISA at 1st, 2nd, 3rd week after implantation. Histological observation was done before and at 6th, 10th, 16th week after implantation. New bone volumes (NBV) were measured at 16th week after implantation by the histomorphometry method. X-ray was taken at 16th week after operation in untreated group and after treatment in BMP-2 group and ?-gal group. Results The concentration of BMP-2 in femoral head of BMP-2 group was higher than that of ?-gal group at different time point. Empty lacunae and fibrotic marrow were demonstrated before implantation. New bone was evident in the implantation field of BMP-2 group while fibrous tissues were evident in that of ?-gal group at 6th, 10th and 16th week after treatment. Histomorphology analysis indicated that the NBV in BMP-2 group was significantly higher than that in ?-gal group. Articular surface collapse were observed in the X-ray photograph of untreated group. Regular shape and normal density of femoral head in BMP-2 group compared with the irregular shape and low density of femoral head in ?-gal group could be demonstrated in the X-ray photograph 16 weeks after treatment. Conclusion Implantation of the TCP loaded with human BMP-2 gene transfected BMSCs could repair early-stage experimental femoral head necrosis.

Objective:To explore the clinical application value of multi-slice spiral CT in the diagnosis.Methods: Twenty nine patients with clinically suspected rib fractures and X-ray showed no 64 row helical CT scanning in patients with chest trauma fractures after reconstruction, multiplanar reconstruction and VR imaging.Results: Twenty nine patients with occult fracture of rib on the MPR, VR imaging were rib image good, 28 cases were single, multiple rib fractures in 1 cases, the total of 4 cases with rib fracture, incomplete fracture in 25 cases.Conclusion: The 64 row helical CT for occult rib fracture detection rates, diagnostic accordance rate was superior to X-ray plain film, various post-processing techniques applied to timely, accurate, intuitive display rib fracture location, shape, extent of chest trauma, occult rib fracture first choice inspection method.

Objective To explore effective methods of nursing quality evaluation. Methods Guided by human-centered thinking,the new DRG quality indicators were formulated based on clinical investigation,literature review and expert consulta-tion. Then,the standards of the new indicators for radical masteetomy were identified by Delphi method and the reliability and validity were tested in 30 patients with radical mastectomy. Results The two new quality indicators were illness observation and health education. The Cronbach'α was 0.82 and 0.88 respectively. The results of expert consultation showed high content validity. Moreover,the new quality indicators got high commend by involved nurses. Conclusion The new quality indicators will lead nursing work to illness observation and health education,which will more benefit to reflect the true work of nurses and improve the internal quality of nursing.