MicroRNA (miRNA),an abundant class of small non-coding RNA,are abundant in the central nervous system where they play important roles in the neuronal development and plasticity.Moreover,the relationship between miRNA dysfunction and neurological diseases become more and more apparent.Recent studies show that the misregulated expression of miRNA out of control is closely related to the development of glioma.In this review we discussed the progress on the study of miRNA in Glioma.

The author got an opportunity to know about the Thai traditional medicine, especially its application and efficacy in treatment of Bi syndrome via the communication with Thai healers in the duration of teaching and working in Chandrakasem Rajabhat University due to an invitation.This paper will simply discuss the similarities and differences between the treatments with traditional Thai medicine and traditional Chinese medicine for Bi syndrome in terms of their theory systems, the understanding of Bi syndrome, as well as the characteristics of therapies.And I hope this paper will provide certain help in the academic exchanges between these two traditional medicines.

The management of hospital office is one of the important part of hospital management .The paper briefly introduces the functions and features of hospital office , analyzes the present situation and existing problems . By applying PDCA Circulation Method , we can improve and optimize the hospital office and constantly enhance the management level of hospital office .

Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulate in the bone marrow,where a complex microenvironment made by different cell types supports proliferation,survival,and drug resistance of tumor cells.MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at post-transcriptional level.Emerging evidence indicates that miRNAs are aberrantly expressed or functionally deregulated in MM cells as the result of multiple genetic or epigenetic mechanisms and that also the tumor microenvironment regulates MM cell functions by miRNAs.Consistently,modulation of miRNA levels in MM cells has been demonstrated to impair their functional interaction with the bone marrow microenvironment and to produce significant antitumor activity to overcome the protective bone marrowmilieu.This review will describe the most recent findings on miRNA function in the context of MM bone marrow microenvironment,focusing on the therapeutic potential of miRNA-based approaches.

The correlation between vegetarian diets and cardiovascular health is always one of the hotspots. Many scholars have performed so many clinical researches all over the world, providing evidence-based medicine (EBM) reference for clarifying their correlation. In this paper, we raise ideas and expectation on the basis of a Meta-analysis about vegetarian diets and blood pressure (published on JAMA Internal Medicine in Feb 2014) in combination of main clinical research literature in this field in recent 20 years.
Cardiovascular System ; Diet, Vegetarian ; Evidence-Based Medicine ; Humans ; Meta-Analysis as Topic

Humans ; Orthodontic Appliances ; Sleep Apnea, Obstructive ; therapy

The aim of the present study was to evaluate the protective effect of catalpol on vascular endothelial function in STZ-induced type 2 diabetes mellitus (T2DM) rats. 40 high-fat diet with STZ-induced diabetes rats were randomly divided into model group, catalpol low-dose, middle-dose and high-dose group (10, 50, 100 mg x kg(-1) x d(-1)), 10 normal Wistar rats were used as the normal group. The normal and model groups were given an equivalent amount of saline. All reagents were administered by oral gavage for 6 weeks. After 6 weeks, blood glucose and lipids were detected by an automatic biochemical analyzer. The endothelium-dependent vasodilation response of thoracic aortar was detected. The pathological changes of the thoracic aorta were observed by HE staining. Ser- um nitric oxide (NO), 8-iso prostaglandin F2α (8-iso-PGF2α) and superoxide dismutase (SOD) were detected by ELISA. Reactive oxygen species (ROS) level of thoracic aorta was detected by fluorescence method. The expression of Nox4 and p22phox mRNA and protein in aortic tissue were detected by RT-PCR and Western-blot respectively. After catalpol treatment, endothelial damage of thoracic aorta was attenuated significantly; ROS level of thoracic aorta and serum level of 8-iso-PGF2α were decreased significantly; serum NO and SOD levels were remarkably elevated; expression of Nox4, p22phox mRNA and protein in thoracic aorta were significantly reduced (P < 0.05). Therefore, catalpol has protective effect on endothelial of T2DM, its mechanism may be associated with the down-regulation of Nox4 and p22phox expression, inhibiting oxidative stress reaction response.
Animals ; Blood Glucose ; metabolism ; Diabetes Mellitus, Experimental ; pathology ; Diabetes Mellitus, Type 2 ; pathology ; Dinoprost ; analogs & derivatives ; metabolism ; Endothelium, Vascular ; drug effects ; metabolism ; pathology ; Enzyme Inhibitors ; pharmacology ; Gene Expression Regulation ; drug effects ; Iridoid Glucosides ; pharmacology ; Male ; NADPH Oxidase 4 ; NADPH Oxidases ; antagonists & inhibitors ; genetics ; metabolism ; Nitric Oxide ; metabolism ; RNA, Messenger ; genetics ; metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species ; metabolism ; Superoxide Dismutase ; metabolism

The initial definition of stress and its development were briefly retrospected with elucidating the significance of stress in life sciences study. Stress is involved in a variety of physiological and pathophysiological processes. Description of the advances focusing on the relationships between stress and several body systems including nervous system, immune system and cardiovascular system etc. and on the stress molecules and signal transduction was carried out. The ultimate aim of the review is to emphasize the importance and the distinct position of stress during the development of modern bio-medicine, and to further attract more attention to the research field of stress from more scientists.

Studies have shown that embryonic stem cells and neural stem ceils could be induced to differentiate into motor neurons by adding inducing factors to the culture to improve differentiation proportion of motor neurons. The development and maturation process of motor neurons in vitro culture is similar to that in embryo, involving participation of Pax6, Nk×6.1, Olig2 and HB9. Moreover, cells with HB9 as separation mark almost differentiate into motor neurons in vitro. In addition, other types of protein marks have been used for identification of motor neuronal induced differentiation, such as neuron mark MAP-2, β-tubulin-Ⅲ, cholinergic cell mark ChAT, VAChT, Schwann cell mitogen REG2, and voltage-dependent calcium ion channel 11.2 subunit. The identification of induced differentiation of motor neurons also involves detection of function of differentiated motor neurons by two methods. One method is to detect the function of in vitro cultured motor neurons, and the other is to detect the function of transplanted motor neurons in vivo. Although induced differentiation of stem cells into motor neurons becomes mature, many issues remain in clinical application, such as cell sources of induced differentiation of motor neuron, efficiency of induced differentiation, purification of differentiated motor neurons, and function of motor neurons.

Objective To observe the mini -invasive treatment for patients with medium volume of hyper-tensive criatocapsular hemorrhage.Methods 59 patients with medium volume of hypertensive criatocapsular hemor-rhage(20 -30mL)were selected and randomly divided into mini -invsasive surgery group and conservative treatment group.Two groups were compared the average length of stay,hospital costs and clinical effect.Results The avergae hospital stay (14 ±3.26)days and avergae cost (1.1 ±0.33)ten thousand yuan of the mini -invsasive surgery group was lower than those of the conservative treatment group (25 ±6.58)days and (1.8 ±0.56)ten thousand yuan],the differences were statistically significant (t =7.999,5.768,all P <0.01).After 3 months follow -up,the recovery of self -care ability after operation estimated by ADL scores in the mini -invsasive surgery group was significantly better than that in the conservative treatment group(12 /31 vs.25 /28,χ2 =16.093,P <0.01).Conclusion For patients with medium volume of hypertensive criatocapsular hemorrhage(20 -30mL),minimally invasive surgery can shorten hospital stay,reduce the financial burden of patients,and improve the prognosis significantly.