Objective To Investigate the effect of Interleukin-15 on guinea pigs cholecystitis formation.MethodsCholecystitis models on guinea pigs were established.Then the content of IL-15 in the serum and bile was measured with ELISA method.ResultsThe content of IL-15 in the serum and bile significantly was elevated,and a remarkable difference was existed between the experimental group and blank control group.In addition,in the cholecystitis models group,IL-15 content in the serum and in gallbladder bile showed significantly positive correlation.ConclusionIL-15 participates in the formation of cholecystitis.

Objective To investigate the effect of spontaneous urination training on postoperative urine retention and catheteration duration of cervical cancer patients. Methods Seventy patients were divided into the control group (n=34) and control group(n=36). according to the admission time Both groups received bladder function training. Besides this, the control group also received intermittent clamping of urine catheter while the observation group received spontaneous urination training . The two groups were compared in terms of incidence of urinary retention and catheteration duration. Result The incidence of urinary retention in the observation group was lower than that of the control group, there was significant difference between the this groups (P<0.05). Conclusion For the patients after cervical cancer operation , both bladder function training and urination training can reduce the incidence of urine retention .

Objective To explore the short-and mid-term curative effect and influence factors of hepaticojejunostomy(Kasai operation) for biliary atresia.Methods The clinical data of 66 children with biliary atresia treated with Kasai operation were analyzed retrospectively.The jaundice fading rate,2-year survival rate and influence factors of prognostic were analyzed.Results The jaundice fading rate of 62 cases was 58.1％ after Kasai operatiou.The patients also had a 2-year native liver survival rate of 53.2％.The jaundice fading rate,2-year survival rate of type Ⅰ,Ⅱ and Ⅲ had no significant differences (χ2 =1.91,0.76,all P ＞ 0.05).The 2-year survival rate of children underwent Kasai operation as younger than 60 days was higher rate than that of the children as 61 to 90 days and older than 90 days(χ2 =4.72,P ＜ 0.05).The 2-year survival rate of children with cytoinegalovirus infection and postoperative cholangitis were 43.6％,39.5％,respectively,which were lower than those of children without cytomegalovirus infection and postoperative cholangitis (69.6％.75.0％) (χ2 =3.92,7.46,all P ＜ 0.05).Conclusion Kasai operation is still the preferred method for the treatinent of biliary atresia.Type of the disease was not related with the short-and mid-term effects of Kasai operation.Age at operation was the main factor affecting the prognosis.Therefore,it is very important to make early surgery,enhance the anti-viral treatment and prevent postoperative cholangitis.

Objective　To analyze the partial correlation problems by multilevel bivariate models.Methods　Multilevel bivariate models.Results　The results of correlation analysis with multilevel bivariate models is same with traditional methods,but the former is more quick and simple.Conclusion　Multilevel bivariate models are effective methods in analyzing the partial correlation problems.

Objective To investigate the effect of the extent of surgical resection on the prognosis of children patients with advanced neuroblastoma. Methods Thirty-seven children patients with advanced neuroblastoma were selected as our subjects,who underwent surgical treatment in the People's Hospital Binzhou from Jan. 2001to Dec. 2006. All the patients were treated with surgical operation or surgical operation combined with chemotherapy,among them 24 cases were completely removal,and 13 cases were partially removal. All patients were followed-up for more than 5 years. Log rank test and multivariate COX regression analysis were used to explore the effect of surgery resection on prognosis. Results The influencing factors of the complete resection group included lymphatic metastasis,clinical stage,combined with chemotherapy,tumor markers neuronspecific enolase(P = 0. 002,0. 000,0. 019,0. 015 respectively). COX regression analysis showed that the independent factors included chemotherapy( OR = 1. 952,95% CI = 1. 258 - 2. 759,P = 0. 000),lymph node metastasis(OR = 2. 856,95% CI = 1. 356 - 3. 859,P = 0. 019),and extent of surgical resection(OR = 3. 069, 95% CI = 1. 585 - 4. 685,P = 0. 005). The shortest survival period of patients in this study was a month,and the median survival period was 33. 96 months. One year survival rate was 62. 21% and 2-year survival rate was 41. 09% as well as 3-year survival rate was 23. 59% . The average survival period between total and partial of surgical resection was significant((56. 96 ± 13. 22)months,(19. 63 ± 10. 20)months;P = 0. 019). Conclusion Surgical resection is an important factor of the prognosis of patients with NB. If the patient's own conditions permit,it can be appropriate to expand the scope of surgical resection in order to reduce the risk of tumor recurrence.

Objective For decreasing the mistreatment and the excess treatment of Chlamydia trachomatis pneumonia,this article analyze Chlamydia trachomatis pneumonia clinic features in the infant.Methods Making review analysis to the clinic data of 64 infant age of 0 to 3 months old suffering from Chlamydia trachomatis pneumonia.Results The infection history of these babies is not identify in their perinatal period.The average age when they were ill is 32.77?19.03d;It happened more frequently in spring and winter.The patient's condition is gently with cough as their feature,following fever,gasping,fine crackles,or none of those.It does not prolong the course of disease by following the air tube virtue infection.The increase of the Blood white cell is 43.8% and that of the neutrophile is less than 20%.The level of Few CRP increase.The abnormal of the baenosome X-ray is on both sides.It can relieve symptom and physical sign,and shorten the time in hospital for using the macrolide medicine,and it surpass the cephalosporin.Conclusions The Chlamydia trachomatis infection does not result in the damage of the organ,even if jeopardizing the life.It is helpful to recognize the clinical course correctly for the analysis of the complicated clinical condition exactly.

Schizophrenia is roughly equivalent to insanity in TCM.Premorbid personality traits of schizophrenia are similar to the characteristic of stagnation of liver in TCM.The stagnation of liver-qi is a usually cause and main differentiation type of schizophrenia.Early location of this disease is toward to the liver.The stagnant qi of the liver turns into fire,up to brain to interfere the activity of mind,then leads the disease into the acute phase;Stagnation of the liver-qi and the heart-fire affect other organs and lead the disease to its chronic phase:The change of solar term or dramatic disturbances of climate change often leads liver yang to interfere the mind,resulting in recurrence or relapses of schizophrenia.We should pay attention to rule of liver in the treatment,rehabilitation,prevention of recurrence in schizophrenia.When treating schizophrenia,we need pay attention to soothing liver,without inhibiting the sthenic liver-energy;suppressing the hyperactive liver by calming the liver and removing heat from the liver.Soothing liver and strengthening spleen,dispersing liver-qi and regulating stomach are the common treatment.For preventing degeneration,while nourishing liver and kidney,clearing heat and calming the mind should be used at same time;while nourishing liver yin,wind-dispersing,eliminating phlegm,clearing-stasis should be used at same time.Cleaning liver heat,nourishing yin,activating blood and detoxification should be paid attention to when preventing and treating the side effects caused by antipsychotic drugs.

Objective To investigate the action and the mechanism of Jinyin granule(JYG) on cholecystitis in guinea pigs.Methods Cholecystitis models of Guinea pigs were established and then randomly divided into six groups: normal group,model group,XiaoYanLiDan tablet(XYLDT) group,treatment groups including low,middle and high dosage groups of JYG.The Pigs were given above drugs respectively while in normal and model groups the same volume of normal saline was given.Body weight,gallbladder weight,bile amount,IL-1? in the serum were measured and gallbladder pathological tissue was observed by light microscopy.Results Comparing with the model group,the treatment groups had higher body weight,lower gallbladder weight,less bile amount,obviously slighter inflammation and less amount of IL-1? in the serum.Conclusion JYG possesses the therapeutic action to cholecystitis on guinea pigs and its mechanism is interrelated to the decreasing of IL-1? in the serum.

Objective To study the clinical characteristics of necrotizing enterocolitis(NEC) in premature neonates. Methods Twenty eight premature and 35 full term neonates with NEC in our hospital from 1994 to 2003 were enrolled in this retrospective study. The clinical manifestation, X ray and laboratory results were analyzed. Results The presentations of premature group were more severe than that of the full term group,such as poor perfusion (54% vs 26%, P

Objective To understand the iodine nutritional status of urban and rural pregnant women in Shijiazhuang.Methods Urban pregnant women were selected from 8 neighborhood committees of Chang' an District,Shijiazhuang,while the rural pregnant women were selected from 72 villages of 18 counties in Shijiazhuang.These research subjects were grouped into women with early pregnancy at 1-12 weeks,mid pregnancy at 13-28 weeks and third trimester at 32-40 weeks.Urine samples of the subjects were collected.Arsenic-cerium catalytic spectrophotometry (WS/T 107-2006) was used to determine urinary iodine concentrations (UIC).Results Seven hundred thirty-seven urban pregnant women and 898 cases from the rural areas,totally 1 635 subjects were included into the survey.The median UIC of urban subjects,rural cases,and all pregnant women in Shijiazhuang was 169.0,145.9 and 156.7 μg/L,respectively.The median UIC of the rural pregnant women was significantly lower than that of their urban peers (x2 =54.569,P ＜ 0.05).Urban pregnant women with UIC less than 150 μg/L accounted for 40.30％ (297/737) of the total cases,and rural pregnant women 51.89％ (466/898).The difference was statistically significant between these subjects (x2 =21.864,P ＜ 0.05).The median UIC of pregnant women at third trimester of the urban and the rural areas was 113.5 and 145.6 μg/L,respectively.Though their UICs were not up to the national criteria (150 μg/L),the difference was statistically significant between the urban and the rural subjects (x2 =8.365,P ＜ 0.05).UIC less than 150 μg/L of the urban and the rural pregnant women [60.19％ (65/108) vs 51.96％ (93/179)]at third trimester was not significantly different (x2 =1.844,P ＞ 0.05).Conclusions Iodine deficiency is present in pregnant women in Shijiazhuang City.Iodine deficiency among rural pregnant is more severe than that of peers of urban.The iodine deficiency is more severe in the pregnant population at late pregnancy.Besides iodized salt,food with rich iodine should be supplemented for the pregnant,especially those at the third trimester.It is important to monitor iodine nutritional status dynamically during the pregnancy to keep a proper UIC for the pregnant.