Objective To summarize the clinical and pathogenic characteristics of urinary tract infection(UTI)in infants,and to provide reference for clinical diagnosis and treatment.Methods One hundred and eighty-eight cases of hospitalized infants with UTI diagnosis standard in Department of Pediatric Renal Rheumatism Immunology,Shengjing Hospital Affiliated to China Medical University from January 2012 to January 2015 were collected,and on the basis of the imaging they were divided into complex group(complicated UTIs) and non-complex group(non-complicated UTIs),the differences between 2 groups in the general condition,clinical manifestations,serological examination,urine culture and distribution of pathogenic bacteria and drug sensitivity results were analyzed.Results Among 188 UTI infants,148 were male and 40 were female,50 cases were in complex group (26.6％),and 138 cases were in non-complex group (73.4％).In complex group,the prevalence of prenatal ultrasound abnormalities (34.0％),the incidence of recurrent infections(24.0％),the number of fever incidence(78.0％),and peripheral WBC count [(16.4 ± 4.3) × 109/L] were higher than those in non-complex group[1.5％,10.9％,58.7％,(14.6 ± 3.5) × 109/L] (all P ＜ 0.05),and the naked eye hematuria incidence was lower than that of the non-complex group (14.0％ vs 34.8％,P =0.006).In complex group,pneumonia klebsiella bacteria positive rate was higher than that of non-complex group (22.0％ vs 2.9％,P =0.000),and the positive rate of Escherichia coli was lower than that of non-complex group(26.0％ vs 46.4％,P =0.000).There was no difference in the drug sensitivity and resistance of the pathogenic bacteria in the urine culture of 2 groups.Conclusions For fever,increased peripheral WBC,repeated infection and urine culture for Klebsiella pneumoniae UTI infants,in particular,should be alert to the prese-nce of urinary tract abnormalities,timely improve the urinary system ultrasound and urinary tract contrast is very necessary.

Colorectal cancer (CRC),a common gastrointestinal malignancy,has been a threat to the health and life of human being.CRC is concealed with no obvious clinical symptoms or signs.Therefore,most of the patients have been in the middle and advanced stage when CRC has been diagnosed.Thus it seriously affects the prognosis and life.Accordingly,early diagnosis is crucial in earlier treating,prognosis improving and survivability increasing.In recent years,the morbidity and mortality of CRC are still on the rise.Hence,how to improve the early diagnosis rate has been a research focus in clinical study.Based on this point,the author makes a literature review on the early diagnosis of CRC.

Thetherapeuticeffectsofintermitentcyclicetidronatedisodium(HEBP)ofdifferentdosesonovariectomy-inducedosteoporosiswerestudied.53femaleWistarrats,weighingwithanaver-ageof266gmwererandomlydividedinto5groups.Gourp1hadbilateralovariectomy(OVX)andwasgivenlowdoseHEBPof25mg/kgBW/day;group2hadOVXandgivenmediumdoseHEBPof36mg/kgBW/day;group3hadOVXandgivenhighdoseHEBPof51mg/kgBW/day;group4hadOVXandgroup5hadshamOVX.HEBPwasadministratedoralyduringfastingfor5daysfolowedbyarestperiodof25daysandtheregimewasrepeatedfor3times.Alanimalsweresacrificedat90thdayafterOVX.RadioimmunoassayofserumestradiolconfirmedthesuccessofOVX.TheserumCaandPcon-tent,AKPaseactivity,femoralrelativedryweight,CaandPcontentwereanalysedrespectively.Therighttibiaewereprocessedundecalcifiedforquantitativebonehistomorphometry.TheresultsshowedthatthebonecalciumcontentandtrabecularbonevolumeofOVX-ratstreatedwithHEBP,especialywiththelowdosegroupwerehigherthanthatofthesimplyOVX-ratandtheboneturnoverparameterssuchasAKPaseactivity,boneformationsurface,boneresorptionsurface,activeformationsurface,bonemineralappositionrateandboneformationratewerelowerthanthoseofthesimplyOVX-rat.TheresultsindicatetheHEBPcouldretardthedegreeofosteopososisthroughreducingtheelevatedboneresorptionandboneturnoverinducedbyOVX.Meanwhile,theresultssuggestthattheefectoflowdoseHEBP(25mg/kgBW/day)wasmoreefectivethanthatofthehighdose.

Objective To summarize our clinical experience of prophylaxis and treatment for complications associated with catheterization of brachial artery. Methods 87 patients underwent endovascular treatment via brachial artery. Complications associated with catheterization of brachial artery were retrospectively analyzed. Results Under ultrasonic guidance the catheterization procedure of brachial artery was successful in all 87 patients. The success rate of cannulation was 100%. In 53 patients(61% ) ultrasonic guided cannulation was successful at the first attempt, the other 35 (39% ) with 2 or more than 2 times puncture. Complications associated with catheterization of brachial artery were detected in 16 cases. The complication rate was 18. 4%. Guidewire insertion into peri vascular compartment took place in 4 cases (4. 6% ). Episodes of local hematomas were noted in 11 cases( 12. 6% ) and in three of the 11 cases nerve injuries were detected (one of which was of late-onset type). Brachial artery pseudoaneurysm was found in 1 case(1.2%). Conclusion Familiarity with the anatomical features of the brachial access, skillful application of the techniques for the catheterization, full understanding of complications and sufficient preparation of treatment strategies can prevent those complications effectively.

Aim To investigate the clinical importance of a newly designed tenodesis with polymolecular polyethlene fastener. Methods Eighty-nine patients with knee ligaments injuries were reconstructed with the technique of newly designed tenodesis. Rehabilitation program started under the instruction of the therapist from the next day of the surgery.Results The tenodesis on all patients in our study were successful. The fasteners in two patients and the transplants in three patients were blocked in the bone tunnel during the operation. One fastener was taken out from the bone tunnel under arthroscopy. The patients were followed up for 19 months averagely (from 6 months to 49 months), most of them showed a stable knee without complain, except two patients feel uncomfortable after vigorous activities; seven patients show little laxity in anterior drawer test (ADT) or posterior drawer test (PDT) and three patients had 20-degree limitation of knee flexion. Lysholm scale score were 56?8 and 89?5 before and after operation, respectively ( P

Objective To study the antitumor activity of betaine and its effect on the glycometabolism of S_(180) bearing mice. Methods On the basis of S_(180) bearing mice, taking tumor inhibition rate, the activity of LDH and ALD in serum as indexes which were determined by test kits. Results The different dosages for tumor inhibition rate of betaine are 39.8%, 25.7%, and 17.7%, respectively, betaine of high dosage can remarkably decrease the activity of LDH, and ALD (P

OBJECTIVE To explore the disinfection methods for slippers that used in operation room. METHODS A total of 120 pairs of slippers were monitored on their disinfection half of them were with automatic washer machine as a test group; while control group was dealed mannally with compound chlorine disinfection solution. The disinfection effects of two groups were compared. RESULTS The disinfection effects of two methods were identical, but had a difference of work efficiency. CONCLUSIONS The slippers used in operating room are contaminated by bacteria seriously. The manual disinfection method is low inefficient. The test group by machine method is with good efficiency and safety, so, it was recommendable for clinical use.

Objective To investigate the expression and the significance of AQP2 in the kidneys of septic rats. Methods Sixty-four Wistar rats of 6 weeks were randomly divided into two groups: sham group and the septic model group. Septic models were made by cecum ligation perforation (CLP). Fach group was divided into 3-hour,6-hour,12-hour and 24-hour subgroups,with 8 rats in each. The urine,blood and kidney sampies were collected. The urine volume ,urine osmotic pressure and renal function were observed. The expressions of AQP2 protein in rats' kidneys were determined by using immunohistochemical method and the expressions of AQP2 mRNA with real-time PCR. The pathological changes of the kidneys were observed under light microscopy. Results After CLP,urea volume of Wistar rats in septic model group decreased and urine osmotic pressure increased at 3 hours; urea volume gradually increased and urine osmotic pressure decreased at 6 hours; Serum Cr and urea nitrogen began to increase at 6 hours and reached the peak at 24 hours. The longer the time lasted after CLP,the more serious the injury of kidney became,which was mainly manifested as that the space between the epithelial cells of the tubular wall disappeared,nucleus disappeared,glomerular loops fused,and cell structure was unclear. Renal mesenchymal was infiltrated with inflammatory cells. AQP2 mRNA expression increased at 3 hours,decreased at 12 hours and 24 hours ,AQP2 protein expression decreased at 12 hours,with the lowest at 24 hours,which were significantly different from those of the sham groups(P<0.05). Conclusion AQP2 may regulate the water metabolism of septic rats' kidney. The decreased AQP2 protein expression is one of the main pathological mechanisms that results in dysfunction of urine concentration in sepsis.

Ischemia-reperfusion injury (IR) refers to the ischemic tissues or organs to regain perfusion on tissue and organ damage.The reactive oxygen species(ROS)generated by the mitochondrial and the change of the mitochondrial permeability can be induced mitophagy.And dysfunction of the mitophagy is closely related to the body a variety of disease.This article aims to introduce the research of progress about mitophagy in recent years,especially the role it play in the ischemia-reperfusion injury.