Sepsis is a major cause of mortality among children and newborns.The largest part of the global pediatric sepsis burden occurs in middle-and low-income countries,where the mortality of sepsis reaches 24％-50％.It is necessary to provide clinicians with a framework to improve the management of pediatric septic patients.The key of treatment is to ensure adequate tissue perfusion,to maintain cardiovascular and hemodynamic stability,the administration of adequate antibiotics,the proper use of glucocorticoid,and so on.

Objective:To investigate the effect of IRH on pulmonary fibrosis and its intervention mechanism.Methods:45 sprague-dawley rats were randomly divided into three groups.The model group and the intervention group were received endotracheal injection of bleomycln to induce pulmonary fibrosis,while the control group were received endotracheal injection of saline.From the second day the intervention group IRH were injected to the stomach,while the other two groups were injected saline instead.On the 7th day,14th day and 28th day the lungs were isolated.The expression of MMP-2 and TIMP-1 was detected by immunohistochemical method respectively.Results:There was only a very weak expression of MMP-2 and TIMP-1 in the control group,there was significantly higher level in model group compared with control group on the 7th day,14th day and 28th day.The IRH group was significantly lower than the model group with the same time points,though it was also obviously higher than the control group all over the period(P

Objective To observe the curative effect of acupuncture point bloodletting,flash tank combined with ultrashort wave auxiliary in the treatment of infantile cough.Methods 102 children with cough were selected and randomly divided into control group (50 cases)and observation group (52 cases).The control group adopted general anti -infection,reduce phlegm,the method of atomizing inhalation.The observation group received control method based on the acupuncture point thorn bloodletting,cans,combined with ultrashort wave.The clinical curative effect was compared in the two groups.Results In the treatment group,34 cases got cure,improvement in 17 cases, 1 case had no effect,the cure rate was 65.3%,total effective rate was 98.0%,without efficiency 1.9%.In the control group,18 cases got cure,improvement in 23 cases,9 cases of invalid,and the cure rate was 36.0%,the total effective rate was 82.0%,without efficiency was 18.0%.The total effective rate between the two groups had statistically significant difference (χ2 =4.105,P <0.05).Conclusion Acupuncture point bloodletting,flash tank combined with ultrashort wave auxiliary in the treatment of infantile cough can obviously improve the clinical effect.

Fractal is a new conception.In this paper some knowledge of fractal is first described.Our research work of fractal application in Doppler ultrasound technique is reported.

High-frequency ventilation ( HFV) is theoretically an ideal ventilatory mode for lung pro-tection. It also delivers extremely small tidal volumes near to or less than the anatomically invalid cavity (about 2ml/kg) at very high respiratory frequencies (recognized ventilation frequency about 4 times more than the normal range) . Compared to the conventional mechanical ventilation,HFV makes use of lung-open mode,with low tidal volume, low airway pressure, low thoracic pressure and end-exhaling pressure effect, which can avoid recruitment/derecruitment of alveoli to reduce pressure injuries on lung tissue and airway. Nowadays,more and more critical care practitioners implement this ventilation mode. We reviewed the princi-ples,classification,parameters,and clinical indications of HFV in this article.

Objective: To explore the clinical effect of modified preflush on the treatment of CRRT without heparin in patients received dialysis with complication of cerebral hemorrhage. Methods: 44 patients received dialysis with complication of cerebral hemorrhage were divided into control group (28 cases) and observation group (16 cases) according to the implemented time of modified preflush. A retrospective analysis was adopted to compare the effect of filter in blood coagulation grade and service life between conventional preflush (control group)and modified preflush (observation group). Results: The differences of I, II, III grade of blood coagulation between the two methods were significant (x2=12.020, P<0.05), and the differences of average service time of filter, transmembrane pressure(TMP), pressure of filter and value of pressure drawdown (ΔP) between the two methods also were significant (t=3.535, t=4.024, t=6.071, t=3.524, P<0.01). Besides, the difference of venous pressure (PV) between them was significant (t=2.166, P<0.05), while the differences of BFR, UFR and Pa between the two methods were not significant (t=0.263, t=1.162, t=0.258, P>0.05). Conclusion: Modified preflush method can make the fiber of filter to obtain more full stretch and soak, and it also can prolong the service of time, and decrease incidence of blood coagulation, and ensure curative effect and smooth process.

Objective To explore the application of partial least square regression model in the study of personality characteristics of the scientific personne1,to supply more reliable and scientific rationale to the training and intelligent use of scientific personne1 in colleges.Methods We took our survey by 114 scientific personnel from eight universities with NEO-PI-R(Revised NEO Personality Inventory).After the process of simplifying the NEO-PI-R,we need partial least square regression model to analyze.Results The results of the PLS analysis indicates the goodness-of-fit of the model was good,which opened out clearly and intuitively the connection between the items and five personality characteristics,the model could be used as theory reference for personnel department,research department and education department to consummate the training of scientific personne1 in colleges.Conclusion Partial least square regression model could be used to study personality characteristics of the scientific personne1 in colleges as statistic method appearing recently.

Objective To increase the speed of thermoacoustic imaging, a deconvolution reconstruction (DR) algorithm is proposed for small-scale need detecting living beings, on the basis of deconvolution of thermoacustic imaging algorithm. Methods A new function was firstly constructed from the detected acoustic pressure function. Then, the distribution of electromagnetic wave absorption coefficient of the need detecting living beings could be reconstructed from this new function based on the deconvolution method. Computer simulation studies were carried out to compare the DR algorithm with the two popular algorithms: the time-domain reconstruction (TDR) and the filtered back projection (FBP). Results For small-scale need detecting living beings, the accuracy of DR was nearly equivalent to TDR and slightly better than FBP. However, DR was about 4 to 6 times faster than TDR and about 25 to 100 times faster than FBP under the simulation experiment condition. Conclusion DR is a fast and effective algorithm of thermoacoustic imaging for small-scale living beings.

Objective To study the method based on gradient vector flow (GVF) and particle swarm optimization (PSO) for realizing multimodal medical image registration and improving its accuracy. Methods In view of three major components of image registration, i.e. the feature space, the similarity metric and the search strategy, a novel method was proposed with three improvements. Firstly, the GVF field was employed as the feature space. Then three similarity metrics were proposed based on GVF field. Finally, an improved PSO combined with crossover mechanism of genetic algorithm was utilized to search for the optimal transformation of two images. Results With 54 times of experiments on both simulated and real medical images, it was demonstrated that this method accurately registered the multimodal medical images to be superior to the method based on PSO of pixels, and the Walsh transform method. Conclusion The method based on GVF and PSO is effective for multimodal medical image registration.

Objective: To investigate the effect of different analgesia methods on blood coagulation in patients who underwent esophageal carcinoma surgery through thrombelastography (TEG). Methods:A total of 60 patients who underwent radical esophagecto-my were randomly divided into the patient-controlled epidural analgesia (PCEA) group and patient-controlled intravenous analgesia (PCIA) group with 30 cases each. The visual analogue scale (VAS) and patient-controlled analgesia (PCA) bottom pressing times were recorded at 6, 12, 24, and 48 h after surgery. The TEG parameters were measured at the time before anesthesia (T0), the end of surgery (T1), first day after operation (T2), second day after operation (T3), and third day after operation (T4). Results:(1) Compared with the PCIA group, the VAS scores and PCA bottom pressing times were significantly lower (P<0.05). (2) The R and K values of the PCEA group had no significant difference compared with T0 (P>0.05), and were significantly prolonged than those in the PCIA group at T2, T3, and T4 (P<0.05). (3) The platelet amount of the two groups decreased at T2 and T3 compared with that at T0 (P<0.05). Conclu-sion:The analgesic effect of PCEA was better than that of PCIA in patients who underwent esophageal carcinoma surgery, and may im-prove their hypercoagulability.