Apollon is a member of inhibitor of apoptosis proteins. It can inhibit apoptosis through inter-action with Smac, HtrA2 and caspase. Apollon is highly expressed in a variety of tumors, such as leukemia, breast cancer, brain cancer, carcinoma of mouth and carcinoma of stomach. Apollon may relate with genesis and prognosis of tumor . It also may lead to drug resistance of certain tumors.

HOXA9 is a member of homeobox gene,and more commonly expressed in leukemia cells,which may be involved in the development and progress of leukemia with Meisl, PBX1 and Trib2. HOXA9 also affects the treatment outcome and prognosis of leukemia, the higher the expression level, the poorer response to treatment, the prognosis is also poor.

Objective To evaluate the value of Binax NOW pneumococcal antigen test for rapid diagnosis in patients with purulent meningitis.Methods Cerebrospinal fluid (CSF) were collected prospectively from 86 children who were diagnosed with purulent meningitis in the Department of Infectious Diseases at Beijing Children′s Hospital from March 2013 to March 2014 and were tested by Binax NOW method.CSF culture was considered as golden standard to evaluate the sensitivity and specificity of the Binax NOW method.Continuous variables were compared with t test, categorical variables were compared with χ2 test.Results Among 86 cases of purulent meningitis, 34 (39.5%) had positive culture and 21 (24.4%) were Streptococcus pneumonia, while 31 (36.0%) were positive by Binax NOW test.Using CSF culture as golden standard, the sensitivity and specificity of Binax NOW for diagnosis of pneumococcal meningitis were 90.5% (19/21) and 81.5% (53/65), respectively.Conclusion Binax NOW pneumoniae antigen test in CSF yields high sensitivity and specificity, which is useful in clinical application and enables prompt and adequate treatment.

Objective To explore intelligence impairment in the patients with idiopathic parkinson's disease(PD) and to investigate whether auditory P300(P3) can be influenced by levodopa therapy. Methods The standard auditory P300 were measured before starting treatment and 6 months after starting treatment in 30 patients with idiopathic parkinson's disease, and 30 healthy subjects with matching age, sex and education levels served as control. Results After levodopa treatment in patients with PD, P300 latency(PL) and amplitude(Amp) did not significantly changes, but reaction time (RT) was significantly shortened(P

OBJECTIVETo explor the curative effect of double pedicle sliding skin flap for correction of cryptotia.

METHODSFrom January 2011 to October 2014, 7 cases with cryptotia (12 ears) were treated. We designed a double pedicle sliding skin flap above the helix. The flap was slided downward to form a new auriculocephalic sulcus. The other wound was covered by skin graft.

RESULTSAll wounds healed very well with no complication. The follow-up period ranged from 3 months to 1 year, with an average of (5.67 ± 3.38) months. The ear had stable appearance with no recurrence. The result was satisfactory.

CONCLUSIONSThe method is simple with reliable flap survival rates. The new auriculocephalic sulcus is stable and resistant. It's a good choice for correction of cryptotia.

Ear Auricle ; abnormalities ; surgery ; Ear Cartilage ; abnormalities ; surgery ; Follow-Up Studies ; Graft Survival ; Humans ; Reconstructive Surgical Procedures ; methods ; Surgical Flaps ; transplantation ; Time Factors ; Wound Healing

Objective To investigate the changes in bone age, and the correlation between the changes in structure and function of cardiovascular and bone age index in children with left to right shunt congenital heart disease (CHD) such as atrial septal defect (ASD), ventricular septal defect (VSD) and patent ductus arteriosus (PDA). Methods One hundred and thirty children diagnosed CHD had been enrolled, including 52 cases of ASD, 46 cases of VSD and 32 cases of PDA. The cardiac structure and function indicators had been detected by ultrasonic. The anteroposterior iflm of left hand and wrist had been taken. The bone age had been assessed according to“China children bone age score”atlas, and the bone age index (BAI) had been calculated. The differences of bone age among each group had been compared. The linear correlation of the cardiac structure and function indicators with BAI had been analyzed. Results The BAI was statistically different among ASD, VSD and PDA groups (P<0.05). The BAI of PDA group was higher than those of ASD and VSD groups (all P<0.05). The BAI was also statistically different among the groups with different pulmonary artery pressures (P=0.000). The BAI was higher in small defect size group than that in large defect size group (P=0.002). The defect size was negatively correlated with BAI in both ASD and VSD groups (r=-0.48, -0.54, all P<0.05), The pulmonary artery systolic pressure and pulmonary-to-systemic blood lfow ratio (QP/QS) were negatively correlated with BAI in ASD, VSD and PDA groups (r=-0.64--0.38,all P<0.05). Conclusion The bone age and BAI of children with left to right shunt CHD are signiifcantly lower than those of healthy children of the same age . The extent of bone age delay is related with PASP, defect size and shunt volume in children with left to right shunt CHD.

Objective To explore the clinical significance of plasma D-dimer and fibrinogen level in cervical carcinoma . Methods Sxity-two patients with cervical cancer pathologically proved ,34 cases of benign uterine tumors and 42 cases of CIN were detected plasma DD and Fib levels preoperative , compared with normal control group .Results DD and Fib levels in patients with cervical cancer group were significantly higher than those of control group;With the lesions of cervical cancer malignant degree of plas-ma DD and Fib levels increased;DD and Fib increased cervical cancer occur more frequently in patients with lymph node and distant metastasis .Conclusions Along with the increase of the malignant degree of tumor ,Micro thrombosis or thromboembolism risk increa-ses,In clinical,they can be used as auxiliary index to predict clinical cancer staging and transfer .

Objective: To investigate the effect of different analgesia methods on blood coagulation in patients who underwent esophageal carcinoma surgery through thrombelastography (TEG). Methods:A total of 60 patients who underwent radical esophagecto-my were randomly divided into the patient-controlled epidural analgesia (PCEA) group and patient-controlled intravenous analgesia (PCIA) group with 30 cases each. The visual analogue scale (VAS) and patient-controlled analgesia (PCA) bottom pressing times were recorded at 6, 12, 24, and 48 h after surgery. The TEG parameters were measured at the time before anesthesia (T0), the end of surgery (T1), first day after operation (T2), second day after operation (T3), and third day after operation (T4). Results:(1) Compared with the PCIA group, the VAS scores and PCA bottom pressing times were significantly lower (P<0.05). (2) The R and K values of the PCEA group had no significant difference compared with T0 (P>0.05), and were significantly prolonged than those in the PCIA group at T2, T3, and T4 (P<0.05). (3) The platelet amount of the two groups decreased at T2 and T3 compared with that at T0 (P<0.05). Conclu-sion:The analgesic effect of PCEA was better than that of PCIA in patients who underwent esophageal carcinoma surgery, and may im-prove their hypercoagulability.

Objective To investigate the correlation between macular structural changes and functional outcomes in idiopathic macular epiretinal membranes (IMEM).Methods Clinical data of 85 patients with monocular IMEM admitted from April 2013 to April 2014 were retrospectively analyzed.The diseased eyes(85 eyes)were studied as observation group and the normal eyes (85 eyes)served as control group.The results of routine eye examinations,optical coherence tomography (OCT) and multifocal electroretinography (mfERG) were compared between observation and control groups.Results The preoperative best corrected visual acuity (BCVA) in observation group was lower than that in control group (0.55-± 0.17 vs.0.92 ± 0.14,P ＜ 0.05);the eyes with BCVA ＜ 0.1 in observation group were more than those in control group (P ＜ 0.05).The central retinal thickness (CRT) of observation group was higher than that of control group[(322.1 ±54.3) μm vs.(210.3 ±47.5) μm,t =14.29,P ＜0.05].The average response density of N1 wave and P1 wave in observation group were (36.7 ± 19.7) and (95.2 ±24.0) nV/ deg2,which were lower than those in control group [(42.9 ± 16.3) and (134.8 ± 20.1) nV/deg2;t =-2.23 and-11.66,respectively,P ＜0.05].The latent period of N1 wave and P1 wave in observation group were (22.0 ±4.1) and (39.5 ± 4.7) ms,which were lower than those in control group [(18.7 ± 3.0) and (38.0 ± 3.2) ms;t =5.99 and 2.43,respectively,all P ＜ 0.05].The CRT in observation group was not correlated with average response density of macular center N1,P1 wave and latent period (r =-0.23,-0.35,0.06,-0.04,all P ＞ 0.05).BCVA in observation group was negatively correlated with CRT(r =-2.16,P ＜ 0.05).Conclusions The central retinal thickness is negatively correlated with the best corrected visual acuity,but not correlated with center mfERG in patients with IMEM.

Obiective To explore the application of psycho-cardiology in patients with chronic heart failture compli-cated with depressive disorder. Methods Hospitalized patients with chronic heart failture were assessed with PHQ-9 and PHQ-2 health questionnaire. A total of 80 patients with depressive disorder were selected and randomly divided into routine treatment group (n=40, received routine medication) and intervention group (n=40, application of psycho-cardiology based on routine medication). After three months, changes of scores before and after therapy were statistically analyzed in these two groups. Results Compared with routine treatment group, total scores of PHQ-9 significantly decreased in intervention group (P＜0.01). LVEF, BNP and CRP improved in both groups after intervention (P＜0.05), which were more prominent in intervention group compared with routine treatment group (P ＜ 0.05). Conclusion Psycho-cardiology can treat chronic heart faiture and solve psychological problems of patients and provide comprehensive rehabilitation to patients.