OBJECTIVE:To investigate clinical effects of aescuven forte combined with routine drugs in the treatment of vari-cocele(VC). METHODS:A total of 86 patients with VC selected from our hospital during Feb. 2015-Jan. 2016 were divided into control group and observation group according to odd and even number,with 43 cases in each group. Control group was given rou-tine drug therapy. Observation group was additionally given Aescuven forte tablet 300 mg,po,bid,on the basis of control group. Treatment course of 2 groups lasted for 3 months. Clinical efficacies as well as testicular artery blood flow parameters,seminal plas-ma lab indexes and semen quality were compared between 2 groups. The occurrence of ADR was also compared between 2 groups. RESULTS:Total response rate of observation group was 90.70％,which was significantly higher than 72.09％ of control group, with statistical significance (P<0.05). Before treatment,there was no statistical significance in above indexes between 2 groups(P>0.05). Compared to before treatment,testicular artery peak systolic velocity,resistance index and pulsatility index of 2 groups were decreased significantly after treatment,while plasma α-glucosidase,acid phosphatase,Fructose,sperm activate rate of for-ward movement,total sperm activate rate and sperm density were increased significantly;each index of observation group was bet-ter than that of control group,with statistical significance(P<0.05);there was no statistical significance in end diastolic velocity between 2 groups before and after treatment(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Aescuven forte combined with routine drug therapy help to improve testicular artery blood flow status of VC patients,regulate the content of semi-nal plasma related molecules and improve semen quality so as to improve clinical efficacy with good safety.