Twenty- five patients with severe head injury underwent early total parenteral nutrtion (TPN) support,and the blood glucose,serum albumin,body nutritional index and nitrogen balance were monitored in our case- controll study.We find that the patients with severe head injury could get more energy and protein from TPN than from enteral nutrition (EN) ,the mortality of the patients with TPN was significantly lower than the patients with EN.The total nutrient admixture(TNA) in our study can provide sufficient energy and protein,but cannot raise blood glucose,so it can make a good condition for the recovery of the severe head injuries.