Objective To observe the clinical curative effect of Semen Cassiae application on navel in treating essential hypertension. Methods Totally 1674 cases of hypertension, according to visiting sequence, were randomly divided into treatment group (864 cases) and control group (810 cases). The control group was given hydrochloride enalapril 10 mg orally, 2 times a day. The treatment group was treated with Semen Cassiae application on navel, replaced per 24 h. The two groups were treated with moderate exercise, reasonable diet, and the course was 6 months. The clinical symptoms, blood pressure, blood lipid and blood rheology of the two groups were measured before and after treatment. Results To compare the symptoms efficacy, total effectiveness of treatment group was 95.14%(822/864), the control group was 71.11%(576/810), there was a significant difference (P<0.01). To compare antihypertensive effects, the total effective rate of the treatment group was 95.60% (826/864), the control group was 73.46% (595/810), there was a significant difference (P<0.01). The change of blood pressure in the treatment group was significantly better than the control group (P<0.01). TC, TG, HDL-C, LDL-C and blood rheology of the treatment group was significant different between before and after treatment (P<0.01). Conclusion On the basis of western medicine, Semen Cassiae application on navel played a double effect of acupoint and drug. It is more effective in lowering blood pressure, improving the clinical symptoms, blood lipid and blood rheology indexes.