OBJECTIVE:To investigate the method for preparation and quality control of ornidazole oral membrane.METHODS:Ornidazole oral membrane was prepared with polyvinyl alcohol and sodium carboxymethylcellulose as its adju-vants;The content of ornidazole was determined by ultraviolet spectrophotometry at the wavelength of316nm.RESULTS:There was a good linear correlation within a range of6.0～18.0?g/ml(r=0.9997)of ornidazole concentration,the average recovery was100.19%(RSD=0.66%,n=5).CONCLUSION:The established technique is simple,and the content deter-mination is quick,precise and reliable.

Planar cell polarity pathway regulates cell polarity and polarized cell movements.Recent studies in mouse models have found mutations in several genes in this pathway and specifically in the Vangl2 gene,which results in abnormalities in cardiac development,suggesting Vangl2 and this pathway play an important role in heart development.This review mainly elucidates the mechanisms regulated by the Vangl2 gene and PCP pathway during outflow tract development and the formation of the coronary vasculature.

AlM: To establish the frequency, associations and risk factors for age-related macular degeneration ( AMD ) in hospital population.
METHODS: ln this hospital based study, 589 subjects above 60 years of age were screened randomly for AMD. Participants underwent ocular evaluation and were interviewed for lifestyle variables and dietary intake of carotenoids by structured food frequency questionnaire. AMD was defined according to the international classifications and grading system.
RESULTS: Either form of AMD was detected in 48 participants. AMD was significant among diabetes, diabetic retinopathy, body mass index, heavy cigarette smokers and alcoholics ( P < 0. 05 ). Dietary lutein/zeaxanthin ( L/Z) and β-carotene intake were associated with the reduction in risk for AMD(P<0. 05).
CONCLUSlON: Higher dietary intake of carotenoids, especially L/Z, is associated with lower risk for AMD. Risk of AMD is prevalent among subjects with diabetes. Cessation of smoking and alcohol may reduce the risk of AMD in this population.

Objective Evaluation of enema application of Yiyi-Fuzi-Baijiang powder combined with oral sulfasalazine enteric-coated tablets in treating ulcerative colitis. Methods The patients with ulcerative colitis were randomly divided into 2 groups, 42 cases in each group. The control group was treated with sulfasalazine, and the observation group with sulfasalazine and Yiyi-Fuzi-Baijiang powder. Both groups were treated for 4 weeks. ELISA method was used to detect the levels of IL-6, IL-8 and TNF-α. The changes of disease activity index (Sutherland DAI) were observed before and after treatment, and the clinical efficacy was evaluated. Results After treatment, the Sutherland DAI (3.89 ± 0.91 vs. 4.91 ± 1.08, t=3.082) in the observation group was significantly lower than that in the control group (P=0.042). The level of TNF-α (20.82 ± 4.31 ng/L vs. 26.51 ± 5.25 ng/L, t=3.602), IL-6 (31.73 ± 4.82 ng/L vs. 40.18 ± 5.63 ng/L, t=3.817), and IL-8 (35.39 ± 4.62 ng/L vs. 40.59 ± 5.35 ng/L, t=3.341) in the observation group were significantly lower than those in the control group (P<0.05). The total efficiency of observation group was 92.9% (39/42), and the control group was 73.8% (31/42). There was significant difference between the two groups (χ2=4.200, P=0.040). Conclusions The Yiyi-Fuzi-Baijiang powder combined with sulfasalazine could relieve the clinical symptoms of ulcerative colitis patients with spleen-kidney yang deficiency, and inhibition inflammatory response.

The paper elabrates the function of bibliographic management software in either managing literatures or writing papers, as well as the noted problems of college and university libraries carrying out bibliographic management software training. It also points out the importance of the software application in medical information literacy education.

Objective To introduce a patent: The assembled equipment of external counterpulsation with an oxygen mask in the treatment of ischemic diseases that has been opened by the national property right bureau of knowledge.Methods Based on the current equipment,oxygen was provided with a mask along with external counterpulsation.Results It could enhance blood stream as well as the blood oxygen rate.Conclusion Assembled equipment of external counterpulsation with oxygen mask can enhance cure speed and rate in the treatment of ischemic diseases.

Objective: Thyroid nodules are common clinical thyroid disorders.The purpose of this study was to investigate the diagnostic value of the clinical characteristics and various parameters of malignant thyroid nodules and the sensitive indexes for their differentiation so as to improve the diagnosis of malignant thyroid nodules and avoid unnecessary procedures or operations.Methods: We retrospectively studied 600 cases of thyroid nodules treated by surgery from 2001 to 2008,divided them into a benign and a malignant group according to the pathological results,and analyzed by multivariate logistic regression the correlation between the nature of thyroid nodules and various factors.Results: Of the 600 cases of thyroid nodules,519(83.47%) were benign and 81(16.53%) were malignant.Clinical symptoms and signs,ultrasonography and CT were all useful in indicating malignancy,especially ultrasonography,whose specificity and diagnostic accuracy were 93.3% and 84.2%,respectively.Multivariate logistic regression analysis revealed a higher rate of malignancy in younger patients with solid or hard nodules,or accompanied with calcification or painless adenophyma in the neck.Conclusion: Clinical symptoms and signs,ultrosonography and CT are of significant value in the diagnosis of malignant thyroid nodules.

[Objective]To study the influence of meretrix polysaccharides on immune functions in the experimental diabetic rats.[Method]The experimental diabetic rats were yielded by streptozotocin(25mg/kg i.v)and fed with hyperotophic foods,then we used meretrix polysaccharides to treat the type Ⅱdiabetes rats and observed erythrocyte immune adherence function and T lymphocyte subsets in the experimental rats.[Results]The erythrocyte C3b receptor ratio(E-C3bRR)decreased 37.92% and the erythrocyte immune compound ratio(E-ICR)increased 64.36%,T lymphocyte subgroup(CD3、CD4、CD8)lowered 25.49%,26.54%,16.85% respectively.All of the above mentioned parameters in the model group were significantly different from that of the control group(P

National Cancer Institute initiated the project of building the cancer genome anatomy project in order to find a series of indices to retrieve information about genes,proteins and other biological markers related to cancers in 1996.At present,the project has been speeded up with the help of advances in the development of bioinformatics that could provide enormous biological information.Several bioinformations techniques that are commonly used include: Expressed Sequence Tags,Unigene,Serial Analysis of Gene Expression and Digital Differential Display.Each method has its own advantages,which together make up the bioinformatics technology.In this article,we reviewed the application of bioinformatics in cancer research and predict its trend.