Renal protection should be taken into account when we treat chronic gouty arthritis patients combined with chronic kidney disease.Several drugs should be individualized and adjusted dosage according to renal function parameters such as GFR.At the same time,we should closely monitor the side-effects of drugs.

ObjectiveTo observe the efficacy and safety of house dust mite vaccine in the treatment of house dust mite-allergic rhinitis.Methods47 patients with allergic rhinitis were recruited into the study.The course of SIT was treated by house dust mite vaccine for 51 weeks.Self-contrast method was used to compare the symptom score,nasal airway resistance before and after treatment.Then we observed the security in the process of injection.ResultsThe symptom score was (7.40 ± 1.64) vs ( 3.40 ± 1.50 ) pre and post therapy.Nasal airway resistance were (2.02 ±0.72) vs ( 1.06 ± 0.81 ) kPa · s -1 · L-1.Both the values of the data had significant differences( t =15.49,4.44,all P ＜ 0.01 ).No serious adverse reaction was observed.ConclusionSIT was able to improve the clinical symptoms and decrease nasal airway resistance.House dust mite vaccine was an effect and safe drug for the dust mite allergic asthma patients.

Differentiated epithelial cells could be transformed into mesenchymal cells through the epithelial-mesenchymal transi-tion (EMT), which is important for tumorigenesis and metastasis. Recent studies suggest that EMT is closely correlated to the resistance to chemotherapy of tumors. This chemoresistance could enhance tumor malignancy, which includes the induction of the EMT pheno-type. The paper reviews the research progress on EMT and its association with drug resistance of tumors.

Objective To explore the impact of resilience and anxiety, depression on quality of life (QOL) among esophageal carcinoma patients undergoing radiotherapy and (or) chemotherapy. Methods A total of 125 patients were recruited into our study. Date were collected by European Organization for Research and Treatment of Cancer, Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) , Resilience Scale (RS) and Hospital Anxiety and Depression Scale (HADS). Analysis of Moment Structures (AMOS) version 7.0 software was used to conduct the path analysis. Results The total score of patients′ QOL, RS and HADS were(51.98±19.42)points,(56.32±17.09)points,(14.59±7.04)points. Pearson′s analysis showed that QOL was correlated with RS and HADS ( r =0.423-0.588,P<0.05). RS was negatively correlated with HADS (path coefficient was-0.76 and-0.37) and HADS negatively correlated with QOL (path coefficient was-0.56 and-0.79). RS as a protective factor indirectly influenced QOL via HADS and the paths′ total coefficients was 0.69. Conclusions The level of QOL and RS were at poor level for esophageal carcinoma patients, as well as participants experienced anxiety and depression. HADS as intermediary variable has a greater moderating effect on relationships between RS and QOL. RS is a indirect protective factor of QOL. Interventions developed on the basis of influencing factors of QOL should be applied to improve patients′integral health status.

The prevalence of obesity and obesity-related comorbidities is rising. Primary care physicians are the frontline of healthcare and play a central role in the management of obesity. In this article, we discuss the 5As framework (Ask, Assess, Advise, Agree, and Assist) as a practical framework for obesity counselling, focusing on initiating the conversation and assessing the person with obesity. The assessment includes taking a weight history, excluding secondary causes, understanding lifestyle factors contributing to weight gain and assessing for complications of obesity. This assessment then makes it possible for subsequent patient engagement, including advising, agreeing (goal setting), and assisting the patient on an individualised care plan.

Objective To investigate the depression after stroke in middle-aged patients and discuss the mental nursing.Methods Self-Rating Depression Scale was used to find 30 depression patients from 52 patients with stroke.They were analyzed and accepted mental nursing.Results The rate of depression mental state patients in 52 patients is 57.69%.After accepting mental nursing,the number of unsociability,morose and fatigue decreased,while that of role adaptation and self-confident increased significantly(P<0.05).Conclusion There is high incidence of depression in middle-aged patients with stroke.Mental nursing is helpful improve their adaptation and quality of living.

Objective To evaluate the effects of hemodialysis in aged patients with chronic renal failure,decrease complications,to improve their survival rate.Methods The clinical datas of aged patients suffering from CRF who received maintenance hemodialysis were summarized and analyzed about the survival,the cause of death and common complications.Results The commonest causes of death in aged patients with maintenance hemodialysis were cardiovascular events,infection and malnutrition.The common complications were cardiac insufficiency,infection.Conclusion Providing individual enough HD and treatment,improving nutritional situation,anemia and controlling infection may contribute to the reduction of the complications and the increasing of survival rate.

[Abstract ]Objective:To estimate dental maturation norms of permanent dentition in a group of Nanjing children using Nolla's tech-nique.Methods:549 cases of panoramic radiographs (279 males and 270 females)of Nanjing children at the age range of 3 to 16 years were collected for the study.All permanent mandibular teeth on the left side (except for the third molars)were scored according to Nolla's method,and data were presented in tables and used to plot dental maturation curves for the Nanjing boys and girls.Results:Females were found to be more advanced in the degrees of dental development.Dental maturation is significantly associated with chron-ological age (for males and females:r =0.959,P <0.001 and r =0.953,P <0.001,respectively).The mathematical model of them was established,and then the fitting equation was obtained.Conclusion:The dental maturation curve and chronology of permanent dentition can provide the growth norms of permanent teeth for Nanjing children and facilitate the way for dentists to assess the growing children during diagnosis and treatment planning.

Objective To explore the ultrasonographic, clinical and histopathological characteristics features of primary uterus lymphoma. Methods The clinical, sonographic and histopathological characteristics of nine patients who were pathologically comfirmed as primary uterus lymphoma were analyzed. Results Among the nine cases of primary uterus lymphoma, three lesions were found in the uterine bodys and 6 were found in the cervixes. Two patients with uterine body lymphoma had painless pelvic masses and six patients with cervix lymphoma had contact bleeding, including irregular vaginal bleeding in four patients. In sonograms, six lesions showed remarkable hypoechogenicity with homogeneous internal echogenicity;the margins of most lesions were circumcribed;all lesions had posterior enhancement. In color Doppler lfow imaging, abundant vascularities were detected in eight lesions. In the cases of uterine body lymphoma, all of the uterine bodys showed diffuse symmetrical enlargement without disruption of the endometria, while in ifve cases of cervix lymphoma, the tumors showed the shape of lobule. The pathological examination showed that all tumors were diffuse B-cell type non-Hodgkin lymphoma. Conclusions Primary uterus lymphoma has some clinical and ultrasonic features, including contact bleeding or irrgular vaginal bleeding, diffuse symmetrical enlargement of uterine body, complete endometria, remarkable hypoechogenicity, homogeneous echogenicity and posterior enhancement. Final diagnosis depends on the histopathology.

Objective To investigate the status of pregnancy syphilis screening ,diagnosis,treatment,follow-up in Panyu district for improvement of management of pregnancy syphilis .Methods Using the method of a retro-spective survey,the follow-up data for 219 cases of patients were diagnosed with gestational syphilis from 2011.10.1 to 2013.9.30.Results 219 cases were diagnosed with gestational syphilis in 103 665 cases of pregnant women .The positive rate was 2.1%and all cases were latent syphilis .176 cases underwent a course of treatment during pregnancy , of which 33 patients received two courses of standard treatment .40 cases didn't receive treatment and 3 cases could not be followed up due to the phone empty ,shut down or refuse .14 cases were congenital syphilis ,the rate was 6.4%. Conclusion Pregnancy syphilis is a serious mother to child transmission of disease .After standard treatment ,close follow-up,strengthen publicity and education to improve patient compliance can reduce the incidence of congenital syphilis.