1.Determination of Related Substances in Erythromycin Ophthalmic Ointment
Xiaodong ZHAO ; Rong FU ; Yu ZOU
China Pharmacist 2015;18(12):2168-2170
Objective:To establish a method for the determination of related substances in erythromycin ophthalmic ointment. Methods:The extraction method was established and optimized. An HPLC gradient elution method was used for the determination of related substances in erythromycin ophthalmic ointment. Results: One step extraction with PBS (pH 7.0) - methanol(1: 1) had promising effect. After the method validation, it was proved that the method could be used to determine the related substances in eryth-romycin ophthalmic ointment. Conclusion:The method established in the paper provides a better analytical extraction and determina-tion method for the quality control of erythromycin ophthalmic ointment.
2.Multiple regression analysis of urinary fluoride, s aliva and plaque fluoride levels of adolescents dental fluorosis
Yangyang YU ; Wei ZHAO ; Xiaoyan LIU ; Dongrong ZOU ; Xiaoyun YANG ; Rong LIU ; Xiaofeng YU ; Jie YING
Chinese Journal of Endemiology 2016;(1):23-26
Objective The purpose of this study was to study the correlation between dental fluorosis, saliva and plaque fluoride levels and urinary fluoride values in adolescents dental fluorosis. Methods A middle school was chosen as a survey point in the study. Two hundred adolescents were examined the degree of dental fluorosis by Dean's method. These adolescents were divided into four groups according to the severity of fluorosis (n = 52, 40, 28 and 80). Fluoride ion specific electrode was used to measure the fluoride levels in dental plaque, saliva, urinary and drinking water. The differences were analyzed b y ANOVA. Correlation of the fluoride levels between dental plaque, saliva, urine and the degree of dental fluorosis were analyzed by the method of multiple linear regression. Results The average fluoride content of drinking water was (2.20 ± 0.40) mg/L. Compared with controls, the fluoride concentrations in dental plaque, saliva and urine were higher in light, medium and severe dental fluorosis groups [(1.55 ± 0.88), (1.94 ± 0.77), (2.74 ± 0.83) than (0.32 ± 0.20) mg/L; (4.44 ± 1.62), (8.09 ± 0.93), (10.72 ± 0.99) than (0.02 ± 0.01) mg/L;(31.77 ± 6.09), (57.98 ± 1.83), (65.98 ± 2.78) than (13.06 ± 2.11) μg/g, all P<0.05]. Urinary fluoride was correlated with fluoride in saliva and dental plaque (r=0.245, 0.440, all P<0.05). Saliva fluoride was correlated with fluoride in dental plaque (r=0.849, P<0.01). The degree of dental fluorosis was correlated with fluoride in urine and saliva (r = 0.497, 0.896, 0.924, all P< 0.01). The multiple linear regression equation between fluoride in urine and the degree of dent al fluorosis, fluoride in dental plaque and saliva was as follow: y = 1.357 + 1.618x1 + 0.001x2 - 0.331x3 ± 0.69. Conclusions The metabolism of fluoride in body is related with oral fluoride repository in adolescents dental fluorosis. Fluoride in urine is influenced by plaque fluoride level, saliva fluoride concentration and the degree of dental fluorosis.
3.Primary cardiac embryonal rhabdomyosarcoma: report of a case.
Liang GUO ; Zhen-yu WANG ; Ya-bin ZOU ; Li-rong BI
Chinese Journal of Pathology 2013;42(9):621-622
Calbindin 2
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metabolism
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Heart Neoplasms
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metabolism
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pathology
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surgery
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Humans
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Male
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Middle Aged
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MyoD Protein
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metabolism
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Myogenin
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metabolism
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Rhabdomyosarcoma, Embryonal
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metabolism
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pathology
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surgery
4.Primary small cell carcinoma of the breast: report of a case.
Li-mei QU ; Gang ZHAO ; Ya-bin ZOU ; Yu-E SONG ; Li-rong BI
Chinese Journal of Pathology 2011;40(2):120-121
Aged
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Breast Neoplasms
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metabolism
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pathology
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surgery
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Cadherins
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metabolism
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Carcinoma, Merkel Cell
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metabolism
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pathology
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Carcinoma, Small Cell
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Female
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Humans
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Lymphoma
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metabolism
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pathology
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Melanoma
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metabolism
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pathology
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Phosphopyruvate Hydratase
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metabolism
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Synaptophysin
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metabolism
5.Qualitative analysis of FDG uptake and blood perfusion by PET/CT in breast cancer
Haidong ZOU ; Qingwei LIU ; Rong MA ; Zhigang YU ; Chenggang WANG ; Xin LI ; Jingzhong SUN
Chinese Journal of General Surgery 2000;0(11):-
Objective To evaluate the use of PET/CT in the diagnosis of breast cancer. Methods In this study,33 patients with suspicious breast tumor underwent PET/CT imaging. The images of the breast were analyzed for qualitative assessment of increased tracer uptake and blood perfusion with PET/CT. Results Among 27 cases with pathology proved breast cancer,25 was judged as PET/CT positive,2 was false-negative. Sensitivity, specificity and accuracy of PET/CT in identifying breast cancer were 92.6%,100%,93.9%. Conclusion PET/CT is a reliable and sensitive measure in the diagnosis of breast cancer in vivo.
6.Regeneration of rabbit mandibular defects with composite scaffold materials of SIS and nm ?-TCP
li, HUA ; jia-yu, LU ; xiao-ping, CHEN ; de-rong, ZOU
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(07):-
Objective To determine whether the small intestinal submucosa(SIS)/nano meter crystal ?-tricalcium phosphate(nm ?-TCP) composite can enhance the regeneration of rabbit mandibular defects. Methods Twenty-six mandibular defects were made on thirteen New Zealand rabbits,and were ramdonly divided into four groups: groupⅠ,single SIS was applied to each defects;group Ⅱ,nm ?-TCP;groupⅢ,the composite scaffold materials of SIS and nm ?-TCP;groupⅣ,control.Twelve weeks after the operation,the samples were extracted for gross observation,histological analysis,X-ray examination,and relative bone density(RBD) recording.Results Twenty weeks after the operation,the newborn bone trabecula took up most of the area with defects.The restorative materials in the SIS group and composite scaffold materials group had almost degraded,and little remained in the ?-TCP group.The composite scaffold materials group was found more newborn bone trabecula with mature formation,and the average RBD was relatively higer,while less newborn bone trabecula with irregular formation and more collagen were observed in the control group. Conclusion The composite materials of SIS and nm ?-TCP,which enjoy favourable bone formation characteristics and histocompatibility, can enhance bone regeneration in rabbit mandibular defects.
7.Study on Bioequiavailability in Human Body between Domestic and Imported Roxithromycin
Yubing ZHU ; Dawei XIAO ; Jianjun ZOU ; Wei QIAN ; Yunfang HU ; Cuixia YU ; Rong GU
China Pharmacy 2005;0(16):-
OBJECTIVE:To study the bioequiavailability of domestic roxithromycin tablets and imported ones.METH?ODS:20male healthy volunteers took single dose of150mg roxithromycin tablet orally in a random crossover design,blood concentrations were determined by LC-MS.RESULTS:The main pharmacokinetic parameters of domestic and imported tablets were determined respectively as follows,AUC 0~72 were(72.81?23.85)(mg?n)/L and(72.63?20.86)(mg?h)/L,AUC 0~∞ were(74.41?24.45)(mg?h)/L and(74.42?24.45)(mg?h)/L,C max were(6.46?1.51)mg/L and(6.58?1.55)mg/L,t max were(1.9?0.5)h and(1.8?0.5)h,t 1/2 were(13.56?1.35)h and(14.18?1.50)h,the relative bioavailability of the homemade tablet to imported one was(99.8?11.2)%.CONCLUSIONS:Domestic and imported roxithromycin are bioequivalent.
8.Evaluation of PET/CT imaging versus mammography in detecting breast cancer
Haidong ZOU ; Rong MA ; Zhigang YU ; Qingwei LIU ; Chenggang WANG ; Xin LI ; Jingzhong SUN
Chinese Journal of General Surgery 1997;0(04):-
0.05). Conclusions In comparison with mammography,PET/CT has a higher degree of sensitivity and specificily in detecting breast cancer,and higher positive predictive value.PET/CT can provide more aspects of in vivo diagnostic information which may be useful in selecting therapeutic strategy and may supplement the inadequacies of mammography.
9.Urinary interleukin-6 level was associated with urinary tract infection in patients with type 2 diabetes mellitus
Yun DENG ; Xiaobo FEN ; Rong PENG ; Weihong YU ; Lijun ZOU ; Lijuan YANG ; Wei CHENG ; Ruipin HE
Chinese Journal of Endocrinology and Metabolism 2011;27(3):213-214
The association of urinary cytokine concentration with the incidence of urinary tract infection in patients with diabetes mellitus was explored. Urinary interleakin-6 (IL-6) level in 156 female type 2 diabetes mellitus patients was tested and followed up for 6 months. The incidence of urinary tract infection between the top quartile of baseline urinary cytokine concentration with the bottom quartile was compared. The incidence of top quartile of urinary IL-6 concentration at baseline was significantly lower than that of bottom quartile ( 13.5% vs 37.8%, P<0.05 ). Abnormality of urinary IL-6 concentration may be involved in the mechanism leading to higher prevalence of urinary tract infection in patients with diabetes mellitus.
10.Influencing factors of depressive symptoms in Zhejiang adolescents
LI Juan Juan ; ZHANG Rong Hua ; ZOU Yan ; GU Fang ; MENG Jia ; GAO Lei ; SHEN Yu
Journal of Preventive Medicine 2021;33(2):139-142
Objective:
To investigate the prevalence and influencing factors of adolescent depression symptoms in Zhejiang, so as to provide reference for improving their mental health.
Methods:
The middle school and university students in 11 cities of Zhejiang Province were selected by stratified cluster random sampling method. The depression symptoms of the adolescents were assessed by Center for Epidemiological Survey-Depression Scale ( CES-D ) and the influencing factors were analyzed by multivariate logistic regression model.
Results:
A total of 25 855 students were investigated, and 25 614 ( 99.07% ) valid questionnaires were collected. The detection rate of depressive symptoms was 26.86%(6 879 cases). The detection rate of depressive symptoms in girls was 29.75%, which was higher than 24.12% in boys ( P<0.05). The detection rate of depressive symptoms in high school students was 31.74%, the highest compared with other grades. The multivariate regression analysis showed that female students ( OR=1.690, 95%CI: 1.592-1.794 ), resident students ( OR=1.071, 95%CI: 1.010-1.137 ) , internet addiction ( OR=2.948, 95%CI: 2.527-3.439 ) , attempt smoking ( OR=1.516, 95%CI: 1.359-1.690 ), drinking ( OR=1.624, 95%CI: 1.525-1.729 ), bullied in the past 30 days ( OR=3.143, 95%CI: 2.938-3.363 and having serious injuries within a year ( OR=1.369, 95%CI: 1.263-1.543 ) were associated with adolescents who had depressive symptoms.
Conclusions
The detection rate of depressive symptoms is relative 26.86% among adolescents of Zhejiang Province. The students who are female, live on campus, have internet addiction, have been bullied or seriously injured, smoke and drink are more likely to have depressive symptoms.