Biological Therapy ; Carcinoma, Neuroendocrine ; Thyroid Neoplasms ; therapy

Hepatic Encephalopathy ; classification ; diagnosis ; therapy ; Humans ; Terminology as Topic

Based on the reality of Anhui Medical University,the paper analyzes the adverse factors of carrying out combination with teaching for the literature retrieval course from the perspectives of emphasis,professional knowledge structure and teachers of professional courses,and puts forward corresponding countermeasures from implementation of teaching and teaching effect,in order to provide reference for medical colleges to carry out literature retrieval course effectively.

Anniversaries and Special Events ; Humans ; Learning ; Medicine, Chinese Traditional ; Physicians

By means of the observation of acridine orange-stained lysosomes with fluorescence microscope, we studied the intracellular killing and digestive process after alveolar macrophage (AM) ingested living-yeast. Based on the morphological changes of the cells, we divided the process into three stages: the pre-phagosome-lysosome fusion stage, the phagosome-lysosome fusion and killing stage, and the digestive stage. The results revealed that all the values of phagocytic index, phagocytic rate, fusion index and fusion rate of the isolated AM of rabbits infected with living-BCG were higher than those of normal rabbits (P

Alveolar macrophages (AM) were studied by means of phase contrast microscope, differential interference contrast microscope, SEM and TEM. The content of AcP, LDH, SDH of the AM was measured by MPV3-TSA microspectrophotometerimage analytical instrument. Under phase contrast microscope, two different types of AM can be distinguished, i. e, the light cells and the dark cells. The two types of cells are spherical and flat in shape under differential interference contrast microscope. The observation with SEM and TEM showed that the spherical cells possess more filopodia and more lysosomes in cytoplasm, but the flat cells possess more lamellar podia. Quantitative cytochemistry demonstrated that the content of AcP, LDH, SDH in spherical cells are much more than that of flat cells. The results suggest that there are two types of alveolar macrophages exist in normal rat lung.

The phagocytic ability and fashion of two types of alveolar macrophages (AM) on coal dust were studied by differential interference contrast microscope, scanning electron microscope and image analyser. This study revealed the phagocytic ability of spherical AM on dust was higher than that of the flat AM. Both types of AM could extend long tenuous filopodia to the coal dusts around the cells. The coal dusts were attached to the cell surface and then were sunk into the macrophage. The amount of the phagocyted coal dusts per unit time were measured by image analytical method which is more exact than other methods. This paper provided not only a new approach for study phagocytosis of macrophage on inorganic dusts, but also some essential morphologic evidences for study of pneumoconiosis.

Objective To observe the effect of ulinastatin on NT -proB -NP and Picco in patients with severe sepsis.Methods 50 patients with severe sepsis were randomly divided into the control group and observation group,25 patients in each group.The control group received the routine treatment,and the observation group received ulinastatin additionally.The venous blood was collected to determine cTn -I,NT -proBNP,TNF -αand Lac before treatment and 7 days after treatment.The APACHE Ⅱ and CFI were observed before treatment and 7 days after treat-ment.Results The differences of CFI,cTnI,NT -proBNP in the two groups before treatment were not significant (t =0.419,0.321,0.335,all P >0.05),after treatment,cTnI and NT -proBNP decreased more significantly(t =2.976,2.910,all P <0.05),while lifting more apparent CFI[(3.98 ±0.95)vs.(2.39 ±0.85),t =6.237,P <0.05]in the observation group than in the control group.The differences of TNF -αand Lac in the two groups before treatment were not significant (t =0.602,0.848,all P >0.05 ),after treatment,TNF -αand Lac decreased significantly faster in the observation group than in the control group(t =8.478,3.104,all P <0.05).After treat-ment,APACHE Ⅱ score decreased significantly in observation group than in the control group(t =2.321,P <0.05). Conclusion Ulinastatin had protective effects on heart function in patients with severe sepsis.

Objective To investigate the changes and the significance of the contents in matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in plasm of patients with intracerebral hemorrhage (ICH). Methods The contents of MMP-2 and MMP-9 in plasm of 50 patients with ICH and 50 healthy people (control group) were measured respectively through ELISA methods. Results Compared with the control group,the increase of the contents of MMP-2 and MMP-9 had obvious statistic significance in plasm of patients with ICH (P0.05),but they had obvious statistic significance in the comparison among other time groups (P

BACKGROUND:Number of experimental and clinical studies have shown that stem celltransplantation can establish new blood vessels and improve heart function instead of necrotic myocardium, to significantly improved clinical symptoms and prognosis of cardiovascular disease patients.
OBJECTIVE:To observe the safety of human umbilical cord blood mononuclear cells transplantation in patients with coronary heart disease and heart failure.
METHODS:A total of 12 patients with coronary heart disease and heart failure (acute myocardial infarction and heart failure in six cases, old myocardial infarction and heart failure in six cases) were enrol ed in this study. Patients were treated on the basis of standard medication and percutaneous coronary intervention. The coronary pathway was established via a percutaneous catheter, and suspension of cord blood mononuclear cells was injected through microcatheter into the distal artery. Routine blood test was carried out at 1 week after celltransplantation, blood routine, liver function, kidney function, C-reactive protein, IgA, IgG were compared preoperatively and postoperatively.
RESULTS AND CONCLUSION:The incidence of adverse reactions in cord blood stem celltransplantation was 8.3%, including one case of fever. No micro-embolism occurred. During 1-week fol ow-up, no graft-versus-host disease appeared. After celltransplantation, there were no significant changes in blood routine, liver function, kidney function, C-reactive protein, IgA, IgG. These findings indicate umbilical cord blood monomuclear cells transplantation is safe in a short term for patients with coronary heart disease and heart failure.