Objective To study the relationship between helicobocter pylori(Hp)infection and iron deficiency anemia(IDA)in children.Methods Children who had upper digestive symptom were had gastroscopy examination and Hp test.According to the examination results,all the patients were divi-ded into 2 groups,the observation group and the control group.All patients were detected blood routine,serum iron(SI),serum ftrritin(SF)and total iron-binding capacity(TIBC).Results The IDA morbidity was 52.27%(23/44 cases)in obsorvation group and 17.39%(8/46 cases)in control group,there was obvious difference between two groups(?2=12.12 P

Objective To explore the clinical effect of atomoxetine on children with attention deficit hyperactivity disorder(ADHD)comorbid tic disorder.Methods The children who met the criteria of Mental Disorders Diagnostic and Statistical Manual diagnostic criteria for ADHD and tic symptoms were given systematic atomoxetine titration reaching the optimum dose.ADHD and tic symptoms were evaluated with ADHD rating scale-Ⅳ(ADHD-RS-Ⅳ)for parents Yale Global Tic Severity Scale(YGTSS),respectively.Results Twenty children with ADHD comorbid tic disorder [17 male,3 female;age range 7.58-17.0 years,mean age(10.55?2.58)years] completing systemic titration was enrolled in the study,including 10 subjects with ADHD-inattentive type,9 mixed type,and 1 hyperactive/impulsive type.The mean optimal dose was(1.19?0.21)mg/(kg?d).The total score(12.65?9.08)scores,inattention score(7.45?4.75)scores and hyperactivity/impulsivity score(3.0)of ADHD-RS-Ⅳ decreased significantly post-treatment compared with pro-treatment(31.10?8.52,17.60?3.09,and 13.0 scores,respectively,P

Background Sugar cataract is one of the major diabetic complications in the eye,but there is not effective medicine to prevent or delay development of cataract. Objective The goal of this study was to investigate the effects and the potential mechanism of aldose reductase (AR) inhibitor,AL-1576 on prevention of galactose cataract in rats. Methods Forty-two SD rats were randomly and equally divided into 7 groups.The cataracts were induced by feeding with 50％ galactose.At the day of feeding galactose and the day 5,10 and 15 after feeding galactose,AL-1576 was added into the feeds.The rats were divided AL-1576 prevention group and early-,intermediate-or late-stage intervention groups.For another group,the withdrawing AL-1576 group,AL-1576 was added into the feeds at the day of feeding galactose,then was removed after 10 days.The lenses of the rats were examined under the slit-lamp microscope before and after given AL-1576 every 5 days.At the day 35,the lenses were obtained.The wet and dry weight of the lenses were weighted,respectically,to calculate the water content of the lenses.Activities of AR and superoxidedismutase (SOD) and contents of glutathione (GSH) of the lenses were measured by their commercial detecting kits.The care and use of the animals complied with the Regulations for the Administration of Affairs Concerning Experimental Animals by State Science and Technology Commission. Results In AL-1576 prevention group,all lenses maintained clear.Opacification of the lenses were significantly attenuated in all three AL-1576 intervention groups and withdrawing AL-1576 group compared with the cataractous model group ( P＜0.05),but the inhibiting role was weaken with late intervention.The water contents and the activities of AR of the lenses were decreased,the contents of SOD and GSH were dramatically increased in all different AL-1576 treated groups compared with the cataractous model group (P＜0.05).Moreover,AL-1576 prevention group showed the best effect on all indexes (P＜0.05). Conclusions The activity of AR can be inhibited by AL-1576 at the different stages of development of cataract induced by galactose.By blocking and attenuating formation of the edema and elevating antioxdative capacity in the lenses,AL-1576 prevents and delays the formation of galactose cataract.

Objective To study the risk factors of aortic arch calcification (AoAC) in maintenance hemodialysis (MHD) patients.Methods Retrospective analysis was performed in patients who accepted MHD ≥ 5 years.The clinical data were collected.The images of plan chest radiograph detected during followup period were reviewed by certain imaging physicians,and the AoAC score was calculated.Logistic regression model analysis was proceeded to study the risk factors of AoAC.The patients were divided into AoAC positive group (29 cases) and AoAC negative group (37 cases) respectively.The clinical parameters were compared between the 2 groups.Results Sixty-six patients (21 male,45 female) were selected.The year AoAC scores from the zeroth to fifth year were (0.013 40 ± 0.074 96),(0.018 90 ± 0.078 55),(0.118 50 ± 0.170 06),(0.157 00 ± 0.207 55),(0.166 00 ± 0.205 37),(0.175 50 ± 0.222 29) scores,progressively.There were significant differences in AoAC score from the third year compared with that of the zeroth year (Z =-3.984,-4.021,-4.017;P ＜ 0.01).Logistic regression model analysis result showed that only the age of dialysis beginning was the risk factor for AoAC (relative risk 1.177,regression coefficient 0.163,P =0.002).The age of dialysis beginning,rate of diabetic nephropathy,serum calcium-phosphate product were significantly higher in AoAC positive group than that in AoAC negative group [(59.5 ± 12.6) years vs.(52.9 ± 13.2) years,27.6％(8/29) vs.2.7％(1/37),(5.81 ± 1.63) mmol2/L2 vs.(4.13 ± 0.86) mmol2/L2].Conclusions The AoAC will aggravate with the increased duration of dialysis in MHD patients.The age of dialysis beginning is the risk factor of AoAC.

Objective To observe the clinical effectiveness of alprostadil combined to pancreatic kininogenas in the treatment of gerontal diabetic peripheral neuropathy.Methods Totally 90 gerontal patients with diabetic peripheral neuropathy were randomly divided into three groups,the first group received the treatment of mecobalamin,the second group received mecobalamin plus pancreatic kininogenas,the last group received mecobalamin,alprostadil and pancreatic kininogenas (30 cases for each).The course of treatment was 4 weeks,the nerve conduction and effective rate of 3 groups were compared after treatment.Results Compared with the first group(53.3％),the total effective rate was significantly improved in the second group (80.0％)and the third group(100.0％) (P＜0.05).After treatment,the therapeutic effect of every group was boosted,and the second group was better than the first group,and the last group was best(P＜0.05).Conclusions Alprostadil combined to pancreatic kininogenas is effective and safe for the treatment of elderly diabetic peripheral neuropathy.

Adult ; Aged ; Alveolar Ridge Augmentation ; methods ; Dental Implantation ; methods ; Female ; Humans ; Male ; Maxillary Sinus ; surgery ; Middle Aged

Atherosclerosis ; complications ; pathology ; Humans ; Thrombosis ; complications ; pathology

Objective To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on sedative efficacy during induction of anesthesia with propofol.Methods Patients,of ASA physical status Ⅰ or Ⅱ,aged 21-69 yr,scheduled for elective thyroid surgery,were randomly divided into 2 groups using a random number table:control group (group C) and TEAS group.TEAS was applied to bilateral Hegu and Neiguan acupoints for 30 min.The frequency was 2/100 Hz,wave length was 0.2-0.6 ms and the intensity was maintained at about 8-12 mA according to the current that could be tolerated.Induction of anesthesia was started at the end of TEAS.Sequential method was used to determine the median effective target plasma concentration (EC50) of propofol causing loss of consciousness in each group.The initial target plasma concentration of propofol was 3 μg/ml.BIS value was recorded every 30 s within 5-8 min after loss of consciousness and the average BIS value was calculated.It was considered to be positive response when the average BIS value was below 50.The target concentration of propofol was decreased/increased by 0.3 μg/ml in the next patient.Results EC50 of propofol causing loss of consciousness was 3.08 μg/ml in group TEAS,and 3.70 μg/ml in group C,and there was significant difference between the two groups.Conclusion TEAS can enhance the sedative efficacy during induction of anesthesia with propofol in the patients.

Objective To approach the capacity of erythrocyte regulating IL-8 in patients with primary hepatocarcinoma (PHC) by a new experimental system of hemaimmune. Methods 0.2ml suspension of cancer cells (S180: 5?10~6/ml) or NS were added into 0.2ml anticoagulant suspension of whole blood cells or leukocytes and 0.3ml plasma, then incubated for 1 h at 37℃. The content of IL-8 was determined by ELISA. Results In the patients with PHC, the IL-8 levels (pg/ml) in experimental and control groups of whole blood cells, and in experimental and control groups of leukocytes were 376.35?243.96, 353.64?271.92, 461.27?277.11 and 424.97?278.93, respectively; while in the normal human, they were 11.36?6.93, 4.98?4.35, 29.41?30.66 and 20.77?24.20, respectively. In the patients with PHC, the activation rates of cancer cells in the experimental groups of both whole blood cell and leukocyte were 0.22?0.24 and 0.25?0.53, respectively; while in normal human, they were 2.49?2.33 and 0.75?0.21, respectively. In the patients with PHC, the IL-8 adsorption rate of erythrocyte in both experimental and control groups of whole blood cell were 0.22?0.18 and 0.17?0.33, respectively; while in normal human, they were 1.18?2.29 and 0.86?0.49, respectively. The IL-8 activated rates of erythrocyte in the patients with PHC was much lower than in the normal human (P

Background A stable diabetic cataract animal model is a premise for screening and evaluating the drug for cataract therapy.Galactose cataract model is widely used in relevant experimental study,but the onset,extent and the type of lens opacification may be different due to different modeling way.Objective This study was to investigate the manifestations and pathological characteristics of cataract induced by D-galactose.Methods Fifty-six SPF SD rats were randomly divided into cataract-model group and control group and 28 rats for each group.50% D-galactose feed was given daily in model group,and regular feed was given in control group.Lenses of rats were examined under the slit lamp through the 30-day period at a 2-day interval,and then the opacity of lenses was graded on the modified Suryanarayana criteria.The body weight of rats was recorded and compared between two groups at day 5,10,15,20,25 and 30.The lenses samples were obtained for the histopathological examination by hemotoxylin and eosin staining.The wet weight,dry weight of the lenes and their ratio were detected and compared between these two groups.The use of animals followed the Regulation for the Administration of Affair Concerning Experimental Animals by State Science and Technology Commission.Results The body weight was reduced in model rats compared with control rats with the statistically significant difference from 10 days through 30 days(P＜0.05).The different grades of opacification of lens cortical and nuclear progressed in model rats throughout the experiment duration,but the lenses were clear in control rats.The slit-lamp microscopy and pathological examinations revealed that lenses opacity in model rats started from the cortex at the equator zone and developed towards central zone gradually with the lapse of experimental time.Following the entire opacity of lens cortex,lens nucleus were cloudy and expanded.The swelling and degeneration of the fiber cells in lens cortex,the differentiation,migration and denuclearation delay of lens epithelial cells were seen in model rats under the light microscope.The wet weight of lenses was increased and the dry weight was decreased in model rats in comparison with control rats in experimental 30 days,showing significant difference between two groups(t=138.571,t=52.468,P＜0.05).Conclusion The development of galactose-induced cataract animal model resemble one of age-related cortical cataract in human with the similar generating mechanism.This cataract model is reproducible and classifiable.