Renal scarring can cause hypertension, proteinuria, chronic kidney disease, and even end stage renal disease. To understand the risk factors of renal scarring in children is helpful for its early detection, diagnosis, prevention, and treatment. High grade vesicoureteric reflux, recurrent urinary tract infection, and delayed treatment are risk factors for kidney scarring. However, there are still some controversies about the relationship between renal scarring and the some factors such as gender, age, and congenital factors. Recent studies have found that noninvasive urine indicators such as urine neutrophil gelatinase associated lipid delivery protein, urinary endothelin-1, and risk prediction models can predict the formation of renal scar. However, prophylactic use of antibiotics can reduce occurance of urinary tract infections, but do not reduce the risk of renal scarring. This article reviews the possible risk factors and predictors of renal scarring in children, providing a basis for early detection, timely intervention, and effective prevention of it in clinic, so as to reduce the formation and progression of renal scarring.

[Objective]To study the regulation effects of Oridonin on pulmonary artery pressure in pulmonary hypertension rats with hypoxia-hypercapnia and its mechanism.[Methods]SD rats were divided in to three groups randomly: the normal control group(NC),the hypoxia-hpercapnia group(HH),and the hypoxia-hpercapnia plus Oridonin group(O).The time of hypoxia-hypercapnia was 4 weeks.The mean pulmonary artery pressure(mPAP),right ventricular rate(RV/(LV+S)),percentage of thickness of pulmonary artery wall in vascular external diameter(WT%),percentage of pulmonary artery wall area in total vascular area(WA%),vitality of caspase3 and caspase9,expression cyt-c of each group were observed.[Results]The mPAP,RV/(LV+S),WT%,WA% in group HH were significantly higher than those in group NC(P

Administration, Topical ; Humans ; Immunosuppressive Agents ; administration & dosage ; adverse effects ; therapeutic use ; Lichen Planus, Oral ; complications ; drug therapy ; pathology ; Oral Ulcer ; drug therapy ; etiology ; Tacrolimus ; administration & dosage ; adverse effects ; therapeutic use ; Treatment Outcome

ObjectiveTo study the clinical effect of sodium aescinate on the edema of limb tibial plate fracture.Methods69 patients with edema of limb of tibial plate fracture were randomly divided into two groups,treatment group(46 cases)and control group(23 cases).Both of them were transfused with 20％ mannitol(250ml,Bid ×7days).In addition,these patients in the treatment group were treated with sodium aescinate(30mg Qd × 7days).ResultsThe repercussive effect of the edema grade in the treatment group were obviously better than those in the control group(P ＜0.05 ).ConclusionSodium aescinate had a remarkable repercussive effect on the limb edema of tibial plate fracture.

Objective To evaluate the treatment of acne vulgaris with acupuncture by different methods of point selection.Methods 51 cases of acne vulgaris were randomly recruited into local point selection group,distal point selection group and combination of local and distal point selection group.10 cases of healthy people were recruited for normal control group.Serum arachidonic acid (AA),free testosterone (FT),and sex hormone binding globulin (SHBG) levels were observed in all treatment groups.Results After the treatment,serum AA was (20.56±5.28)μg/L,(18.86±5.70) μg/L and (14.62±3.06) μg/L,while SHBG was (333.31±87.96) nmol/L,(332.02±87.82) nmol/L and (273.02±61.74) nmol/L respectively in local point selection group,distal point selection group and combination of local and distal point selection group,both showing no significant difference than the normal control group (P＞0.05).There was no significant difference in FT value between the combination of local and distal point selection group (5.62± 1.98) nmol/L and the normal control group (P＞0.05).The decrease of AA in the combination of local and distal point selection group was between than the local point selection group (P＜0.01).Conclusion Acupuncture can effectively improve the level of inflammatory factors and androgen of the acne vulgaris.Different methods of point selection of acupuncture on the improvement of some indicators were quite different,which laid the foundation for the best compatibility of acupuncture treatment in acne vulgaris.

Physical diasnostic techenique is the core curriculum of clinical medicine speciality. It is the bridge curriculum between basic medicine and clinical medicine. To further improve the teaching level of clinical medicine speciality and to reform personnel training mode of clinical medicine speciality in higher vocational college, we investigate the relevant content according to the work process curriculum course developing route.

The arterial supply of the human sacrum and coccyx was studied on 56 fresh. cadavers of different ages by dissection, clearing, casting and radiography.All sacrums receive their blood supply from the lateral sacral arteries, the median sacral artery, the iliolumbar arteries and the fifth lumbar arteries. The median sacral artery, the lateral sacral arteries and their branches anastomose with each other and form the lattice anastomosis on the ventral surface of the sacrum.The anterior spinal canal branch bifurcates into an ascending and a descending branches. The former passes upwards to join the descending branch from the anterior spinal canal branch above it, they also anastomose with their contralateral counterparts, thus forming a rhombic system notable for its regularity.The posterior spinal canal branch also divides into an ascending and a descending branches and they join each other to dispose in a ladder anastomosis on the ventral surface of the laminae.The dorsal branch gives off three main sets of branches: the lateral, the medial and the muscular. The medial and the lateral branches both subdivide into an ascending and a descending branches and they anastomose with each other on the dorsal aspect of the sacrum.On the ventral surface, the coccyx obtains arterial supply from the median sacral artery and the lateral sacral arteries, while its dorsal surface mainly receives blood supply of the lateral sacral artery. Anastomosis has been found scarce on the ventral and dorsal surfaces of the coccyx.

The arterial supply of the human sacrum and coccyx was studied in 68 fresh cadavers of different ages by dissection, clearing, casting and radiography.The nutrient arteries of the sacral vertebrae penetrate the body from the dorsal, ventral and lateral surfaces of the body. The central branches are the main nutrient arteries of the body. Their numbers are constant and do not increase with the advancement of age. The peripheral branches are variable and supply only the outer collar of the body. According to the distribution of nutrient artery within the body of the sacrum, they can be classified into three types 1. predominant ventral nutrient artery pattern, 2. predominant dorsal nutrient artery pattern and 3. balanced nutrient artery pattern. It is found that in S_4 and S_5, type 1 occurs more frequently while type 2 occurs usually in S_1 to S_3. Type 1 is relatively common in adults but type 2 is prevailing in fetuses. There is few balanced pattern in different age groups. Both ventral and dorsal nutrient arteries are distributed in the central zone of the body and the lateral nutrient arteries supply that portion near the intervertebral foramen in the adults. The nutrient arteries within body anastomose with each other to form a dense arterial network.The nutrient arteries of the lateral part of the sacrum enter the bone through its ventral, dorsal and medial aspects. Among the dorsal nutrient arteries, there is a main artery that supplies the lateral mass.The arterial supply to the coccyx is scarce. It enters the coccyx mainly through the ventral surface.

Severe acute pancreatitis presents high rate of postoperative complications and results in higher mortality.The main postoperative complications include bleeding,digestive tract fistula,residual infection in the abdominal cavity and retroperitoneum.Along with further deep understanding of the disease and the great changesof treatment,we have new insight for preventing and dealing with the postoperative complications.The damage control surgery combined with minimally invasive surgery concept and individual therapic mode make great effect for the management of postoperative complications.In this review,we focus on the therapies for postoperative complications of severe acute pancreatitis.

Tumor growth and migration are correlated with continuous neovascularization .Slit2-Robo1 signal pathway initially positioned in the nervous system plays an important role in the growth and neuronal axon guidance during migration.However,vascular system resembles the structural features and growth mechanism of neural system .Recent researches have shown that Slit 2-Robo1 signaling pathway plays an important role in vas-cular system,especially in tumor vessel .And Slit2-Robo1 has been shown to play a role in brain metastasis in breast cancer and supporting tumor growth in melanoma .Therefore,the role of Slit2-Robo1 in tumor growth and migration depends on the cancer type .Currently ,researches in this field show controversial results .And the status of Slit2-Robo1 signaling pathway in lung cancer is reviewed in this essay .